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Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix: a case report.

Park HM, Lee SS, Eom DW, Kang GH, Yi SW, Sohn WS - J. Korean Med. Sci. (2009)

Bottom Line: We describe here a patient with this condition and review the clinical and pathological features of these tumors.A 48-yr-old woman complaining of severe dysmenorrhea was referred for investigation of a pelvic mass.Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Gangneung Asan Hospital, University of Ulsan, Gangneung, Korea.

ABSTRACT
Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix is rare in premenopausal woman. We describe here a patient with this condition and review the clinical and pathological features of these tumors. A 48-yr-old woman complaining of severe dysmenorrhea was referred for investigation of a pelvic mass. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Histological examination revealed an endometrioid adenocarcinoma directly adjacent to the endometriosis at the uterine cervix, with a transition observed between endometriosis and endometrioid adenocarcinoma. The patient was diagnosed as having endometrioid adenocarcinoma arising from endometriosis of the uterine cervix and underwent postoperative chemotherapy. Gynecologists and pathologists should be aware of the difficulties associated with a delay in diagnosis of endometrioid adenocarcinoma arising from endometriosis when the tumor presents as a benign looking endometrioma.

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Related in: MedlinePlus

Cut surface of the cervical wall showing well defined hemorrhagic solid lesions (arrow).
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Figure 2: Cut surface of the cervical wall showing well defined hemorrhagic solid lesions (arrow).

Mentions: On gross examination, the cervical wall of the uterus contained a relatively well defined, cystic lesion filled with dark brown fluid, measuring 3×2.2×2.2 cm. The dark brown colored inner surface of the cyst showed multi-focal, papillary growing, solid and granular masses, measuring up to 0.8×0.8×0.5 cm (Fig. 2). Microscopically, these masses were composed of well differentiated endometrioid adenocarcinoma, which was directly adjacent to the epithelium of the endometriotic cyst of the cervical wall. Transitional areas between the glandular epithelium of the endometriosis and the endometrioid adenocarcinoma cells were observed. There was no invasion to the cervical stroma and no connection between the overlying mucosal epithelium of the endo-ectocervix and the epithelium of the endometriosis or the adenocarcinoma. A secretory phase endometrium measured 0.8 cm in thickness. There was no evidence of a primary endometrial or endocervical adenocarcinoma in the endocervix or endometrium (Fig. 3). Multiple foci of endometriosis were present within the posterior wall of the uterus and both ovaries. A serous cystadenoma was also present in the right ovary, measuring 4.0 cm in greatest dimension.


Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix: a case report.

Park HM, Lee SS, Eom DW, Kang GH, Yi SW, Sohn WS - J. Korean Med. Sci. (2009)

Cut surface of the cervical wall showing well defined hemorrhagic solid lesions (arrow).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2719211&req=5

Figure 2: Cut surface of the cervical wall showing well defined hemorrhagic solid lesions (arrow).
Mentions: On gross examination, the cervical wall of the uterus contained a relatively well defined, cystic lesion filled with dark brown fluid, measuring 3×2.2×2.2 cm. The dark brown colored inner surface of the cyst showed multi-focal, papillary growing, solid and granular masses, measuring up to 0.8×0.8×0.5 cm (Fig. 2). Microscopically, these masses were composed of well differentiated endometrioid adenocarcinoma, which was directly adjacent to the epithelium of the endometriotic cyst of the cervical wall. Transitional areas between the glandular epithelium of the endometriosis and the endometrioid adenocarcinoma cells were observed. There was no invasion to the cervical stroma and no connection between the overlying mucosal epithelium of the endo-ectocervix and the epithelium of the endometriosis or the adenocarcinoma. A secretory phase endometrium measured 0.8 cm in thickness. There was no evidence of a primary endometrial or endocervical adenocarcinoma in the endocervix or endometrium (Fig. 3). Multiple foci of endometriosis were present within the posterior wall of the uterus and both ovaries. A serous cystadenoma was also present in the right ovary, measuring 4.0 cm in greatest dimension.

Bottom Line: We describe here a patient with this condition and review the clinical and pathological features of these tumors.A 48-yr-old woman complaining of severe dysmenorrhea was referred for investigation of a pelvic mass.Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Gangneung Asan Hospital, University of Ulsan, Gangneung, Korea.

ABSTRACT
Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix is rare in premenopausal woman. We describe here a patient with this condition and review the clinical and pathological features of these tumors. A 48-yr-old woman complaining of severe dysmenorrhea was referred for investigation of a pelvic mass. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Histological examination revealed an endometrioid adenocarcinoma directly adjacent to the endometriosis at the uterine cervix, with a transition observed between endometriosis and endometrioid adenocarcinoma. The patient was diagnosed as having endometrioid adenocarcinoma arising from endometriosis of the uterine cervix and underwent postoperative chemotherapy. Gynecologists and pathologists should be aware of the difficulties associated with a delay in diagnosis of endometrioid adenocarcinoma arising from endometriosis when the tumor presents as a benign looking endometrioma.

Show MeSH
Related in: MedlinePlus