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Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intravascular ultrasound analysis.

Lee WS, Kim SW, Hong SA, Lee TJ, Park ES, Kim HJ, Lee KJ, Kim TH, Kim CJ, Ryu WS - J. Korean Med. Sci. (2009)

Bottom Line: TkCFAs and TCFAs were defined as advanced FA.Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively).Local reduction of Nogo-B may contribute to plaque formation and/or instability.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. wslee1227@dreamwiz.com

ABSTRACT
The relation of Nogo-B to atherosclerotic plaque progression is not well understood. Thus, the purpose of this study was to assess the expression of Nogo-B in fibroatheromas (FA) of different stages, classified using virtual histology intravascular ultrasound (VH-IVUS) analysis in 19 autopsied cases of non-sudden cardiac death. VH-IVUS imaging analysis was performed 30 mm from the ostium of each coronary artery. VH-IVUS revealed 11 early FAs (34.5+/-8.3 yr), 12 late FAs (42.6+/-16.6 yr), 8 thick-cap FAs (TkCFAs) (46.4+/-11.1 yr), and 6 thin-cap FAs (TCFAs) (51.8+/-6.8 yr). TkCFAs and TCFAs were defined as advanced FA. FA progression advanced with age (P=0.04). VH-IVUS analysis of small, early FAs showed smaller necrotic cores and relatively less calcium compared to more advanced FAs with large necrotic cores (P<0.001). Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively). These findings suggest that FA progression is inversely associated with Nogo-B expression. Local reduction of Nogo-B may contribute to plaque formation and/or instability.

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Related in: MedlinePlus

The correlation between immunohistochemical Nogo-B activity, and plaque composition and CD68/MMP-9 expression. Nogo-B expression carried a significant negative correlation with core necrosis (A), but not with calcification (B). Nogo-B expression had a significant negative correlation with the number of CD68-positive cells (C), but not with MMP-9 expression (D).
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Figure 6: The correlation between immunohistochemical Nogo-B activity, and plaque composition and CD68/MMP-9 expression. Nogo-B expression carried a significant negative correlation with core necrosis (A), but not with calcification (B). Nogo-B expression had a significant negative correlation with the number of CD68-positive cells (C), but not with MMP-9 expression (D).

Mentions: There was a significant inverse relationship between Nogo-B expression and both core necrosis area (r=-0.437, P=0.007) and plaque area (r=-0.398, P=0.015, figure not shown here). However, the relationship between Nogo-B expression and the calcium component or age was not significant (r=-0.212, P=0.209; r=0.038, P=0.821, respectively). In terms of the inflammatory response of atherosclerosis, which not fully established yet, there was a significant inverse correlation between Nogo-B expression and CD68 activity (r=-0.377, P=0.022), while not MMP-9 activity (r=-0.278, P=0.096) (Fig. 6).


Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intravascular ultrasound analysis.

Lee WS, Kim SW, Hong SA, Lee TJ, Park ES, Kim HJ, Lee KJ, Kim TH, Kim CJ, Ryu WS - J. Korean Med. Sci. (2009)

The correlation between immunohistochemical Nogo-B activity, and plaque composition and CD68/MMP-9 expression. Nogo-B expression carried a significant negative correlation with core necrosis (A), but not with calcification (B). Nogo-B expression had a significant negative correlation with the number of CD68-positive cells (C), but not with MMP-9 expression (D).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2719206&req=5

Figure 6: The correlation between immunohistochemical Nogo-B activity, and plaque composition and CD68/MMP-9 expression. Nogo-B expression carried a significant negative correlation with core necrosis (A), but not with calcification (B). Nogo-B expression had a significant negative correlation with the number of CD68-positive cells (C), but not with MMP-9 expression (D).
Mentions: There was a significant inverse relationship between Nogo-B expression and both core necrosis area (r=-0.437, P=0.007) and plaque area (r=-0.398, P=0.015, figure not shown here). However, the relationship between Nogo-B expression and the calcium component or age was not significant (r=-0.212, P=0.209; r=0.038, P=0.821, respectively). In terms of the inflammatory response of atherosclerosis, which not fully established yet, there was a significant inverse correlation between Nogo-B expression and CD68 activity (r=-0.377, P=0.022), while not MMP-9 activity (r=-0.278, P=0.096) (Fig. 6).

Bottom Line: TkCFAs and TCFAs were defined as advanced FA.Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively).Local reduction of Nogo-B may contribute to plaque formation and/or instability.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. wslee1227@dreamwiz.com

ABSTRACT
The relation of Nogo-B to atherosclerotic plaque progression is not well understood. Thus, the purpose of this study was to assess the expression of Nogo-B in fibroatheromas (FA) of different stages, classified using virtual histology intravascular ultrasound (VH-IVUS) analysis in 19 autopsied cases of non-sudden cardiac death. VH-IVUS imaging analysis was performed 30 mm from the ostium of each coronary artery. VH-IVUS revealed 11 early FAs (34.5+/-8.3 yr), 12 late FAs (42.6+/-16.6 yr), 8 thick-cap FAs (TkCFAs) (46.4+/-11.1 yr), and 6 thin-cap FAs (TCFAs) (51.8+/-6.8 yr). TkCFAs and TCFAs were defined as advanced FA. FA progression advanced with age (P=0.04). VH-IVUS analysis of small, early FAs showed smaller necrotic cores and relatively less calcium compared to more advanced FAs with large necrotic cores (P<0.001). Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively). These findings suggest that FA progression is inversely associated with Nogo-B expression. Local reduction of Nogo-B may contribute to plaque formation and/or instability.

Show MeSH
Related in: MedlinePlus