Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intravascular ultrasound analysis.
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TkCFAs and TCFAs were defined as advanced FA.Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively).Local reduction of Nogo-B may contribute to plaque formation and/or instability.
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Affiliation: Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. wslee1227@dreamwiz.com
ABSTRACT
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The relation of Nogo-B to atherosclerotic plaque progression is not well understood. Thus, the purpose of this study was to assess the expression of Nogo-B in fibroatheromas (FA) of different stages, classified using virtual histology intravascular ultrasound (VH-IVUS) analysis in 19 autopsied cases of non-sudden cardiac death. VH-IVUS imaging analysis was performed 30 mm from the ostium of each coronary artery. VH-IVUS revealed 11 early FAs (34.5+/-8.3 yr), 12 late FAs (42.6+/-16.6 yr), 8 thick-cap FAs (TkCFAs) (46.4+/-11.1 yr), and 6 thin-cap FAs (TCFAs) (51.8+/-6.8 yr). TkCFAs and TCFAs were defined as advanced FA. FA progression advanced with age (P=0.04). VH-IVUS analysis of small, early FAs showed smaller necrotic cores and relatively less calcium compared to more advanced FAs with large necrotic cores (P<0.001). Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively). These findings suggest that FA progression is inversely associated with Nogo-B expression. Local reduction of Nogo-B may contribute to plaque formation and/or instability. Related in: MedlinePlus |
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Figure 3: Quantitative graphs of necrotic cores, calcium, CD68-positive macrophages, and MMP-9 activity in various stages of FA. Mentions: H-E staining with VH-IVUS analysis showed that advanced FAs had larger necrotic cores than early FAs (P<0.001) and late FAs (P<0.001) did (Fig. 2A, B, F, G; Fig. 3A). |
View Article: PubMed Central - PubMed
Affiliation: Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. wslee1227@dreamwiz.com