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Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intravascular ultrasound analysis.

Lee WS, Kim SW, Hong SA, Lee TJ, Park ES, Kim HJ, Lee KJ, Kim TH, Kim CJ, Ryu WS - J. Korean Med. Sci. (2009)

Bottom Line: TkCFAs and TCFAs were defined as advanced FA.Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively).Local reduction of Nogo-B may contribute to plaque formation and/or instability.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. wslee1227@dreamwiz.com

ABSTRACT
The relation of Nogo-B to atherosclerotic plaque progression is not well understood. Thus, the purpose of this study was to assess the expression of Nogo-B in fibroatheromas (FA) of different stages, classified using virtual histology intravascular ultrasound (VH-IVUS) analysis in 19 autopsied cases of non-sudden cardiac death. VH-IVUS imaging analysis was performed 30 mm from the ostium of each coronary artery. VH-IVUS revealed 11 early FAs (34.5+/-8.3 yr), 12 late FAs (42.6+/-16.6 yr), 8 thick-cap FAs (TkCFAs) (46.4+/-11.1 yr), and 6 thin-cap FAs (TCFAs) (51.8+/-6.8 yr). TkCFAs and TCFAs were defined as advanced FA. FA progression advanced with age (P=0.04). VH-IVUS analysis of small, early FAs showed smaller necrotic cores and relatively less calcium compared to more advanced FAs with large necrotic cores (P<0.001). Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively). These findings suggest that FA progression is inversely associated with Nogo-B expression. Local reduction of Nogo-B may contribute to plaque formation and/or instability.

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Related in: MedlinePlus

Classification of fibroatheromas by virtual histology intravascular ultrasound. Early fibroatheromas (A) had less extensively necrotic cores (red color) and greater fibrous (green color) composition, while thick-cap fibroatheromas (C) and thin-cap fibroatheromas (D) had larger necrotic cores and more extensive calcium (white color) deposition.F, fibrous; FF, fibrofatty; NC, necrotic core; DC, dense calcium.
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Figure 1: Classification of fibroatheromas by virtual histology intravascular ultrasound. Early fibroatheromas (A) had less extensively necrotic cores (red color) and greater fibrous (green color) composition, while thick-cap fibroatheromas (C) and thin-cap fibroatheromas (D) had larger necrotic cores and more extensive calcium (white color) deposition.F, fibrous; FF, fibrofatty; NC, necrotic core; DC, dense calcium.

Mentions: Coronary FAs were classified into 4 groups: early FA (n=11), late FA (n=12), TkCFA (n=8), and TCFA (n=6), by VH-IVUS (Fig. 1). There were significant differences in the mean age of FA progression (early FA 34.5±8.3 yr, late FA 42.6±16.6 yr, TkCFA 46.4±11.1 yr, and TCFA 51.8±6.8 yr, respectively, P=0.04). However, the relationship between NC and the age was not significant (r=0.087, P=0.609).


Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intravascular ultrasound analysis.

Lee WS, Kim SW, Hong SA, Lee TJ, Park ES, Kim HJ, Lee KJ, Kim TH, Kim CJ, Ryu WS - J. Korean Med. Sci. (2009)

Classification of fibroatheromas by virtual histology intravascular ultrasound. Early fibroatheromas (A) had less extensively necrotic cores (red color) and greater fibrous (green color) composition, while thick-cap fibroatheromas (C) and thin-cap fibroatheromas (D) had larger necrotic cores and more extensive calcium (white color) deposition.F, fibrous; FF, fibrofatty; NC, necrotic core; DC, dense calcium.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2719206&req=5

Figure 1: Classification of fibroatheromas by virtual histology intravascular ultrasound. Early fibroatheromas (A) had less extensively necrotic cores (red color) and greater fibrous (green color) composition, while thick-cap fibroatheromas (C) and thin-cap fibroatheromas (D) had larger necrotic cores and more extensive calcium (white color) deposition.F, fibrous; FF, fibrofatty; NC, necrotic core; DC, dense calcium.
Mentions: Coronary FAs were classified into 4 groups: early FA (n=11), late FA (n=12), TkCFA (n=8), and TCFA (n=6), by VH-IVUS (Fig. 1). There were significant differences in the mean age of FA progression (early FA 34.5±8.3 yr, late FA 42.6±16.6 yr, TkCFA 46.4±11.1 yr, and TCFA 51.8±6.8 yr, respectively, P=0.04). However, the relationship between NC and the age was not significant (r=0.087, P=0.609).

Bottom Line: TkCFAs and TCFAs were defined as advanced FA.Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively).Local reduction of Nogo-B may contribute to plaque formation and/or instability.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. wslee1227@dreamwiz.com

ABSTRACT
The relation of Nogo-B to atherosclerotic plaque progression is not well understood. Thus, the purpose of this study was to assess the expression of Nogo-B in fibroatheromas (FA) of different stages, classified using virtual histology intravascular ultrasound (VH-IVUS) analysis in 19 autopsied cases of non-sudden cardiac death. VH-IVUS imaging analysis was performed 30 mm from the ostium of each coronary artery. VH-IVUS revealed 11 early FAs (34.5+/-8.3 yr), 12 late FAs (42.6+/-16.6 yr), 8 thick-cap FAs (TkCFAs) (46.4+/-11.1 yr), and 6 thin-cap FAs (TCFAs) (51.8+/-6.8 yr). TkCFAs and TCFAs were defined as advanced FA. FA progression advanced with age (P=0.04). VH-IVUS analysis of small, early FAs showed smaller necrotic cores and relatively less calcium compared to more advanced FAs with large necrotic cores (P<0.001). Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively). These findings suggest that FA progression is inversely associated with Nogo-B expression. Local reduction of Nogo-B may contribute to plaque formation and/or instability.

Show MeSH
Related in: MedlinePlus