Limits...
Sinus histiocytosis with massive lymphadenopathy: a case report with pleural effusion and cervical lymphadenopathy.

Ju J, Kwon YS, Jo KJ, Chae DR, Lim JH, Ban HJ, Chi SY, Oh IJ, Kim KS, Kim YI, Kim YC, Lim SC - J. Korean Med. Sci. (2009)

Bottom Line: A 26-yr-old man presented with painless palpable lymph node in cervical area.Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum.The cells stained positive with CD68 and S-100.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.

ABSTRACT
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML.

Show MeSH

Related in: MedlinePlus

Immunohistochemical staining for CD68 and S-100 protein. Histiocytes show positive immunoreactivity with brown color for CD 68 (A, ×400) and S-100 (B, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2719199&req=5

Figure 3: Immunohistochemical staining for CD68 and S-100 protein. Histiocytes show positive immunoreactivity with brown color for CD 68 (A, ×400) and S-100 (B, ×400).

Mentions: A 26-yr-old man presented with a firm, nontender palpable lymph node in his left cervical area. The patient had no specific past medical history. On admission his blood pressure was 120/80 mm Hg, pulse rate 80/min, respiratory rate 24/min, and body temperature 36.5℃. Routine laboratory investigations showed a normal complete blood count, serum chemical tests, and erythrocyte sedimentation rate (ESR). Serologic tests for cytomegalovirus, human immunodeficiency virus (HIV) and polymerase chain reaction (PCR) analysis of mycobacteria yield negative results. Serum immunoglobulin (Ig) levels were as follows: IgG, 1,680 mg/dL (normal 700-1,700 mg/dL); IgA, 117 mg/dL (normal 70-400 mg/dL); IgM, 129 mg/dL (normal 40-230 mg/dL); and IgE, 33.8 IU/mL (normal 0-100 IU/mL). Computed tomography of the chest showed mediastinal lymph nodes with calcification and pleural effusion (Fig. 1). Diagnostic thoracentesis was not performed because of scanty pleural effusion. Excisional biopsy of the cervical lymph node revealed dilated sinuses filled with histiocytes with abundant pale eosinophilic cytoplasm (Fig. 2). The histiocytes were positive immunoreactivities for CD68 and S-100 protein (Fig. 3). These findings were diagnostic of SHML. The patient had received prednisolone therapy (30 mg per day, PO). On follow-up the patient was well without symptoms and signs.


Sinus histiocytosis with massive lymphadenopathy: a case report with pleural effusion and cervical lymphadenopathy.

Ju J, Kwon YS, Jo KJ, Chae DR, Lim JH, Ban HJ, Chi SY, Oh IJ, Kim KS, Kim YI, Kim YC, Lim SC - J. Korean Med. Sci. (2009)

Immunohistochemical staining for CD68 and S-100 protein. Histiocytes show positive immunoreactivity with brown color for CD 68 (A, ×400) and S-100 (B, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2719199&req=5

Figure 3: Immunohistochemical staining for CD68 and S-100 protein. Histiocytes show positive immunoreactivity with brown color for CD 68 (A, ×400) and S-100 (B, ×400).
Mentions: A 26-yr-old man presented with a firm, nontender palpable lymph node in his left cervical area. The patient had no specific past medical history. On admission his blood pressure was 120/80 mm Hg, pulse rate 80/min, respiratory rate 24/min, and body temperature 36.5℃. Routine laboratory investigations showed a normal complete blood count, serum chemical tests, and erythrocyte sedimentation rate (ESR). Serologic tests for cytomegalovirus, human immunodeficiency virus (HIV) and polymerase chain reaction (PCR) analysis of mycobacteria yield negative results. Serum immunoglobulin (Ig) levels were as follows: IgG, 1,680 mg/dL (normal 700-1,700 mg/dL); IgA, 117 mg/dL (normal 70-400 mg/dL); IgM, 129 mg/dL (normal 40-230 mg/dL); and IgE, 33.8 IU/mL (normal 0-100 IU/mL). Computed tomography of the chest showed mediastinal lymph nodes with calcification and pleural effusion (Fig. 1). Diagnostic thoracentesis was not performed because of scanty pleural effusion. Excisional biopsy of the cervical lymph node revealed dilated sinuses filled with histiocytes with abundant pale eosinophilic cytoplasm (Fig. 2). The histiocytes were positive immunoreactivities for CD68 and S-100 protein (Fig. 3). These findings were diagnostic of SHML. The patient had received prednisolone therapy (30 mg per day, PO). On follow-up the patient was well without symptoms and signs.

Bottom Line: A 26-yr-old man presented with painless palpable lymph node in cervical area.Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum.The cells stained positive with CD68 and S-100.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.

ABSTRACT
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML.

Show MeSH
Related in: MedlinePlus