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Is the blood B-cell subset profile diagnostic for Sjogren syndrome?

Binard A, Le Pottier L, Devauchelle-Pensec V, Saraux A, Youinou P, Pers JO - Ann. Rheum. Dis. (2008)

Bottom Line: The percentage of Bm2 and Bm2' cells was increased in the patients with pSS compared with 54 patients with rheumatoid arthritis (RA) and 18 with systemic lupus erythematosus (SLE) (p<0.001 for the two comparisons).In contrast, those of early Bm5 (eBm5) and Bm5 were decreased in patients with pSS, compared with patients with RA and with SLE (p<0.001 for the two comparisons).Given its presentation as a signature for pSS, relative to RA and SLE, such a distribution of B-cell subsets might provide a useful diagnostic tool.

View Article: PubMed Central - PubMed

Affiliation: EA Immunologie et Pathologie, Université Européenne de Bretagne, et Université de Bretagne Occidentale, Brest, et Centre Hospitalier Universitaire de Brest, Brest F29609, France.

ABSTRACT

Objective: To evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome.

Methods: The distribution of mature blood B cells from Bm1 through Bm5 was determined in 161 patients, of whom 25 fulfilled the American-European Consensus Group criteria for primary SS (pSS), and 136 served as disease controls.

Results: The percentage of Bm2 and Bm2' cells was increased in the patients with pSS compared with 54 patients with rheumatoid arthritis (RA) and 18 with systemic lupus erythematosus (SLE) (p<0.001 for the two comparisons). In contrast, those of early Bm5 (eBm5) and Bm5 were decreased in patients with pSS, compared with patients with RA and with SLE (p<0.001 for the two comparisons). The receiver operating characteristic curves allowed for an optimising cut-off value of Bm2+Bm2' cells at 71.1% for 88.0% sensitivity and 83.1% specificity, that of eBm5+Bm5 cells at < or =13.5% for 84.0% sensitivity and 83.1% specificity, and, consequently, that of Bm2+Bm2'/eBm5+Bm5 at > or =5 for 88.0% sensitivity and 84.6% specificity.

Conclusion: Given its presentation as a signature for pSS, relative to RA and SLE, such a distribution of B-cell subsets might provide a useful diagnostic tool.

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Receiver-operating characteristic curves of B-cell subsets for the diagnosis of primary Sjögren syndrome.
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ARD-68-09-1447-f02: Receiver-operating characteristic curves of B-cell subsets for the diagnosis of primary Sjögren syndrome.

Mentions: Relationships between AECG-based diagnosis of pSS and B-cell subsets (taken alone or in combination) were evaluated in 25 patients with pSS and 136 disease controls. The best combinations for the diagnosis of pSS (fig 2A, table 3) were Bm2+Bm2′ ⩾71.1% (sensitivity 88.0% and specificity 83.1%), eBm5+Bm5 ⩽13.5% (sensitivity 84.0% and specificity 83.1%), and, even better, the ratio of Bm2+Bm2′ to eBm5+Bm5 ⩾5 (sensitivity 88.0% and specificity 84.6%). Lower associations were seen (fig 2B) with eBm5 ⩽6.7% alone (sensitivity 80.0% and specificity 72.8%), Bm5 ⩽7.6% alone (sensitivity 84.0% and specificity 80.1%), and Bm2 ⩾59.9% alone (sensitivity 80.0% and specificity 75.7%). Parenthetically, the relative percentages of Bm1 and Bm2′ were weakly associated with pSS.


Is the blood B-cell subset profile diagnostic for Sjogren syndrome?

Binard A, Le Pottier L, Devauchelle-Pensec V, Saraux A, Youinou P, Pers JO - Ann. Rheum. Dis. (2008)

Receiver-operating characteristic curves of B-cell subsets for the diagnosis of primary Sjögren syndrome.
© Copyright Policy - openaccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2719083&req=5

ARD-68-09-1447-f02: Receiver-operating characteristic curves of B-cell subsets for the diagnosis of primary Sjögren syndrome.
Mentions: Relationships between AECG-based diagnosis of pSS and B-cell subsets (taken alone or in combination) were evaluated in 25 patients with pSS and 136 disease controls. The best combinations for the diagnosis of pSS (fig 2A, table 3) were Bm2+Bm2′ ⩾71.1% (sensitivity 88.0% and specificity 83.1%), eBm5+Bm5 ⩽13.5% (sensitivity 84.0% and specificity 83.1%), and, even better, the ratio of Bm2+Bm2′ to eBm5+Bm5 ⩾5 (sensitivity 88.0% and specificity 84.6%). Lower associations were seen (fig 2B) with eBm5 ⩽6.7% alone (sensitivity 80.0% and specificity 72.8%), Bm5 ⩽7.6% alone (sensitivity 84.0% and specificity 80.1%), and Bm2 ⩾59.9% alone (sensitivity 80.0% and specificity 75.7%). Parenthetically, the relative percentages of Bm1 and Bm2′ were weakly associated with pSS.

Bottom Line: The percentage of Bm2 and Bm2' cells was increased in the patients with pSS compared with 54 patients with rheumatoid arthritis (RA) and 18 with systemic lupus erythematosus (SLE) (p<0.001 for the two comparisons).In contrast, those of early Bm5 (eBm5) and Bm5 were decreased in patients with pSS, compared with patients with RA and with SLE (p<0.001 for the two comparisons).Given its presentation as a signature for pSS, relative to RA and SLE, such a distribution of B-cell subsets might provide a useful diagnostic tool.

View Article: PubMed Central - PubMed

Affiliation: EA Immunologie et Pathologie, Université Européenne de Bretagne, et Université de Bretagne Occidentale, Brest, et Centre Hospitalier Universitaire de Brest, Brest F29609, France.

ABSTRACT

Objective: To evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome.

Methods: The distribution of mature blood B cells from Bm1 through Bm5 was determined in 161 patients, of whom 25 fulfilled the American-European Consensus Group criteria for primary SS (pSS), and 136 served as disease controls.

Results: The percentage of Bm2 and Bm2' cells was increased in the patients with pSS compared with 54 patients with rheumatoid arthritis (RA) and 18 with systemic lupus erythematosus (SLE) (p<0.001 for the two comparisons). In contrast, those of early Bm5 (eBm5) and Bm5 were decreased in patients with pSS, compared with patients with RA and with SLE (p<0.001 for the two comparisons). The receiver operating characteristic curves allowed for an optimising cut-off value of Bm2+Bm2' cells at 71.1% for 88.0% sensitivity and 83.1% specificity, that of eBm5+Bm5 cells at < or =13.5% for 84.0% sensitivity and 83.1% specificity, and, consequently, that of Bm2+Bm2'/eBm5+Bm5 at > or =5 for 88.0% sensitivity and 84.6% specificity.

Conclusion: Given its presentation as a signature for pSS, relative to RA and SLE, such a distribution of B-cell subsets might provide a useful diagnostic tool.

Show MeSH
Related in: MedlinePlus