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Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors.

Rozie S, de Weert TT, de Monyé C, Homburg PJ, Tanghe HL, Dippel DW, van der Lugt A - Eur Radiol (2009)

Bottom Line: Age and smoking were independently related to PV.Patients with hypercholesterolemia had significantly less lipid and more calcium in their plaques than patients without hypercholesterolemia.Luminal stenosis of the carotid artery partly reflects the amount of atherosclerotic carotid disease.

View Article: PubMed Central - PubMed

Affiliation: Departments of Radiology, Erasmus MC, University Medical Center Rotterdam, s-Gravendijkwal 230, Rotterdam 3015 CE, The Netherlands.

ABSTRACT
The purpose of this study was to examine the volume and the composition of atherosclerotic plaque in symptomatic carotid arteries and to investigate the relationship between these plaque features and the severity of stenosis and the presence of cardiovascular risk factors. One hundred patients with cerebrovascular symptoms underwent CT angiography. We measured plaque volume (PV) and the relative contribution of plaque components (calcifications, fibrous tissue, and lipid) in the symptomatic artery. The contribution of different components was measured as the number of voxels within defined ranges of HU values (calcification >130 HU, fibrous tissue 60-130 HU, lipid core <60 HU). Fifty-seven patients had atherosclerotic plaque in the symptomatic carotid artery. The severity of stenosis and PV were moderately correlated. Age and smoking were independently related to PV. Patients with hypercholesterolemia had significantly less lipid and more calcium in their plaques than patients without hypercholesterolemia. Other cardiovascular risk factors were not significantly related to PV or plaque composition. Luminal stenosis of the carotid artery partly reflects the amount of atherosclerotic carotid disease. Plaque volume and plaque composition are associated with cardiovascular risk factors.

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Related in: MedlinePlus

Semi-automatic assessment of plaque component areas in MDCT images. Axial MDCT image of an atherosclerotic carotid plaque; the region of interest is drawn on the outer vessel wall (a). Ranges of Hounsfield units (HU) represent three different plaque components: yellow lipid core (<60 HU), red fibrous tissue (60–130 HU), and white calcification (>130 HU) (b)
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Fig1: Semi-automatic assessment of plaque component areas in MDCT images. Axial MDCT image of an atherosclerotic carotid plaque; the region of interest is drawn on the outer vessel wall (a). Ranges of Hounsfield units (HU) represent three different plaque components: yellow lipid core (<60 HU), red fibrous tissue (60–130 HU), and white calcification (>130 HU) (b)

Mentions: We measured plaque and plaque-component volumes with a polymeasure plug-in [9] for the freely available software package ImageJ (Rasband, National Institute of Mental Health, Bethesda, MD, USA) (Fig. 1).Fig. 1


Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors.

Rozie S, de Weert TT, de Monyé C, Homburg PJ, Tanghe HL, Dippel DW, van der Lugt A - Eur Radiol (2009)

Semi-automatic assessment of plaque component areas in MDCT images. Axial MDCT image of an atherosclerotic carotid plaque; the region of interest is drawn on the outer vessel wall (a). Ranges of Hounsfield units (HU) represent three different plaque components: yellow lipid core (<60 HU), red fibrous tissue (60–130 HU), and white calcification (>130 HU) (b)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2719076&req=5

Fig1: Semi-automatic assessment of plaque component areas in MDCT images. Axial MDCT image of an atherosclerotic carotid plaque; the region of interest is drawn on the outer vessel wall (a). Ranges of Hounsfield units (HU) represent three different plaque components: yellow lipid core (<60 HU), red fibrous tissue (60–130 HU), and white calcification (>130 HU) (b)
Mentions: We measured plaque and plaque-component volumes with a polymeasure plug-in [9] for the freely available software package ImageJ (Rasband, National Institute of Mental Health, Bethesda, MD, USA) (Fig. 1).Fig. 1

Bottom Line: Age and smoking were independently related to PV.Patients with hypercholesterolemia had significantly less lipid and more calcium in their plaques than patients without hypercholesterolemia.Luminal stenosis of the carotid artery partly reflects the amount of atherosclerotic carotid disease.

View Article: PubMed Central - PubMed

Affiliation: Departments of Radiology, Erasmus MC, University Medical Center Rotterdam, s-Gravendijkwal 230, Rotterdam 3015 CE, The Netherlands.

ABSTRACT
The purpose of this study was to examine the volume and the composition of atherosclerotic plaque in symptomatic carotid arteries and to investigate the relationship between these plaque features and the severity of stenosis and the presence of cardiovascular risk factors. One hundred patients with cerebrovascular symptoms underwent CT angiography. We measured plaque volume (PV) and the relative contribution of plaque components (calcifications, fibrous tissue, and lipid) in the symptomatic artery. The contribution of different components was measured as the number of voxels within defined ranges of HU values (calcification >130 HU, fibrous tissue 60-130 HU, lipid core <60 HU). Fifty-seven patients had atherosclerotic plaque in the symptomatic carotid artery. The severity of stenosis and PV were moderately correlated. Age and smoking were independently related to PV. Patients with hypercholesterolemia had significantly less lipid and more calcium in their plaques than patients without hypercholesterolemia. Other cardiovascular risk factors were not significantly related to PV or plaque composition. Luminal stenosis of the carotid artery partly reflects the amount of atherosclerotic carotid disease. Plaque volume and plaque composition are associated with cardiovascular risk factors.

Show MeSH
Related in: MedlinePlus