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Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases.

Gabriel SE, Michaud K - Arthritis Res. Ther. (2009)

Bottom Line: Epidemiology is the study of the distribution and determinants of disease in human populations.These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions--a reflection of the impact of genetic and environmental factors.Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Health Sciences Research, Mayo Foundation, Rochester, MN 55905, USA. gabriel.sherine@mayo.edu

ABSTRACT
Epidemiology is the study of the distribution and determinants of disease in human populations. Over the past decade there has been considerable progress in our understanding of the fundamental descriptive epidemiology (levels of disease frequency: incidence and prevalence, comorbidity, mortality, trends over time, geographic distributions, and clinical characteristics) of the rheumatic diseases. This progress is reviewed for the following major rheumatic diseases: rheumatoid arthritis (RA), juvenile rheumatoid arthritis, psoriatic arthritis, osteoarthritis, systemic lupus erythematosus, giant cell arteritis, polymyalgia rheumatica, gout, Sjögren's syndrome, and ankylosing spondylitis. These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions--a reflection of the impact of genetic and environmental factors. The past decade has also brought new insights regarding the comorbidity associated with rheumatic diseases. Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population. Taken together, these findings underscore the complexity of the rheumatic diseases and highlight the key role of epidemiological research in understanding these intriguing conditions.

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Related in: MedlinePlus

Incidence of congestive heart failure: RA versus non-RA. Shown is a comparison of the cumulative incidence of congestive heart failure in the rheumatoid arthritis (RA) and non-RA cohort, according to years since index date, adjusting for the competing risk for death. Reproduced from [117] with permission.
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Figure 8: Incidence of congestive heart failure: RA versus non-RA. Shown is a comparison of the cumulative incidence of congestive heart failure in the rheumatoid arthritis (RA) and non-RA cohort, according to years since index date, adjusting for the competing risk for death. Reproduced from [117] with permission.

Mentions: An emerging body of literature now indicates that persons with RA are also at increased risk for heart failure. The cumulative incidence of heart failure defined according to Framingham Heart Study criteria [116] after incident RA has been shown to be statistically significantly higher in persons with RA than in those without the disease in a population-based setting [117] (Figure 8).


Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases.

Gabriel SE, Michaud K - Arthritis Res. Ther. (2009)

Incidence of congestive heart failure: RA versus non-RA. Shown is a comparison of the cumulative incidence of congestive heart failure in the rheumatoid arthritis (RA) and non-RA cohort, according to years since index date, adjusting for the competing risk for death. Reproduced from [117] with permission.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2714099&req=5

Figure 8: Incidence of congestive heart failure: RA versus non-RA. Shown is a comparison of the cumulative incidence of congestive heart failure in the rheumatoid arthritis (RA) and non-RA cohort, according to years since index date, adjusting for the competing risk for death. Reproduced from [117] with permission.
Mentions: An emerging body of literature now indicates that persons with RA are also at increased risk for heart failure. The cumulative incidence of heart failure defined according to Framingham Heart Study criteria [116] after incident RA has been shown to be statistically significantly higher in persons with RA than in those without the disease in a population-based setting [117] (Figure 8).

Bottom Line: Epidemiology is the study of the distribution and determinants of disease in human populations.These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions--a reflection of the impact of genetic and environmental factors.Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Health Sciences Research, Mayo Foundation, Rochester, MN 55905, USA. gabriel.sherine@mayo.edu

ABSTRACT
Epidemiology is the study of the distribution and determinants of disease in human populations. Over the past decade there has been considerable progress in our understanding of the fundamental descriptive epidemiology (levels of disease frequency: incidence and prevalence, comorbidity, mortality, trends over time, geographic distributions, and clinical characteristics) of the rheumatic diseases. This progress is reviewed for the following major rheumatic diseases: rheumatoid arthritis (RA), juvenile rheumatoid arthritis, psoriatic arthritis, osteoarthritis, systemic lupus erythematosus, giant cell arteritis, polymyalgia rheumatica, gout, Sjögren's syndrome, and ankylosing spondylitis. These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions--a reflection of the impact of genetic and environmental factors. The past decade has also brought new insights regarding the comorbidity associated with rheumatic diseases. Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population. Taken together, these findings underscore the complexity of the rheumatic diseases and highlight the key role of epidemiological research in understanding these intriguing conditions.

Show MeSH
Related in: MedlinePlus