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Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases.

Gabriel SE, Michaud K - Arthritis Res. Ther. (2009)

Bottom Line: Epidemiology is the study of the distribution and determinants of disease in human populations.These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions--a reflection of the impact of genetic and environmental factors.Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Health Sciences Research, Mayo Foundation, Rochester, MN 55905, USA. gabriel.sherine@mayo.edu

ABSTRACT
Epidemiology is the study of the distribution and determinants of disease in human populations. Over the past decade there has been considerable progress in our understanding of the fundamental descriptive epidemiology (levels of disease frequency: incidence and prevalence, comorbidity, mortality, trends over time, geographic distributions, and clinical characteristics) of the rheumatic diseases. This progress is reviewed for the following major rheumatic diseases: rheumatoid arthritis (RA), juvenile rheumatoid arthritis, psoriatic arthritis, osteoarthritis, systemic lupus erythematosus, giant cell arteritis, polymyalgia rheumatica, gout, Sjögren's syndrome, and ankylosing spondylitis. These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions--a reflection of the impact of genetic and environmental factors. The past decade has also brought new insights regarding the comorbidity associated with rheumatic diseases. Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population. Taken together, these findings underscore the complexity of the rheumatic diseases and highlight the key role of epidemiological research in understanding these intriguing conditions.

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Related in: MedlinePlus

Annual incidence of rheumatoid arthritis in Rochester, Minnesota. Shown is the annual incidence rate per 100,000 population by sex: 1955 to 1995. Each rate was calculated as a 3-year centered moving average. Reproduced from [9] with permission.
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Figure 1: Annual incidence of rheumatoid arthritis in Rochester, Minnesota. Shown is the annual incidence rate per 100,000 population by sex: 1955 to 1995. Each rate was calculated as a 3-year centered moving average. Reproduced from [9] with permission.

Mentions: Data from Rochester (Minnesota, USA) demonstrate that although the incidence rate fell progressively over the four decades of study – from 61.2/100,000 in 1955 to 1964, to 32.7/100,000 in 1985 to 1994 – there were indications of cyclical trends over time (Figure 1) [9]. Moreover, data from the past decade suggest that RA incidence (at least in women) appears to be rising after four decades of decline [10].


Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases.

Gabriel SE, Michaud K - Arthritis Res. Ther. (2009)

Annual incidence of rheumatoid arthritis in Rochester, Minnesota. Shown is the annual incidence rate per 100,000 population by sex: 1955 to 1995. Each rate was calculated as a 3-year centered moving average. Reproduced from [9] with permission.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2714099&req=5

Figure 1: Annual incidence of rheumatoid arthritis in Rochester, Minnesota. Shown is the annual incidence rate per 100,000 population by sex: 1955 to 1995. Each rate was calculated as a 3-year centered moving average. Reproduced from [9] with permission.
Mentions: Data from Rochester (Minnesota, USA) demonstrate that although the incidence rate fell progressively over the four decades of study – from 61.2/100,000 in 1955 to 1964, to 32.7/100,000 in 1985 to 1994 – there were indications of cyclical trends over time (Figure 1) [9]. Moreover, data from the past decade suggest that RA incidence (at least in women) appears to be rising after four decades of decline [10].

Bottom Line: Epidemiology is the study of the distribution and determinants of disease in human populations.These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions--a reflection of the impact of genetic and environmental factors.Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Health Sciences Research, Mayo Foundation, Rochester, MN 55905, USA. gabriel.sherine@mayo.edu

ABSTRACT
Epidemiology is the study of the distribution and determinants of disease in human populations. Over the past decade there has been considerable progress in our understanding of the fundamental descriptive epidemiology (levels of disease frequency: incidence and prevalence, comorbidity, mortality, trends over time, geographic distributions, and clinical characteristics) of the rheumatic diseases. This progress is reviewed for the following major rheumatic diseases: rheumatoid arthritis (RA), juvenile rheumatoid arthritis, psoriatic arthritis, osteoarthritis, systemic lupus erythematosus, giant cell arteritis, polymyalgia rheumatica, gout, Sjögren's syndrome, and ankylosing spondylitis. These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions--a reflection of the impact of genetic and environmental factors. The past decade has also brought new insights regarding the comorbidity associated with rheumatic diseases. Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population. Taken together, these findings underscore the complexity of the rheumatic diseases and highlight the key role of epidemiological research in understanding these intriguing conditions.

Show MeSH
Related in: MedlinePlus