Limits...
Sub-typing of renal cell tumours; contribution of ancillary techniques.

Pradhan D, Kakkar N, Bal A, Singh SK, Joshi K - Diagn Pathol (2009)

Bottom Line: Eight cases were of sarcomatoid renal cell carcinoma.Relative incidence of sub-types of RCCs was compared with other series.However, in India, RCCs afflict the patients two decades earlier.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Histopathology, Post Graduate Institute of Medical Sciences & Research, Chandigarh, India. dppgi4u@gmail.com

ABSTRACT

Background: Adult renal epithelial neoplasms are a heterogeneous group with varying prognosis and outcome requiring sub-classification.

Methods: Cases of renal cell carcinoma (RCC) in a 10 years period were analyzed with regard to the clinical features and histology. Sections were reviewed by four pathologists and the discordant cases were resolved with the help of Hale's colloidal iron stain, vimentin, CK 7, and vinculin immunostains and electron microscopy.

Results: Amongst the total of 278 cases, clear cell renal cell carcinoma was the commonest tumor with 74.8% cases, followed by papillary RCC 12.2%, chromophobe RCC 7.9%, oncocytoma 1.8%, and one case of collecting duct RCC. Eight cases were of sarcomatoid renal cell carcinoma. In 28/278 cases, diagnoses varied amongst the four pathologists and the discordance was resolved by Hale's colloidal iron stain, CK7 immunostain and electron microscopy. Vimentin and vinculin did not contribute much in differentiating subtypes of renal cell carcinomas. Relative incidence of sub-types of RCCs was compared with other series.

Conclusion: To accurately subclassify renal cell carcinomas, simple ancillary techniques would possibly resolve all difficult cases. The relative incidence of sub-types of renal cell carcinoma is relatively consistent the world over. However, in India, RCCs afflict the patients two decades earlier.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical staining using CK7 antibody showing strong and diffuse membranous positivity in chromophobe renal cell carcinoma(A) and collecting duct carcinoma(B) (CK7, ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2714064&req=5

Figure 3: Immunohistochemical staining using CK7 antibody showing strong and diffuse membranous positivity in chromophobe renal cell carcinoma(A) and collecting duct carcinoma(B) (CK7, ×200).

Mentions: CK 7 (Fig. 2 and 3): was positive in 90%(9/10) cases of papillary renal cell carcinoma (p < 0.001) and was more frequently observed in type 1 (100%) than type 2 (75%) tumours. All the cases of chromophobe renal cell carcinoma (10/10) and collecting duct carcinoma (1/1) were positive. It was negative in all 20 cases of clear cell renal cell carcinoma and 5 cases of renal oncocytoma.


Sub-typing of renal cell tumours; contribution of ancillary techniques.

Pradhan D, Kakkar N, Bal A, Singh SK, Joshi K - Diagn Pathol (2009)

Immunohistochemical staining using CK7 antibody showing strong and diffuse membranous positivity in chromophobe renal cell carcinoma(A) and collecting duct carcinoma(B) (CK7, ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2714064&req=5

Figure 3: Immunohistochemical staining using CK7 antibody showing strong and diffuse membranous positivity in chromophobe renal cell carcinoma(A) and collecting duct carcinoma(B) (CK7, ×200).
Mentions: CK 7 (Fig. 2 and 3): was positive in 90%(9/10) cases of papillary renal cell carcinoma (p < 0.001) and was more frequently observed in type 1 (100%) than type 2 (75%) tumours. All the cases of chromophobe renal cell carcinoma (10/10) and collecting duct carcinoma (1/1) were positive. It was negative in all 20 cases of clear cell renal cell carcinoma and 5 cases of renal oncocytoma.

Bottom Line: Eight cases were of sarcomatoid renal cell carcinoma.Relative incidence of sub-types of RCCs was compared with other series.However, in India, RCCs afflict the patients two decades earlier.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Histopathology, Post Graduate Institute of Medical Sciences & Research, Chandigarh, India. dppgi4u@gmail.com

ABSTRACT

Background: Adult renal epithelial neoplasms are a heterogeneous group with varying prognosis and outcome requiring sub-classification.

Methods: Cases of renal cell carcinoma (RCC) in a 10 years period were analyzed with regard to the clinical features and histology. Sections were reviewed by four pathologists and the discordant cases were resolved with the help of Hale's colloidal iron stain, vimentin, CK 7, and vinculin immunostains and electron microscopy.

Results: Amongst the total of 278 cases, clear cell renal cell carcinoma was the commonest tumor with 74.8% cases, followed by papillary RCC 12.2%, chromophobe RCC 7.9%, oncocytoma 1.8%, and one case of collecting duct RCC. Eight cases were of sarcomatoid renal cell carcinoma. In 28/278 cases, diagnoses varied amongst the four pathologists and the discordance was resolved by Hale's colloidal iron stain, CK7 immunostain and electron microscopy. Vimentin and vinculin did not contribute much in differentiating subtypes of renal cell carcinomas. Relative incidence of sub-types of RCCs was compared with other series.

Conclusion: To accurately subclassify renal cell carcinomas, simple ancillary techniques would possibly resolve all difficult cases. The relative incidence of sub-types of renal cell carcinoma is relatively consistent the world over. However, in India, RCCs afflict the patients two decades earlier.

No MeSH data available.


Related in: MedlinePlus