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Perfusion MR imaging: clinical utility for the differential diagnosis of various brain tumors.

Cho SK, Na DG, Ryoo JW, Roh HG, Moon CH, Byun HS, Kim JH - Korean J Radiol (2002 Jul-Sep)

Bottom Line: The highest rCBV ratios were seen in hemangioblastomas, followed by high-grade gliomas, metastases, low-grade gliomas, and lymphomas.At visual assessment, rCBV was high in 17 (81%) of 21 high-grade gliomas and in 4 (50%) of 8 low-grade gliomas.Hemangioblastomas showed the highest rCBV and lymphomas the lowest.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Objective: To determine the utility of perfusion MR imaging in the differential diagnosis of brain tumors.

Materials and methods: Fifty-seven patients with pathologically proven brain tumors (21 high-grade gliomas, 8 low-grade gliomas, 8 lymphomas, 6 hemangioblastomas, 7 metastases, and 7 various other tumors) were included in this study. Relative cerebral blood volume (rCBV) and time-to-peak (TTP) ratios were quantitatively analyzed and the rCBV grade of each tumor was also visually assessed on an rCBV map.

Results: The highest rCBV ratios were seen in hemangioblastomas, followed by high-grade gliomas, metastases, low-grade gliomas, and lymphomas. There was no significant difference in TTP ratios between each tumor group (p<0.05). At visual assessment, rCBV was high in 17 (81%) of 21 high-grade gliomas and in 4 (50%) of 8 low-grade gliomas. Hemangioblastomas showed the highest rCBV and lymphomas the lowest.

Conclusion: Perfusion MR imaging may be helpful in the differentiation of thevarious solid tumors found in the brain, and in assessing the grade of the various glial tumors occurring there.

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Related in: MedlinePlus

Solid hemangioblastoma in a 62-year-old woman. Conventional T2-weighted MR image (A) shows that in the left cerebellum, a lobulated mass with inhomogeneously high signal intensity is present. Enhanced T1-weighted MR image (B) shows strong enhancement. rCBV map (C) demonstrates very high rCBV (ratio, 40.75).
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Figure 5: Solid hemangioblastoma in a 62-year-old woman. Conventional T2-weighted MR image (A) shows that in the left cerebellum, a lobulated mass with inhomogeneously high signal intensity is present. Enhanced T1-weighted MR image (B) shows strong enhancement. rCBV map (C) demonstrates very high rCBV (ratio, 40.75).

Mentions: rCBV mapping demonstrated high rCBV in all hemangioblastomas, which at contrast-enhanced T1-weighted imaging showed strong contrast enhancement (Fig. 5). In all lymphomas, on the other hand, low rCBV and strong homogeneous enhancement were apparent. High rCBVs were found in six of seven metastases, each of the two germinomas, each of the two medulloblastomas, the ganglioglioma, and the choroid plexus papilloma. The pineal parenchymal tumor showed low rCBV and contrast enhancement.


Perfusion MR imaging: clinical utility for the differential diagnosis of various brain tumors.

Cho SK, Na DG, Ryoo JW, Roh HG, Moon CH, Byun HS, Kim JH - Korean J Radiol (2002 Jul-Sep)

Solid hemangioblastoma in a 62-year-old woman. Conventional T2-weighted MR image (A) shows that in the left cerebellum, a lobulated mass with inhomogeneously high signal intensity is present. Enhanced T1-weighted MR image (B) shows strong enhancement. rCBV map (C) demonstrates very high rCBV (ratio, 40.75).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2713881&req=5

Figure 5: Solid hemangioblastoma in a 62-year-old woman. Conventional T2-weighted MR image (A) shows that in the left cerebellum, a lobulated mass with inhomogeneously high signal intensity is present. Enhanced T1-weighted MR image (B) shows strong enhancement. rCBV map (C) demonstrates very high rCBV (ratio, 40.75).
Mentions: rCBV mapping demonstrated high rCBV in all hemangioblastomas, which at contrast-enhanced T1-weighted imaging showed strong contrast enhancement (Fig. 5). In all lymphomas, on the other hand, low rCBV and strong homogeneous enhancement were apparent. High rCBVs were found in six of seven metastases, each of the two germinomas, each of the two medulloblastomas, the ganglioglioma, and the choroid plexus papilloma. The pineal parenchymal tumor showed low rCBV and contrast enhancement.

Bottom Line: The highest rCBV ratios were seen in hemangioblastomas, followed by high-grade gliomas, metastases, low-grade gliomas, and lymphomas.At visual assessment, rCBV was high in 17 (81%) of 21 high-grade gliomas and in 4 (50%) of 8 low-grade gliomas.Hemangioblastomas showed the highest rCBV and lymphomas the lowest.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Objective: To determine the utility of perfusion MR imaging in the differential diagnosis of brain tumors.

Materials and methods: Fifty-seven patients with pathologically proven brain tumors (21 high-grade gliomas, 8 low-grade gliomas, 8 lymphomas, 6 hemangioblastomas, 7 metastases, and 7 various other tumors) were included in this study. Relative cerebral blood volume (rCBV) and time-to-peak (TTP) ratios were quantitatively analyzed and the rCBV grade of each tumor was also visually assessed on an rCBV map.

Results: The highest rCBV ratios were seen in hemangioblastomas, followed by high-grade gliomas, metastases, low-grade gliomas, and lymphomas. There was no significant difference in TTP ratios between each tumor group (p<0.05). At visual assessment, rCBV was high in 17 (81%) of 21 high-grade gliomas and in 4 (50%) of 8 low-grade gliomas. Hemangioblastomas showed the highest rCBV and lymphomas the lowest.

Conclusion: Perfusion MR imaging may be helpful in the differentiation of thevarious solid tumors found in the brain, and in assessing the grade of the various glial tumors occurring there.

Show MeSH
Related in: MedlinePlus