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Perfusion MR imaging: clinical utility for the differential diagnosis of various brain tumors.

Cho SK, Na DG, Ryoo JW, Roh HG, Moon CH, Byun HS, Kim JH - Korean J Radiol (2002 Jul-Sep)

Bottom Line: The highest rCBV ratios were seen in hemangioblastomas, followed by high-grade gliomas, metastases, low-grade gliomas, and lymphomas.At visual assessment, rCBV was high in 17 (81%) of 21 high-grade gliomas and in 4 (50%) of 8 low-grade gliomas.Hemangioblastomas showed the highest rCBV and lymphomas the lowest.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Objective: To determine the utility of perfusion MR imaging in the differential diagnosis of brain tumors.

Materials and methods: Fifty-seven patients with pathologically proven brain tumors (21 high-grade gliomas, 8 low-grade gliomas, 8 lymphomas, 6 hemangioblastomas, 7 metastases, and 7 various other tumors) were included in this study. Relative cerebral blood volume (rCBV) and time-to-peak (TTP) ratios were quantitatively analyzed and the rCBV grade of each tumor was also visually assessed on an rCBV map.

Results: The highest rCBV ratios were seen in hemangioblastomas, followed by high-grade gliomas, metastases, low-grade gliomas, and lymphomas. There was no significant difference in TTP ratios between each tumor group (p<0.05). At visual assessment, rCBV was high in 17 (81%) of 21 high-grade gliomas and in 4 (50%) of 8 low-grade gliomas. Hemangioblastomas showed the highest rCBV and lymphomas the lowest.

Conclusion: Perfusion MR imaging may be helpful in the differentiation of thevarious solid tumors found in the brain, and in assessing the grade of the various glial tumors occurring there.

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Related in: MedlinePlus

Metastatic squamous cell carcinoma of the lung in a 56-year-old man. Conventional T2-weighted MR image (A) demonstrates a lobulated mass with intermediate signal intensity in the right cerebellum. Enhanced T1-weighted MR image (B) shows relatively strong enhancement. rCBV map (C) depicts the tumor's relatively high rCBV, the ratio of which was 7.88.
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Figure 4: Metastatic squamous cell carcinoma of the lung in a 56-year-old man. Conventional T2-weighted MR image (A) demonstrates a lobulated mass with intermediate signal intensity in the right cerebellum. Enhanced T1-weighted MR image (B) shows relatively strong enhancement. rCBV map (C) depicts the tumor's relatively high rCBV, the ratio of which was 7.88.

Mentions: rCBV and TTP ratios are summarized in Tables 1 and 2. For high- and low-grade gliomas, these varied from 3.02 to 16.66 (mean ± SD, 9.33 ± 3.96) and from 1.30 to 5.07 (mean ± SD, 3.64 ± 1.50), respectively (Figs. 1, 2). The difference was statistically significant (p=0.001, Student's t test). In general, the rCBV ratios of high-grade gliomas of a specific histologic type were not significantly different from those of other high-grade gliomas, and this was also the case with low-grade gliomas. Hemangioblastomas showed the highest rCBV ratios (mean, 26.60 ± 8.98), which was statistically higher than those of all other tumors (p<0.001). The rCBV ratios of metastases varied from 3.16 to 13.27 (mean, 8.34 ± 3.02), a finding similar to that for high-grade gliomas. Lymphomas had low rCBV ratios (Fig. 3), ranging from 1.38 to 2.07, values which were significantly lower than those of high-grade gliomas (p=0.001) or metastases (p=0.032) (Fig. 4).


Perfusion MR imaging: clinical utility for the differential diagnosis of various brain tumors.

Cho SK, Na DG, Ryoo JW, Roh HG, Moon CH, Byun HS, Kim JH - Korean J Radiol (2002 Jul-Sep)

Metastatic squamous cell carcinoma of the lung in a 56-year-old man. Conventional T2-weighted MR image (A) demonstrates a lobulated mass with intermediate signal intensity in the right cerebellum. Enhanced T1-weighted MR image (B) shows relatively strong enhancement. rCBV map (C) depicts the tumor's relatively high rCBV, the ratio of which was 7.88.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2713881&req=5

Figure 4: Metastatic squamous cell carcinoma of the lung in a 56-year-old man. Conventional T2-weighted MR image (A) demonstrates a lobulated mass with intermediate signal intensity in the right cerebellum. Enhanced T1-weighted MR image (B) shows relatively strong enhancement. rCBV map (C) depicts the tumor's relatively high rCBV, the ratio of which was 7.88.
Mentions: rCBV and TTP ratios are summarized in Tables 1 and 2. For high- and low-grade gliomas, these varied from 3.02 to 16.66 (mean ± SD, 9.33 ± 3.96) and from 1.30 to 5.07 (mean ± SD, 3.64 ± 1.50), respectively (Figs. 1, 2). The difference was statistically significant (p=0.001, Student's t test). In general, the rCBV ratios of high-grade gliomas of a specific histologic type were not significantly different from those of other high-grade gliomas, and this was also the case with low-grade gliomas. Hemangioblastomas showed the highest rCBV ratios (mean, 26.60 ± 8.98), which was statistically higher than those of all other tumors (p<0.001). The rCBV ratios of metastases varied from 3.16 to 13.27 (mean, 8.34 ± 3.02), a finding similar to that for high-grade gliomas. Lymphomas had low rCBV ratios (Fig. 3), ranging from 1.38 to 2.07, values which were significantly lower than those of high-grade gliomas (p=0.001) or metastases (p=0.032) (Fig. 4).

Bottom Line: The highest rCBV ratios were seen in hemangioblastomas, followed by high-grade gliomas, metastases, low-grade gliomas, and lymphomas.At visual assessment, rCBV was high in 17 (81%) of 21 high-grade gliomas and in 4 (50%) of 8 low-grade gliomas.Hemangioblastomas showed the highest rCBV and lymphomas the lowest.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Objective: To determine the utility of perfusion MR imaging in the differential diagnosis of brain tumors.

Materials and methods: Fifty-seven patients with pathologically proven brain tumors (21 high-grade gliomas, 8 low-grade gliomas, 8 lymphomas, 6 hemangioblastomas, 7 metastases, and 7 various other tumors) were included in this study. Relative cerebral blood volume (rCBV) and time-to-peak (TTP) ratios were quantitatively analyzed and the rCBV grade of each tumor was also visually assessed on an rCBV map.

Results: The highest rCBV ratios were seen in hemangioblastomas, followed by high-grade gliomas, metastases, low-grade gliomas, and lymphomas. There was no significant difference in TTP ratios between each tumor group (p<0.05). At visual assessment, rCBV was high in 17 (81%) of 21 high-grade gliomas and in 4 (50%) of 8 low-grade gliomas. Hemangioblastomas showed the highest rCBV and lymphomas the lowest.

Conclusion: Perfusion MR imaging may be helpful in the differentiation of thevarious solid tumors found in the brain, and in assessing the grade of the various glial tumors occurring there.

Show MeSH
Related in: MedlinePlus