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Saline-enhanced radiofrequency thermal ablation of the lung: a feasibility study in rabbits.

Lee JM, Kim SW, Li CA, Youk JH, Kim YK, Jin Z, Chung MJ, Lee MS - Korean J Radiol (2002 Oct-Dec)

Bottom Line: In the SRFA group, 1.5 ml of 0.9% saline was infused slowly through a 21-gauge, polyteflon- coated Chiba needle prior to and during RFA.In the SRFA group, the mean diameter (12.5+/-1.6 mm) of acute RF lesions was greater than that of RFA lesions (8.5+/-1.4 mm) (p < .05).Although procedure-related complications tended to occur more frequently in the SRFA group (55.6%) than in the RFA group (20%), the difference was not statistically significant (p = .11).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Chonbuk National University Medical School, Korea. jmlshy@naver.com

ABSTRACT

Objective: To assess the feasibility and safety of CT-guided percutaneous transthoracic radiofrequency ablation (RFA) with saline infusion of pulmonary tissue in rabbits.

Materials and methods: Twenty-eight New Zealand White rabbits were divided into two groups: an RFA group (n=10) and a saline-enhanced RFA (SRFA) group (n=18). In the RFA group, percutaneous RFA of the lung was performed under CT guidance and using a 17-gauge internally cooled electrode. In the SRFA group, 1.5 ml of 0.9% saline was infused slowly through a 21-gauge, polyteflon- coated Chiba needle prior to and during RFA. Lesion size and the healing process were studied in rabbits sacrificed at times from the day following treatment to three weeks after, and any complications were noted.

Results: In the SRFA group, the mean diameter (12.5+/-1.6 mm) of acute RF lesions was greater than that of RFA lesions (8.5+/-1.4 mm) (p < .05). The complications arising in 12 cases were pneumothorax (n=8), thermal injury to the chest wall (n=2), hemothorax (n=1), and lung abscess (n=1). Although procedure-related complications tended to occur more frequently in the SRFA group (55.6%) than in the RFA group (20%), the difference was not statistically significant (p = .11).

Conclusion: Saline-enhanced RFA of pulmonary tissue in rabbits produces more extensive coagulation necrosis than conventional RFA procedures, without adding substantial risk of serious complications.

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Related in: MedlinePlus

Radiofrequency ablation in a rabbit in the radiofrequency group.A. Computed tomographic section obtained during radiofrequcy ablation. The right lower lobe is penetrated posteriorly by an electrode along which an ovoid opacity extends (arrows).B. Contrast-enhanced CT scan obtained after the procedure depicts nonenhancing opacity (arrows) in the central portion of the right lobe. Note good enhancement of the pulmonary vessels in the area of ablation.C. Gross specimen demonstrates an 8-mm central zone of coagulation necrosis surrounded by a dark-brown, 1-mm-thick hemorrhagic rim.D. Microscopic image of the central ablation zone (A) shows that this contains pyknotic nuclei and eosinophilic cytoplasm, and that hemorrhagic congestion (arrows) has occurred at the border between the ablation area and normal pulmonary parenchyma (P).
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Figure 1: Radiofrequency ablation in a rabbit in the radiofrequency group.A. Computed tomographic section obtained during radiofrequcy ablation. The right lower lobe is penetrated posteriorly by an electrode along which an ovoid opacity extends (arrows).B. Contrast-enhanced CT scan obtained after the procedure depicts nonenhancing opacity (arrows) in the central portion of the right lobe. Note good enhancement of the pulmonary vessels in the area of ablation.C. Gross specimen demonstrates an 8-mm central zone of coagulation necrosis surrounded by a dark-brown, 1-mm-thick hemorrhagic rim.D. Microscopic image of the central ablation zone (A) shows that this contains pyknotic nuclei and eosinophilic cytoplasm, and that hemorrhagic congestion (arrows) has occurred at the border between the ablation area and normal pulmonary parenchyma (P).

Mentions: After RFA, unenhanced CT scanning revealed circumscribed hyperattenuated regions extending 5-8 mm from the portion of the inserted electrode (Fig. 1), while contrast-enhanced CT showed no enhancement in the region of altered pulmonary attenuation. Greater conspicuity of coagulated tissues was observed at wide window settings (level=500 HU, width = 2000 HU).


Saline-enhanced radiofrequency thermal ablation of the lung: a feasibility study in rabbits.

Lee JM, Kim SW, Li CA, Youk JH, Kim YK, Jin Z, Chung MJ, Lee MS - Korean J Radiol (2002 Oct-Dec)

Radiofrequency ablation in a rabbit in the radiofrequency group.A. Computed tomographic section obtained during radiofrequcy ablation. The right lower lobe is penetrated posteriorly by an electrode along which an ovoid opacity extends (arrows).B. Contrast-enhanced CT scan obtained after the procedure depicts nonenhancing opacity (arrows) in the central portion of the right lobe. Note good enhancement of the pulmonary vessels in the area of ablation.C. Gross specimen demonstrates an 8-mm central zone of coagulation necrosis surrounded by a dark-brown, 1-mm-thick hemorrhagic rim.D. Microscopic image of the central ablation zone (A) shows that this contains pyknotic nuclei and eosinophilic cytoplasm, and that hemorrhagic congestion (arrows) has occurred at the border between the ablation area and normal pulmonary parenchyma (P).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2713847&req=5

Figure 1: Radiofrequency ablation in a rabbit in the radiofrequency group.A. Computed tomographic section obtained during radiofrequcy ablation. The right lower lobe is penetrated posteriorly by an electrode along which an ovoid opacity extends (arrows).B. Contrast-enhanced CT scan obtained after the procedure depicts nonenhancing opacity (arrows) in the central portion of the right lobe. Note good enhancement of the pulmonary vessels in the area of ablation.C. Gross specimen demonstrates an 8-mm central zone of coagulation necrosis surrounded by a dark-brown, 1-mm-thick hemorrhagic rim.D. Microscopic image of the central ablation zone (A) shows that this contains pyknotic nuclei and eosinophilic cytoplasm, and that hemorrhagic congestion (arrows) has occurred at the border between the ablation area and normal pulmonary parenchyma (P).
Mentions: After RFA, unenhanced CT scanning revealed circumscribed hyperattenuated regions extending 5-8 mm from the portion of the inserted electrode (Fig. 1), while contrast-enhanced CT showed no enhancement in the region of altered pulmonary attenuation. Greater conspicuity of coagulated tissues was observed at wide window settings (level=500 HU, width = 2000 HU).

Bottom Line: In the SRFA group, 1.5 ml of 0.9% saline was infused slowly through a 21-gauge, polyteflon- coated Chiba needle prior to and during RFA.In the SRFA group, the mean diameter (12.5+/-1.6 mm) of acute RF lesions was greater than that of RFA lesions (8.5+/-1.4 mm) (p < .05).Although procedure-related complications tended to occur more frequently in the SRFA group (55.6%) than in the RFA group (20%), the difference was not statistically significant (p = .11).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Chonbuk National University Medical School, Korea. jmlshy@naver.com

ABSTRACT

Objective: To assess the feasibility and safety of CT-guided percutaneous transthoracic radiofrequency ablation (RFA) with saline infusion of pulmonary tissue in rabbits.

Materials and methods: Twenty-eight New Zealand White rabbits were divided into two groups: an RFA group (n=10) and a saline-enhanced RFA (SRFA) group (n=18). In the RFA group, percutaneous RFA of the lung was performed under CT guidance and using a 17-gauge internally cooled electrode. In the SRFA group, 1.5 ml of 0.9% saline was infused slowly through a 21-gauge, polyteflon- coated Chiba needle prior to and during RFA. Lesion size and the healing process were studied in rabbits sacrificed at times from the day following treatment to three weeks after, and any complications were noted.

Results: In the SRFA group, the mean diameter (12.5+/-1.6 mm) of acute RF lesions was greater than that of RFA lesions (8.5+/-1.4 mm) (p < .05). The complications arising in 12 cases were pneumothorax (n=8), thermal injury to the chest wall (n=2), hemothorax (n=1), and lung abscess (n=1). Although procedure-related complications tended to occur more frequently in the SRFA group (55.6%) than in the RFA group (20%), the difference was not statistically significant (p = .11).

Conclusion: Saline-enhanced RFA of pulmonary tissue in rabbits produces more extensive coagulation necrosis than conventional RFA procedures, without adding substantial risk of serious complications.

Show MeSH
Related in: MedlinePlus