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The significance of perfusion defect at myocardial perfusion MR imaging in a cat model of acute reperfused myocardial infarction.

Goo HW, Kim DH, Lee SS, Park SB, Lim TH - Korean J Radiol (2002 Oct-Dec)

Bottom Line: In nine cats, reperfused myocardial infarction was induced by occlusion of the left anterior descending coronary artery for 90 minutes and subsequent reperfusion for 90 minutes.At single-slice myocardial perfusion MR imaging at the midventricular level using a turbo-FLASH sequence, 60 short-axis images were sequentially obtained with every heart beat after bolus injection of gadomer-17.The defect may represent a more severely damaged area of infarction and probably has prognostic significance.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Asan Medical Center, University of Ulsan Collge of Medicine, Seoul, Korea. thlim@www.amc.seoul.kr

ABSTRACT

Objective: To determine whether the size of a perfusion defect seen at myocardial perfusion MR imaging represents the extent of irreversibly damaged myocardium in acute reperfused myocardial infarction.

Materials and methods: In nine cats, reperfused myocardial infarction was induced by occlusion of the left anterior descending coronary artery for 90 minutes and subsequent reperfusion for 90 minutes. At single-slice myocardial perfusion MR imaging at the midventricular level using a turbo-FLASH sequence, 60 short-axis images were sequentially obtained with every heart beat after bolus injection of gadomer-17. The size of the perfusion defect was measured and compared with both the corresponding unstained area seen at triphenyl tetrazolium chloride (TTC) staining and the hyperenhanced area seen at gadophrin-2- enhanced MR imaging performed in the same cat six hours after myocardial perfusion MR imaging.

Results: The sizes of perfusion defects seen at gadomer-17-enhanced perfusion MR imaging, unstained areas at TTC staining, and hyperenhanced areas at gadophrin-2-enhanced MR imaging were 20.4+/-4.3%, 29.0+/-9.7%, and 30.7+/- 10.6% of the left ventricular myocardium, respectively. The perfusion defects seen at myocardial perfusion MR imaging were significantly smaller than the unstained areas at TTC staining and hyperenhanced areas at gadophrin-2- enhanced MR imaging (p < .01). The sizes of both the perfusion defect at myocardial perfusion MR imaging and the hyperenhanced area at gadophrin-2- enhanced MR imaging correlated well with the sizes of unstained areas at TTC staining (r = .64, p = .062 and r = .70, p = .035, respectively).

Conclusion: In this cat model, the perfusion defect revealed by myocardial perfusion MR imaging underestimated the true size of acute reperfused myocardial infarction. The defect may represent a more severely damaged area of infarction and probably has prognostic significance.

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Comparison of the size of perfusion defects at myocardial perfusion MR imaging (20.4 ± 4.3% of the area of the left ventricular myocardium [LVM]), hyperenhanced areas at gadophrin-2-enhanced MR imaging (30.7 ± 10.6%), and unstained areas at TTC staining (*) (29.0 ± 9.7%). The first mentioned was significantly smaller than the second and last (p < .01).
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Figure 2: Comparison of the size of perfusion defects at myocardial perfusion MR imaging (20.4 ± 4.3% of the area of the left ventricular myocardium [LVM]), hyperenhanced areas at gadophrin-2-enhanced MR imaging (30.7 ± 10.6%), and unstained areas at TTC staining (*) (29.0 ± 9.7%). The first mentioned was significantly smaller than the second and last (p < .01).

Mentions: At both MR imaging and TTC staining, all nine cats showed evidence of myocardial infarction in LAD territory. Although myocardial perfusion MR imaging showed lower spatial resolution, perfusion defects were also obvious and measurable. The sizes of these at gadomer-17-enhanced perfusion MR imaging, and of unstained areas at TTC staining and hyperenhanced areas at gadophrin-2-enhanced MR imaging were 20.4 ± 4.3%, 29.0 ± 9.7%, and 30.7 ± 10.6% of the LVM area, respectively (Fig. 2). The perfusion defects seen at myocardial perfusion MR imaging were significantly smaller than unstained areas at TTC staining and hyperenhanced areas at gadophrin-2-enhanced MR imaging (p < .01). The sizes of both the perfusion defect at myocardial perfusion MR imaging and the hyperenhanced area at gadophrin-2-enhanced MR imaging correlated well with the sizes of unstained areas at TTC staining (r = .64, p = .062 and r = .70, p = .035, respectively) (Fig. 3), though the statistical significance of this correlation was marginal.


The significance of perfusion defect at myocardial perfusion MR imaging in a cat model of acute reperfused myocardial infarction.

Goo HW, Kim DH, Lee SS, Park SB, Lim TH - Korean J Radiol (2002 Oct-Dec)

Comparison of the size of perfusion defects at myocardial perfusion MR imaging (20.4 ± 4.3% of the area of the left ventricular myocardium [LVM]), hyperenhanced areas at gadophrin-2-enhanced MR imaging (30.7 ± 10.6%), and unstained areas at TTC staining (*) (29.0 ± 9.7%). The first mentioned was significantly smaller than the second and last (p < .01).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2713845&req=5

Figure 2: Comparison of the size of perfusion defects at myocardial perfusion MR imaging (20.4 ± 4.3% of the area of the left ventricular myocardium [LVM]), hyperenhanced areas at gadophrin-2-enhanced MR imaging (30.7 ± 10.6%), and unstained areas at TTC staining (*) (29.0 ± 9.7%). The first mentioned was significantly smaller than the second and last (p < .01).
Mentions: At both MR imaging and TTC staining, all nine cats showed evidence of myocardial infarction in LAD territory. Although myocardial perfusion MR imaging showed lower spatial resolution, perfusion defects were also obvious and measurable. The sizes of these at gadomer-17-enhanced perfusion MR imaging, and of unstained areas at TTC staining and hyperenhanced areas at gadophrin-2-enhanced MR imaging were 20.4 ± 4.3%, 29.0 ± 9.7%, and 30.7 ± 10.6% of the LVM area, respectively (Fig. 2). The perfusion defects seen at myocardial perfusion MR imaging were significantly smaller than unstained areas at TTC staining and hyperenhanced areas at gadophrin-2-enhanced MR imaging (p < .01). The sizes of both the perfusion defect at myocardial perfusion MR imaging and the hyperenhanced area at gadophrin-2-enhanced MR imaging correlated well with the sizes of unstained areas at TTC staining (r = .64, p = .062 and r = .70, p = .035, respectively) (Fig. 3), though the statistical significance of this correlation was marginal.

Bottom Line: In nine cats, reperfused myocardial infarction was induced by occlusion of the left anterior descending coronary artery for 90 minutes and subsequent reperfusion for 90 minutes.At single-slice myocardial perfusion MR imaging at the midventricular level using a turbo-FLASH sequence, 60 short-axis images were sequentially obtained with every heart beat after bolus injection of gadomer-17.The defect may represent a more severely damaged area of infarction and probably has prognostic significance.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Asan Medical Center, University of Ulsan Collge of Medicine, Seoul, Korea. thlim@www.amc.seoul.kr

ABSTRACT

Objective: To determine whether the size of a perfusion defect seen at myocardial perfusion MR imaging represents the extent of irreversibly damaged myocardium in acute reperfused myocardial infarction.

Materials and methods: In nine cats, reperfused myocardial infarction was induced by occlusion of the left anterior descending coronary artery for 90 minutes and subsequent reperfusion for 90 minutes. At single-slice myocardial perfusion MR imaging at the midventricular level using a turbo-FLASH sequence, 60 short-axis images were sequentially obtained with every heart beat after bolus injection of gadomer-17. The size of the perfusion defect was measured and compared with both the corresponding unstained area seen at triphenyl tetrazolium chloride (TTC) staining and the hyperenhanced area seen at gadophrin-2- enhanced MR imaging performed in the same cat six hours after myocardial perfusion MR imaging.

Results: The sizes of perfusion defects seen at gadomer-17-enhanced perfusion MR imaging, unstained areas at TTC staining, and hyperenhanced areas at gadophrin-2-enhanced MR imaging were 20.4+/-4.3%, 29.0+/-9.7%, and 30.7+/- 10.6% of the left ventricular myocardium, respectively. The perfusion defects seen at myocardial perfusion MR imaging were significantly smaller than the unstained areas at TTC staining and hyperenhanced areas at gadophrin-2- enhanced MR imaging (p < .01). The sizes of both the perfusion defect at myocardial perfusion MR imaging and the hyperenhanced area at gadophrin-2- enhanced MR imaging correlated well with the sizes of unstained areas at TTC staining (r = .64, p = .062 and r = .70, p = .035, respectively).

Conclusion: In this cat model, the perfusion defect revealed by myocardial perfusion MR imaging underestimated the true size of acute reperfused myocardial infarction. The defect may represent a more severely damaged area of infarction and probably has prognostic significance.

Show MeSH
Related in: MedlinePlus