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In-vivo proton magnetic resonance spectroscopy in adnexal lesions.

Cho SW, Cho SG, Lee JH, Kim HJ, Lim MK, Kim JH, Suh CH - Korean J Radiol (2002 Apr-Jun)

Bottom Line: The methylene present in fatty acid chains gave rise to a lipid peak of 1.3 ppm in the 1H- MR spectra of most malignant tumors and benign teratomas.This same peak was not observed, however, in the spectra of benign ovarian epithelial tumors: in a number of these, a peak of 5.2 ppm, due to the presence of the olefine group (-CH=CH-) was noted.The ratios of lipid peak at 1.3 ppm to water peak (lipid/water ratios) varied between disease groups, and in some benign teratomas was characteristically high.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Inha University College of Medicine, Incheon, South Korea.

ABSTRACT

Objective: To explore the in-vivo 1H- MR spectral features of adnexal lesions and to characterize the spectral patterns of various pathologic entities.

Materials and methods: Thirty-one patients with surgically and histopathologically confirmed adnexal lesions underwent short echo-time STEAM (stimulated echo acquisition method) 1H- MR spectroscopy, and the results obtained were analysed.

Results: The methylene present in fatty acid chains gave rise to a lipid peak of 1.3 ppm in the 1H- MR spectra of most malignant tumors and benign teratomas. This same peak was not observed, however, in the spectra of benign ovarian epithelial tumors: in a number of these, a peak of 5.2 ppm, due to the presence of the olefine group (-CH=CH-) was noted. The ratios of lipid peak at 1.3 ppm to water peak (lipid/water ratios) varied between disease groups, and in some benign teratomas was characteristically high.

Conclusion: An intense lipid peak at 1.3 ppm is observed in malignant ovarian tumors but not in benign epithelial tumors. 1H- MRS may therefore be helpful in the differential diagnosis of adnexal lesions.

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Patient 11. Mucinous cystadenoma in a 28-year-old woman. (A) Post-contrast CT scan and (B) axial scanogram obtained using 1H- MRS demonstrate a large multiseptated cystic pelvic mass. There was no prominent lipid peak at 1.3 ppm in either (C) water-unsuppressed or (D) water-suppressed spectra, and the lipid-to-water ratio was unavailable.
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Figure 3: Patient 11. Mucinous cystadenoma in a 28-year-old woman. (A) Post-contrast CT scan and (B) axial scanogram obtained using 1H- MRS demonstrate a large multiseptated cystic pelvic mass. There was no prominent lipid peak at 1.3 ppm in either (C) water-unsuppressed or (D) water-suppressed spectra, and the lipid-to-water ratio was unavailable.

Mentions: A resonance peak at 1.3 ppm, caused by the presence of the methylene group in fatty acid chains, was observed in five of the seven malignant ovarian tumors and seven of the eleven benign teratomas (Figs. 1, 4), as well as in one borderline malignant tumor and the case of salpingitis (Fig. 2). Interestingly, whereas most primary and secondary malignant ovarian tumors showed an intense lipid peak at 1.3 ppm, this same peak was not observed in the MR spectra of any of the six benign ovarian epithelial tumors (Fig. 3). Thus, the incidence of a lipid peak was significantly higher in malignant tumors than in benign epithelial tumors (p < 0.05). A lipid peak at 5.2 ppm, due to the presence of the olefine group in fatty acid chains, was observed in two cases of the eleven benign teratomas, one of the four endometrioses, and the ectopic pregnancy. The 1H- MR spectra of benign ovarian epithelial tumors showed no detectable lipid peak at 1.3 or 5.2 ppm (Tables 1, 2).


In-vivo proton magnetic resonance spectroscopy in adnexal lesions.

Cho SW, Cho SG, Lee JH, Kim HJ, Lim MK, Kim JH, Suh CH - Korean J Radiol (2002 Apr-Jun)

Patient 11. Mucinous cystadenoma in a 28-year-old woman. (A) Post-contrast CT scan and (B) axial scanogram obtained using 1H- MRS demonstrate a large multiseptated cystic pelvic mass. There was no prominent lipid peak at 1.3 ppm in either (C) water-unsuppressed or (D) water-suppressed spectra, and the lipid-to-water ratio was unavailable.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2713833&req=5

Figure 3: Patient 11. Mucinous cystadenoma in a 28-year-old woman. (A) Post-contrast CT scan and (B) axial scanogram obtained using 1H- MRS demonstrate a large multiseptated cystic pelvic mass. There was no prominent lipid peak at 1.3 ppm in either (C) water-unsuppressed or (D) water-suppressed spectra, and the lipid-to-water ratio was unavailable.
Mentions: A resonance peak at 1.3 ppm, caused by the presence of the methylene group in fatty acid chains, was observed in five of the seven malignant ovarian tumors and seven of the eleven benign teratomas (Figs. 1, 4), as well as in one borderline malignant tumor and the case of salpingitis (Fig. 2). Interestingly, whereas most primary and secondary malignant ovarian tumors showed an intense lipid peak at 1.3 ppm, this same peak was not observed in the MR spectra of any of the six benign ovarian epithelial tumors (Fig. 3). Thus, the incidence of a lipid peak was significantly higher in malignant tumors than in benign epithelial tumors (p < 0.05). A lipid peak at 5.2 ppm, due to the presence of the olefine group in fatty acid chains, was observed in two cases of the eleven benign teratomas, one of the four endometrioses, and the ectopic pregnancy. The 1H- MR spectra of benign ovarian epithelial tumors showed no detectable lipid peak at 1.3 or 5.2 ppm (Tables 1, 2).

Bottom Line: The methylene present in fatty acid chains gave rise to a lipid peak of 1.3 ppm in the 1H- MR spectra of most malignant tumors and benign teratomas.This same peak was not observed, however, in the spectra of benign ovarian epithelial tumors: in a number of these, a peak of 5.2 ppm, due to the presence of the olefine group (-CH=CH-) was noted.The ratios of lipid peak at 1.3 ppm to water peak (lipid/water ratios) varied between disease groups, and in some benign teratomas was characteristically high.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Inha University College of Medicine, Incheon, South Korea.

ABSTRACT

Objective: To explore the in-vivo 1H- MR spectral features of adnexal lesions and to characterize the spectral patterns of various pathologic entities.

Materials and methods: Thirty-one patients with surgically and histopathologically confirmed adnexal lesions underwent short echo-time STEAM (stimulated echo acquisition method) 1H- MR spectroscopy, and the results obtained were analysed.

Results: The methylene present in fatty acid chains gave rise to a lipid peak of 1.3 ppm in the 1H- MR spectra of most malignant tumors and benign teratomas. This same peak was not observed, however, in the spectra of benign ovarian epithelial tumors: in a number of these, a peak of 5.2 ppm, due to the presence of the olefine group (-CH=CH-) was noted. The ratios of lipid peak at 1.3 ppm to water peak (lipid/water ratios) varied between disease groups, and in some benign teratomas was characteristically high.

Conclusion: An intense lipid peak at 1.3 ppm is observed in malignant ovarian tumors but not in benign epithelial tumors. 1H- MRS may therefore be helpful in the differential diagnosis of adnexal lesions.

Show MeSH
Related in: MedlinePlus