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Correlation of flicker-induced and flow-mediated vasodilatation in patients with endothelial dysfunction and healthy volunteers.

Pemp B, Weigert G, Karl K, Petzl U, Wolzt M, Schmetterer L, Garhofer G - Diabetes Care (2009)

Bottom Line: RESULTS The flicker response of both retinal arteries and veins was significantly reduced in the two patients groups.Likewise, FMD was significantly reduced in patients compared with healthy control subjects.CONCLUSIONS The study confirms that flicker responses and FMD are reduced in the selected patient groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

ABSTRACT
OBJECTIVE Flicker-induced vasodilatation is reduced in patients with vascular-related diseases, which has at least partially been attributed to endothelial dysfunction of retinal vessels. Currently, the standard method to assess endothelial function in vivo is flow-mediated vasodilatation (FMD). Thus, the present study was performed to investigate whether a correlation exists between flicker-induced vasodilatation and FMD in patients with known endothelial dysfunction and healthy subjects. RESEARCH DESIGN AND METHODS In the present study, 20 patients with type 1 diabetes, 40 patients with systemic hypertension (systolic blood pressure 140-159 mmHg; diastolic blood pressure 90-99 mmHg) and/or serum cholesterol levels > or =0.65 mmol/l, and 20 healthy control subjects were included. The flicker response was measured using the Dynamic Retinal Vessel Analyzer. FMD was determined using a high-resolution ultrasound system, measuring brachial artery diameter reactivity during reperfusion after arterial occlusion. RESULTS The flicker response of both retinal arteries and veins was significantly reduced in the two patients groups. Likewise, FMD was significantly reduced in patients compared with healthy control subjects. However, only a weak correlation between flicker-induced vasodilatation and FMD was observed. CONCLUSIONS The study confirms that flicker responses and FMD are reduced in the selected patient groups. Whether the weak correlation between FMD and flicker is due to the different stimulation type, the different vascular beds measured, or other mechanisms has yet to be investigated.

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Correlation analysis between flicker-induced vasodilatation and plasma cholesterol levels (r = −0.33, P = 0.044) (A), between FMD and age (r = −0.35, P = 0.081) (D), and vice versa (r = −0.33, P = 0.08) (B) (r = −0.22, P = 0.090) (C).
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Figure 3: Correlation analysis between flicker-induced vasodilatation and plasma cholesterol levels (r = −0.33, P = 0.044) (A), between FMD and age (r = −0.35, P = 0.081) (D), and vice versa (r = −0.33, P = 0.08) (B) (r = −0.22, P = 0.090) (C).

Mentions: A correlation between FMD and flicker-induced vasodilatation in retinal arteries (r = 0.3, P = 0.044) was found (Fig. 2 ). No correlation, however, was observed between FMD and flicker response in retinal veins (data not shown). Flicker-induced vasodilatation was negatively correlated with plasma cholesterol levels (r = −0.33, P = 0.044) but not with age (r = −0.33, P = 0.08) (Fig. 3 ). There was also no significant correlation between FMD and age (r = −0.35, P = 0.081) or cholesterol (r = −0.22, P = 0.090) after P value adjustment. Given that patients with diabetes are known to have a reduced flicker response, the type 1 diabetic group has been excluded in the latter analyses.


Correlation of flicker-induced and flow-mediated vasodilatation in patients with endothelial dysfunction and healthy volunteers.

Pemp B, Weigert G, Karl K, Petzl U, Wolzt M, Schmetterer L, Garhofer G - Diabetes Care (2009)

Correlation analysis between flicker-induced vasodilatation and plasma cholesterol levels (r = −0.33, P = 0.044) (A), between FMD and age (r = −0.35, P = 0.081) (D), and vice versa (r = −0.33, P = 0.08) (B) (r = −0.22, P = 0.090) (C).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2713642&req=5

Figure 3: Correlation analysis between flicker-induced vasodilatation and plasma cholesterol levels (r = −0.33, P = 0.044) (A), between FMD and age (r = −0.35, P = 0.081) (D), and vice versa (r = −0.33, P = 0.08) (B) (r = −0.22, P = 0.090) (C).
Mentions: A correlation between FMD and flicker-induced vasodilatation in retinal arteries (r = 0.3, P = 0.044) was found (Fig. 2 ). No correlation, however, was observed between FMD and flicker response in retinal veins (data not shown). Flicker-induced vasodilatation was negatively correlated with plasma cholesterol levels (r = −0.33, P = 0.044) but not with age (r = −0.33, P = 0.08) (Fig. 3 ). There was also no significant correlation between FMD and age (r = −0.35, P = 0.081) or cholesterol (r = −0.22, P = 0.090) after P value adjustment. Given that patients with diabetes are known to have a reduced flicker response, the type 1 diabetic group has been excluded in the latter analyses.

Bottom Line: RESULTS The flicker response of both retinal arteries and veins was significantly reduced in the two patients groups.Likewise, FMD was significantly reduced in patients compared with healthy control subjects.CONCLUSIONS The study confirms that flicker responses and FMD are reduced in the selected patient groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

ABSTRACT
OBJECTIVE Flicker-induced vasodilatation is reduced in patients with vascular-related diseases, which has at least partially been attributed to endothelial dysfunction of retinal vessels. Currently, the standard method to assess endothelial function in vivo is flow-mediated vasodilatation (FMD). Thus, the present study was performed to investigate whether a correlation exists between flicker-induced vasodilatation and FMD in patients with known endothelial dysfunction and healthy subjects. RESEARCH DESIGN AND METHODS In the present study, 20 patients with type 1 diabetes, 40 patients with systemic hypertension (systolic blood pressure 140-159 mmHg; diastolic blood pressure 90-99 mmHg) and/or serum cholesterol levels > or =0.65 mmol/l, and 20 healthy control subjects were included. The flicker response was measured using the Dynamic Retinal Vessel Analyzer. FMD was determined using a high-resolution ultrasound system, measuring brachial artery diameter reactivity during reperfusion after arterial occlusion. RESULTS The flicker response of both retinal arteries and veins was significantly reduced in the two patients groups. Likewise, FMD was significantly reduced in patients compared with healthy control subjects. However, only a weak correlation between flicker-induced vasodilatation and FMD was observed. CONCLUSIONS The study confirms that flicker responses and FMD are reduced in the selected patient groups. Whether the weak correlation between FMD and flicker is due to the different stimulation type, the different vascular beds measured, or other mechanisms has yet to be investigated.

Show MeSH
Related in: MedlinePlus