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Long-range correlations in rectal temperature fluctuations of healthy infants during maturation.

Stern G, Beel J, Suki B, Silverman M, Westaway J, Cernelc M, Baldwin D, Frey U - PLoS ONE (2009)

Bottom Line: We thus aimed to investigate the existence of fractal-like long-range correlations, indicative of temperature control, in night time rectal temperature (T(rec)) patterns in maturing infants.The effects of maturation, room temperature, and immunization on the strength of correlation were investigated.A significant increase in alpha with age from 1.42 (0.07) at 4 weeks to 1.58 (0.04) at 20 weeks reflects a change in long-range correlation behavior with maturation towards a smoother and more deterministic temperature regulation, potentially due to the decrease in surface area to body weight ratio in the maturing infant. alpha was not associated with mean room temperature or influenced by immunization This study shows that the quantification of long-range correlations using alpha derived from detrended fluctuation analysis is an observer-independent tool which can distinguish developmental stages of night time T(rec) pattern in young infants, reflective of maturation of the autonomic system.

View Article: PubMed Central - PubMed

Affiliation: Division of Respiratory Medicine, Department of Pediatrics, Inselspital and University of Bern, Bern, Switzerland. georgette.stern@insel.ch

ABSTRACT

Background: Control of breathing, heart rate, and body temperature are interdependent in infants, where instabilities in thermoregulation can contribute to apneas or even life-threatening events. Identifying abnormalities in thermoregulation is particularly important in the first 6 months of life, where autonomic regulation undergoes critical development. Fluctuations in body temperature have been shown to be sensitive to maturational stage as well as system failure in critically ill patients. We thus aimed to investigate the existence of fractal-like long-range correlations, indicative of temperature control, in night time rectal temperature (T(rec)) patterns in maturing infants.

Methodology/principal findings: We measured T(rec) fluctuations in infants every 4 weeks from 4 to 20 weeks of age and before and after immunization. Long-range correlations in the temperature series were quantified by the correlation exponent, alpha using detrended fluctuation analysis. The effects of maturation, room temperature, and immunization on the strength of correlation were investigated. We found that T(rec) fluctuations exhibit fractal long-range correlations with a mean (SD) alpha of 1.51 (0.11), indicating that T(rec) is regulated in a highly correlated and hence deterministic manner. A significant increase in alpha with age from 1.42 (0.07) at 4 weeks to 1.58 (0.04) at 20 weeks reflects a change in long-range correlation behavior with maturation towards a smoother and more deterministic temperature regulation, potentially due to the decrease in surface area to body weight ratio in the maturing infant. alpha was not associated with mean room temperature or influenced by immunization

Conclusions: This study shows that the quantification of long-range correlations using alpha derived from detrended fluctuation analysis is an observer-independent tool which can distinguish developmental stages of night time T(rec) pattern in young infants, reflective of maturation of the autonomic system. Detrended fluctuation analysis may prove useful for characterizing thermoregulation in premature and other infants at risk for life-threatening events.

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Night time Trec time series.a) Night time rectal temperature (Trec) recorded over 508 minute intervals from a single infant with a mean (SD) of 37.7°C (0.2). The corresponding random temperature (Tran) was generated by shuffling data points of Trec. b) Longitudinal night time rectal temperature traces Trec from the same infant as Figure 1a at 4, 8, and 12 weeks with mean and standard deviation of Trec and corresponding α shown.
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pone-0006431-g001: Night time Trec time series.a) Night time rectal temperature (Trec) recorded over 508 minute intervals from a single infant with a mean (SD) of 37.7°C (0.2). The corresponding random temperature (Tran) was generated by shuffling data points of Trec. b) Longitudinal night time rectal temperature traces Trec from the same infant as Figure 1a at 4, 8, and 12 weeks with mean and standard deviation of Trec and corresponding α shown.

Mentions: An example of a night time Trec recording as a function of time from a single subject and its randomized time series is shown in Figure 1a. The longitudinal night time Trec recordings from the same subject at 4, 8, and 12 weeks are shown in Figure 1b. A plot of the corresponding fluctuation function F(n) of the time-series in Figure 1a can be seen in Figure 2 on a log-log plot versus window size n. In 88 of the 95 datasets, F(n) had a linear trend up to window sizes of at least 180 minutes that could be characterized by the slope α of the linear regression with an r2>0.97 (Table 1). In 7 of 95 recordings the linear regression had an r2<0.97 and a smaller window range was chosen to fit a linear regression with r2>0.97. Overall mean (SD) of α for the 95 Trec night time time series was 1.51 (0.11). When the data were randomized, the average slope of the fluctuation function became 0.51, indicative of a random process. In our time series data we found no evidence of crossover phenomena implying that α did not change for different time scales (ie. window size, n) [25].


Long-range correlations in rectal temperature fluctuations of healthy infants during maturation.

Stern G, Beel J, Suki B, Silverman M, Westaway J, Cernelc M, Baldwin D, Frey U - PLoS ONE (2009)

Night time Trec time series.a) Night time rectal temperature (Trec) recorded over 508 minute intervals from a single infant with a mean (SD) of 37.7°C (0.2). The corresponding random temperature (Tran) was generated by shuffling data points of Trec. b) Longitudinal night time rectal temperature traces Trec from the same infant as Figure 1a at 4, 8, and 12 weeks with mean and standard deviation of Trec and corresponding α shown.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2713399&req=5

pone-0006431-g001: Night time Trec time series.a) Night time rectal temperature (Trec) recorded over 508 minute intervals from a single infant with a mean (SD) of 37.7°C (0.2). The corresponding random temperature (Tran) was generated by shuffling data points of Trec. b) Longitudinal night time rectal temperature traces Trec from the same infant as Figure 1a at 4, 8, and 12 weeks with mean and standard deviation of Trec and corresponding α shown.
Mentions: An example of a night time Trec recording as a function of time from a single subject and its randomized time series is shown in Figure 1a. The longitudinal night time Trec recordings from the same subject at 4, 8, and 12 weeks are shown in Figure 1b. A plot of the corresponding fluctuation function F(n) of the time-series in Figure 1a can be seen in Figure 2 on a log-log plot versus window size n. In 88 of the 95 datasets, F(n) had a linear trend up to window sizes of at least 180 minutes that could be characterized by the slope α of the linear regression with an r2>0.97 (Table 1). In 7 of 95 recordings the linear regression had an r2<0.97 and a smaller window range was chosen to fit a linear regression with r2>0.97. Overall mean (SD) of α for the 95 Trec night time time series was 1.51 (0.11). When the data were randomized, the average slope of the fluctuation function became 0.51, indicative of a random process. In our time series data we found no evidence of crossover phenomena implying that α did not change for different time scales (ie. window size, n) [25].

Bottom Line: We thus aimed to investigate the existence of fractal-like long-range correlations, indicative of temperature control, in night time rectal temperature (T(rec)) patterns in maturing infants.The effects of maturation, room temperature, and immunization on the strength of correlation were investigated.A significant increase in alpha with age from 1.42 (0.07) at 4 weeks to 1.58 (0.04) at 20 weeks reflects a change in long-range correlation behavior with maturation towards a smoother and more deterministic temperature regulation, potentially due to the decrease in surface area to body weight ratio in the maturing infant. alpha was not associated with mean room temperature or influenced by immunization This study shows that the quantification of long-range correlations using alpha derived from detrended fluctuation analysis is an observer-independent tool which can distinguish developmental stages of night time T(rec) pattern in young infants, reflective of maturation of the autonomic system.

View Article: PubMed Central - PubMed

Affiliation: Division of Respiratory Medicine, Department of Pediatrics, Inselspital and University of Bern, Bern, Switzerland. georgette.stern@insel.ch

ABSTRACT

Background: Control of breathing, heart rate, and body temperature are interdependent in infants, where instabilities in thermoregulation can contribute to apneas or even life-threatening events. Identifying abnormalities in thermoregulation is particularly important in the first 6 months of life, where autonomic regulation undergoes critical development. Fluctuations in body temperature have been shown to be sensitive to maturational stage as well as system failure in critically ill patients. We thus aimed to investigate the existence of fractal-like long-range correlations, indicative of temperature control, in night time rectal temperature (T(rec)) patterns in maturing infants.

Methodology/principal findings: We measured T(rec) fluctuations in infants every 4 weeks from 4 to 20 weeks of age and before and after immunization. Long-range correlations in the temperature series were quantified by the correlation exponent, alpha using detrended fluctuation analysis. The effects of maturation, room temperature, and immunization on the strength of correlation were investigated. We found that T(rec) fluctuations exhibit fractal long-range correlations with a mean (SD) alpha of 1.51 (0.11), indicating that T(rec) is regulated in a highly correlated and hence deterministic manner. A significant increase in alpha with age from 1.42 (0.07) at 4 weeks to 1.58 (0.04) at 20 weeks reflects a change in long-range correlation behavior with maturation towards a smoother and more deterministic temperature regulation, potentially due to the decrease in surface area to body weight ratio in the maturing infant. alpha was not associated with mean room temperature or influenced by immunization

Conclusions: This study shows that the quantification of long-range correlations using alpha derived from detrended fluctuation analysis is an observer-independent tool which can distinguish developmental stages of night time T(rec) pattern in young infants, reflective of maturation of the autonomic system. Detrended fluctuation analysis may prove useful for characterizing thermoregulation in premature and other infants at risk for life-threatening events.

Show MeSH
Related in: MedlinePlus