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Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia.

Anagnostopoulou KK, Kolovou GD, Kostakou PM, Mihas C, Hatzigeorgiou G, Marvaki C, Degiannis D, Mikhailidis DP, Cokkinos DV - Lipids Health Dis (2009)

Bottom Line: Furthermore, multivariate analysis revealed a gender association of TaqIB and I405V influence on postprandial lipaemia in this subgroup.Specifically, men carrying the B2 allele of the TaqIB polymorphism showed a higher postprandial triglyceride peak and a delayed return to basal values compared with women carrying B2.However, further investigations in larger populations are required to replicate and confirm these findings.

View Article: PubMed Central - HTML - PubMed

Affiliation: 1st Cardiology Department, Onassis Cardiac Surgery Center Athens, Greece. kat_anag@yahoo.com

ABSTRACT

Background: This study assessed the gender-specific influence of the cholesteryl ester transfer protein (TaqIB, I405V) and lipoprotein lipase (S447X) polymorphisms on the response to an oral fat tolerance test in heterozygotes for familial hypercholesterolaemia.

Methods: We selected and genotyped 80 men and postmenopausal women heterozygous for familial hypercholesterolaemia (main group) as well as 11 healthy control subjects. Patients were subgrouped based on their response to oral fat tolerance test. The oral fat tolerance test was defined as pathological when postprandial triglyceride concentration was higher than the highest triglyceride concentration observed in healthy subjects (220 mg/dl) at any time (2, 4, 6 or 8 h).

Results: In the pathological subgroup, men had significantly higher incremental area under the curve after oral fat tolerance test than postmenopausal women. Furthermore, multivariate analysis revealed a gender association of TaqIB and I405V influence on postprandial lipaemia in this subgroup.

Conclusion: In conclusion, it seems that gender and TaqIB polymorphism of the cholesteryl ester transfer protein gene were both associated with the distribution of triglyceride values after oral fat tolerance test, only in subjects with a pathological response to oral fat tolerance test. Specifically, men carrying the B2 allele of the TaqIB polymorphism showed a higher postprandial triglyceride peak and a delayed return to basal values compared with women carrying B2. However, further investigations in larger populations are required to replicate and confirm these findings.

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Lipid values in hFH-P men and women with the I or V alleles. Number of I and V alleles in men are 33 and 15, and in women are 28 and 14, respectively.
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Figure 3: Lipid values in hFH-P men and women with the I or V alleles. Number of I and V alleles in men are 33 and 15, and in women are 28 and 14, respectively.

Mentions: There wasn't any association between with B1, B2 (TaqIB), I, V (I405V) and S, X (S447X) carriers and OFTT response influenced by gender in the main group. Concerning the subgroup hFH-P, women carrying the B2 (TaqIB) allele had higher TC levels (317 ± 36 vs. 295 ± 53 mg/dl, p = 0.05) lower TG levels at the 4th hour (239 ± 65 vs. 279 ± 95 mg/dl, p = 0.03) after fat load, compared with men with the B2 allele (fig 1 and fig 2). No other differences between men and women were observed. Women carrying either the B1 or B2 allele had higher HDL cholesterol (45 ± 14 vs. 36 ± 10 mg/dl, p < 0.01, 58 ± 12 vs. 39 ± 5 mg/dl, p < 0.01) and higher apolipoprotein AI levels (157 ± 41 vs. 125 ± 27 mg/dl, p < 0.01, 173 ± 27 vs. 130 ± 22 mg/dl, p < 0.01) compared with men carrying either the B1 or B2 allele, respectively (fig 1). Women with the I (I405V) allele had lower TC levels (315 ± 40 vs. 305 ± 69 mg/dl, p = 0.04) compared with men carrying the I allele (fig 3). Regarding the rest of lipid parameters, women carrying either the I or V allele had higher HDL cholesterol (56 ± 20 vs. 38 ± 8 mg/dl, p < 0.01, 53 ± 22 vs. 36 ± 7 mg/dl, p = 0.01), higher apolipoprotein AI (158 ± 26 vs. 130 ± 23 mg/dl, p < 0.01, 169 ± 47 vs. 120 ± 23 mg/dl, p = 0.01), and lower incremental TG-AUC (743 ± 363 vs. 934 ± 361 mg/dl, p = 0.04, 646 ± 285 vs. 844 ± 427 mg/dl, p = 0.05), compared with men carrying either the I or V allele, respectively (fig 3). No association of the S447X polymorphism with gender and OFTT was found.


Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia.

Anagnostopoulou KK, Kolovou GD, Kostakou PM, Mihas C, Hatzigeorgiou G, Marvaki C, Degiannis D, Mikhailidis DP, Cokkinos DV - Lipids Health Dis (2009)

Lipid values in hFH-P men and women with the I or V alleles. Number of I and V alleles in men are 33 and 15, and in women are 28 and 14, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2713233&req=5

Figure 3: Lipid values in hFH-P men and women with the I or V alleles. Number of I and V alleles in men are 33 and 15, and in women are 28 and 14, respectively.
Mentions: There wasn't any association between with B1, B2 (TaqIB), I, V (I405V) and S, X (S447X) carriers and OFTT response influenced by gender in the main group. Concerning the subgroup hFH-P, women carrying the B2 (TaqIB) allele had higher TC levels (317 ± 36 vs. 295 ± 53 mg/dl, p = 0.05) lower TG levels at the 4th hour (239 ± 65 vs. 279 ± 95 mg/dl, p = 0.03) after fat load, compared with men with the B2 allele (fig 1 and fig 2). No other differences between men and women were observed. Women carrying either the B1 or B2 allele had higher HDL cholesterol (45 ± 14 vs. 36 ± 10 mg/dl, p < 0.01, 58 ± 12 vs. 39 ± 5 mg/dl, p < 0.01) and higher apolipoprotein AI levels (157 ± 41 vs. 125 ± 27 mg/dl, p < 0.01, 173 ± 27 vs. 130 ± 22 mg/dl, p < 0.01) compared with men carrying either the B1 or B2 allele, respectively (fig 1). Women with the I (I405V) allele had lower TC levels (315 ± 40 vs. 305 ± 69 mg/dl, p = 0.04) compared with men carrying the I allele (fig 3). Regarding the rest of lipid parameters, women carrying either the I or V allele had higher HDL cholesterol (56 ± 20 vs. 38 ± 8 mg/dl, p < 0.01, 53 ± 22 vs. 36 ± 7 mg/dl, p = 0.01), higher apolipoprotein AI (158 ± 26 vs. 130 ± 23 mg/dl, p < 0.01, 169 ± 47 vs. 120 ± 23 mg/dl, p = 0.01), and lower incremental TG-AUC (743 ± 363 vs. 934 ± 361 mg/dl, p = 0.04, 646 ± 285 vs. 844 ± 427 mg/dl, p = 0.05), compared with men carrying either the I or V allele, respectively (fig 3). No association of the S447X polymorphism with gender and OFTT was found.

Bottom Line: Furthermore, multivariate analysis revealed a gender association of TaqIB and I405V influence on postprandial lipaemia in this subgroup.Specifically, men carrying the B2 allele of the TaqIB polymorphism showed a higher postprandial triglyceride peak and a delayed return to basal values compared with women carrying B2.However, further investigations in larger populations are required to replicate and confirm these findings.

View Article: PubMed Central - HTML - PubMed

Affiliation: 1st Cardiology Department, Onassis Cardiac Surgery Center Athens, Greece. kat_anag@yahoo.com

ABSTRACT

Background: This study assessed the gender-specific influence of the cholesteryl ester transfer protein (TaqIB, I405V) and lipoprotein lipase (S447X) polymorphisms on the response to an oral fat tolerance test in heterozygotes for familial hypercholesterolaemia.

Methods: We selected and genotyped 80 men and postmenopausal women heterozygous for familial hypercholesterolaemia (main group) as well as 11 healthy control subjects. Patients were subgrouped based on their response to oral fat tolerance test. The oral fat tolerance test was defined as pathological when postprandial triglyceride concentration was higher than the highest triglyceride concentration observed in healthy subjects (220 mg/dl) at any time (2, 4, 6 or 8 h).

Results: In the pathological subgroup, men had significantly higher incremental area under the curve after oral fat tolerance test than postmenopausal women. Furthermore, multivariate analysis revealed a gender association of TaqIB and I405V influence on postprandial lipaemia in this subgroup.

Conclusion: In conclusion, it seems that gender and TaqIB polymorphism of the cholesteryl ester transfer protein gene were both associated with the distribution of triglyceride values after oral fat tolerance test, only in subjects with a pathological response to oral fat tolerance test. Specifically, men carrying the B2 allele of the TaqIB polymorphism showed a higher postprandial triglyceride peak and a delayed return to basal values compared with women carrying B2. However, further investigations in larger populations are required to replicate and confirm these findings.

Show MeSH
Related in: MedlinePlus