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Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases.

Suzuki J, Isobe M, Morishita R, Nagai R - Mediators Inflamm. (2009)

Bottom Line: Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects.These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB).From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.

View Article: PubMed Central - PubMed

Affiliation: Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan. junichisuzuki-circ@umin.ac.jp

ABSTRACT
Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.

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Immunohistochemistry of atherosclerosis. Panels show representative immunohistochemical findings.  VCAM-1 expression was enhanced in the aortic walls of non-treated LDLRKO mice.  However, catechin administration (2% THEA-FLAN 90S contained high fat chaw) suppressed the expression in the organs of LDLRKO mice.
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fig4: Immunohistochemistry of atherosclerosis. Panels show representative immunohistochemical findings. VCAM-1 expression was enhanced in the aortic walls of non-treated LDLRKO mice. However, catechin administration (2% THEA-FLAN 90S contained high fat chaw) suppressed the expression in the organs of LDLRKO mice.

Mentions: To evaluate the effects of tea catechins for the development of atherosclerosis induced by hyperlipidemia, we administered catechins (2 or 4% THEA-FLAN 90S contained high fat chaw) to LDL receptor knockout (LDLRKO) mice. Immunohistocemically, VCAM-1, a critical adhesion molecule for vascular diseases, expression was enhanced in the endothelial cells, smooth muscle cells, and infiltrating cells in the aortic walls of LDLRKO mice. However, catechin administration significantly suppressed VCAM-1 expression in the atherosclerotic lesions in LDLRKO mice, although LDLRKO mice with the 2% catechins showed comparable cholesterol levels (Figure 4) [15]. In the study, catechins prevent the development with or without changing the plasma lipid levels in the animals through the suppression of adhesion molecules. Babu and Lie reviewed that catechins have further effects on cell adhesion molecules. They showed that catechins prevent vascular inflammation via suppression of leukocyte adhesion to endothelium and subsequent transmigration through inhibition of transcriptional factor NF-κB-mediated production of adhesion molecules both in endothelial cells and inflammatory cells [41].


Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases.

Suzuki J, Isobe M, Morishita R, Nagai R - Mediators Inflamm. (2009)

Immunohistochemistry of atherosclerosis. Panels show representative immunohistochemical findings.  VCAM-1 expression was enhanced in the aortic walls of non-treated LDLRKO mice.  However, catechin administration (2% THEA-FLAN 90S contained high fat chaw) suppressed the expression in the organs of LDLRKO mice.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2712737&req=5

fig4: Immunohistochemistry of atherosclerosis. Panels show representative immunohistochemical findings. VCAM-1 expression was enhanced in the aortic walls of non-treated LDLRKO mice. However, catechin administration (2% THEA-FLAN 90S contained high fat chaw) suppressed the expression in the organs of LDLRKO mice.
Mentions: To evaluate the effects of tea catechins for the development of atherosclerosis induced by hyperlipidemia, we administered catechins (2 or 4% THEA-FLAN 90S contained high fat chaw) to LDL receptor knockout (LDLRKO) mice. Immunohistocemically, VCAM-1, a critical adhesion molecule for vascular diseases, expression was enhanced in the endothelial cells, smooth muscle cells, and infiltrating cells in the aortic walls of LDLRKO mice. However, catechin administration significantly suppressed VCAM-1 expression in the atherosclerotic lesions in LDLRKO mice, although LDLRKO mice with the 2% catechins showed comparable cholesterol levels (Figure 4) [15]. In the study, catechins prevent the development with or without changing the plasma lipid levels in the animals through the suppression of adhesion molecules. Babu and Lie reviewed that catechins have further effects on cell adhesion molecules. They showed that catechins prevent vascular inflammation via suppression of leukocyte adhesion to endothelium and subsequent transmigration through inhibition of transcriptional factor NF-κB-mediated production of adhesion molecules both in endothelial cells and inflammatory cells [41].

Bottom Line: Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects.These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB).From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.

View Article: PubMed Central - PubMed

Affiliation: Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan. junichisuzuki-circ@umin.ac.jp

ABSTRACT
Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.

Show MeSH
Related in: MedlinePlus