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Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases.

Suzuki J, Isobe M, Morishita R, Nagai R - Mediators Inflamm. (2009)

Bottom Line: Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects.These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB).From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.

View Article: PubMed Central - PubMed

Affiliation: Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan. junichisuzuki-circ@umin.ac.jp

ABSTRACT
Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.

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Related in: MedlinePlus

RNase protection assay of myocarditis. TNF-alpha mRNA level was markedly decreased in the catechin treated group compared with that of control group.  On the other hand, mRNA levels of Th2 cytokines such as IL-4 and IL-10 in the catechin treated group (20 mg/kg/day, THEA-FLAN 90S) were markedly enhanced compared with that of control group.
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fig3: RNase protection assay of myocarditis. TNF-alpha mRNA level was markedly decreased in the catechin treated group compared with that of control group. On the other hand, mRNA levels of Th2 cytokines such as IL-4 and IL-10 in the catechin treated group (20 mg/kg/day, THEA-FLAN 90S) were markedly enhanced compared with that of control group.

Mentions: Myocarditis is a serious disease in clinical settings, patients with myocarditis may present with rapidly progressive heart failure, shock, or arrhythmia. Although acute myocardial inflammation is an essential etiology for the progression, any established treatment has not yet been elucidated [31–35]. Experimental autoimmune myocarditis (EAMs) is a rat model that is characterized by myocardial damages and multinucleated giant cell infiltration. This has been used as a disease model of human acute myocarditis [36–40]. To clarify the effects of catechins on myocarditis, we administered the catechins (20 mg/kg/day, THEA-FLAN 90S) to rats after the induction of EAM. We found that the catechins significantly reduced the heart weight/body weight ratio compared to that of non-treated EAM controls. Echocardiogram revealed the catechins improved the cardiac function compared to the controls. Pathologically, non-treated control EAM animals showed severe myocardial cell infiltration and fibrotic lesions. However, the catechin treatment showed significantly less myocardial cell infiltration and fibrosis areas compared to those in controls. Immunohistochemistry revealed that enhanced expression of CD4, CD8, CD11b, ICAM-1, and NF-κB on infiltrating and arterial endothelial cells was observed in non-treated EAM hearts, while the catechins suppressed the expression. To examine expression of cytokine mRNA in EAM hearts, RNase protection assay was used. TNF-alpha mRNA level was markedly decreased in the catechin-treated group compared with that of control group. On the other hand, mRNA levels of Th2 cytokines such as IL-4 and IL-10 in the catechin-treated group were markedly enhanced compared with that of control group (Figure 3). We revealed that the myocardial cell infiltration, fibrosis, proinflammatory cytokines were enhanced in the EAM progression and the catechins suppressed the development of these changes with altered cytokine expression [13].


Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases.

Suzuki J, Isobe M, Morishita R, Nagai R - Mediators Inflamm. (2009)

RNase protection assay of myocarditis. TNF-alpha mRNA level was markedly decreased in the catechin treated group compared with that of control group.  On the other hand, mRNA levels of Th2 cytokines such as IL-4 and IL-10 in the catechin treated group (20 mg/kg/day, THEA-FLAN 90S) were markedly enhanced compared with that of control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2712737&req=5

fig3: RNase protection assay of myocarditis. TNF-alpha mRNA level was markedly decreased in the catechin treated group compared with that of control group. On the other hand, mRNA levels of Th2 cytokines such as IL-4 and IL-10 in the catechin treated group (20 mg/kg/day, THEA-FLAN 90S) were markedly enhanced compared with that of control group.
Mentions: Myocarditis is a serious disease in clinical settings, patients with myocarditis may present with rapidly progressive heart failure, shock, or arrhythmia. Although acute myocardial inflammation is an essential etiology for the progression, any established treatment has not yet been elucidated [31–35]. Experimental autoimmune myocarditis (EAMs) is a rat model that is characterized by myocardial damages and multinucleated giant cell infiltration. This has been used as a disease model of human acute myocarditis [36–40]. To clarify the effects of catechins on myocarditis, we administered the catechins (20 mg/kg/day, THEA-FLAN 90S) to rats after the induction of EAM. We found that the catechins significantly reduced the heart weight/body weight ratio compared to that of non-treated EAM controls. Echocardiogram revealed the catechins improved the cardiac function compared to the controls. Pathologically, non-treated control EAM animals showed severe myocardial cell infiltration and fibrotic lesions. However, the catechin treatment showed significantly less myocardial cell infiltration and fibrosis areas compared to those in controls. Immunohistochemistry revealed that enhanced expression of CD4, CD8, CD11b, ICAM-1, and NF-κB on infiltrating and arterial endothelial cells was observed in non-treated EAM hearts, while the catechins suppressed the expression. To examine expression of cytokine mRNA in EAM hearts, RNase protection assay was used. TNF-alpha mRNA level was markedly decreased in the catechin-treated group compared with that of control group. On the other hand, mRNA levels of Th2 cytokines such as IL-4 and IL-10 in the catechin-treated group were markedly enhanced compared with that of control group (Figure 3). We revealed that the myocardial cell infiltration, fibrosis, proinflammatory cytokines were enhanced in the EAM progression and the catechins suppressed the development of these changes with altered cytokine expression [13].

Bottom Line: Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects.These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB).From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.

View Article: PubMed Central - PubMed

Affiliation: Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan. junichisuzuki-circ@umin.ac.jp

ABSTRACT
Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.

Show MeSH
Related in: MedlinePlus