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Schwannoma of the eyelid: apropos of two cases.

Touzri RA, Errais K, Zermani R, Benjilani S, Ouertani A - Indian J Ophthalmol (2009 Jul-Aug)

Bottom Line: Schwannoma of ophthalmic interest is rare although it has been reported in relation with the orbit, and less frequently with the uveal tract and conjunctiva.Up until now, only eight cases have been reported in literature.Herein, we report two cases of eyelid schwannoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Charles Nicolle University Hospital, Tunis, Tunisia. fr.touzri@gnet.tn

ABSTRACT
Schwannoma, also referred to as neurilemmoma, is a benign tumor of peripheral nerve arising from Schwann cells that form the neural sheath. Schwannoma of ophthalmic interest is rare although it has been reported in relation with the orbit, and less frequently with the uveal tract and conjunctiva. Isolated eyelid schwannoma is extremely uncommon. Up until now, only eight cases have been reported in literature. Herein, we report two cases of eyelid schwannoma.

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Histopathology of Case 1: admixture of compactly arranged interlacing fascicles, Antoni A pattern (black arrow), and loosely arranged cells separated by clear matrix, Antoni B pattern (white arrow) (H and E, ×25)
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Figure 0001: Histopathology of Case 1: admixture of compactly arranged interlacing fascicles, Antoni A pattern (black arrow), and loosely arranged cells separated by clear matrix, Antoni B pattern (white arrow) (H and E, ×25)

Mentions: Pathological studies showed an encapsulated spheric mass (6mm in diameter) on macroscopic examination. Microscopic examination revealed a biphasic pattern, with highly cellular areas of non-pigmented spindle cells, containing elongated nuclei arranged in fascicles, which were separated by homogenous acellular material (Antoni A pattern). In other areas, the cells were more oval, and had rounded nuclei, clear cytoplasm and less basement membrane, and were loosely entwined within a clear myxoid matrix (Antoni B pattern) [Fig. 1]. No histopathologic features of malignancy were present. Immunochemistry for S-100 protein was strongly positive, but tumor cells did not react with HMB45. The final diagnosis was benign schwannoma Type A and B of the eyelid.


Schwannoma of the eyelid: apropos of two cases.

Touzri RA, Errais K, Zermani R, Benjilani S, Ouertani A - Indian J Ophthalmol (2009 Jul-Aug)

Histopathology of Case 1: admixture of compactly arranged interlacing fascicles, Antoni A pattern (black arrow), and loosely arranged cells separated by clear matrix, Antoni B pattern (white arrow) (H and E, ×25)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2712707&req=5

Figure 0001: Histopathology of Case 1: admixture of compactly arranged interlacing fascicles, Antoni A pattern (black arrow), and loosely arranged cells separated by clear matrix, Antoni B pattern (white arrow) (H and E, ×25)
Mentions: Pathological studies showed an encapsulated spheric mass (6mm in diameter) on macroscopic examination. Microscopic examination revealed a biphasic pattern, with highly cellular areas of non-pigmented spindle cells, containing elongated nuclei arranged in fascicles, which were separated by homogenous acellular material (Antoni A pattern). In other areas, the cells were more oval, and had rounded nuclei, clear cytoplasm and less basement membrane, and were loosely entwined within a clear myxoid matrix (Antoni B pattern) [Fig. 1]. No histopathologic features of malignancy were present. Immunochemistry for S-100 protein was strongly positive, but tumor cells did not react with HMB45. The final diagnosis was benign schwannoma Type A and B of the eyelid.

Bottom Line: Schwannoma of ophthalmic interest is rare although it has been reported in relation with the orbit, and less frequently with the uveal tract and conjunctiva.Up until now, only eight cases have been reported in literature.Herein, we report two cases of eyelid schwannoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Charles Nicolle University Hospital, Tunis, Tunisia. fr.touzri@gnet.tn

ABSTRACT
Schwannoma, also referred to as neurilemmoma, is a benign tumor of peripheral nerve arising from Schwann cells that form the neural sheath. Schwannoma of ophthalmic interest is rare although it has been reported in relation with the orbit, and less frequently with the uveal tract and conjunctiva. Isolated eyelid schwannoma is extremely uncommon. Up until now, only eight cases have been reported in literature. Herein, we report two cases of eyelid schwannoma.

Show MeSH
Related in: MedlinePlus