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Vision recovery in human immunodeficiency virus-infected patients with optic neuropathy treated with highly active antiretroviral therapy: a case series.

Babu K, Murthy KR, Rajagopalan N, Satish B - Indian J Ophthalmol (2009 Jul-Aug)

Bottom Line: The above diagnosis was made by exclusion of infectious agents and neoplasms by detailed clinical and laboratory investigations.All patients had decreased visual acuity, pale optic discs and constriction of visual fields.Optic neuropathy in HIV-positive patients does not necessarily carry a poor prognosis even when a treatable cause is not found.

View Article: PubMed Central - PubMed

Affiliation: Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Center, 504 40th Cross, Jayanagar, Bangalore, India. kb_7375@yahoo.co.in

ABSTRACT
We describe three patients with bilateral, presumed human immunodeficiency virus (HIV)-induced optic neuropathy. The above diagnosis was made by exclusion of infectious agents and neoplasms by detailed clinical and laboratory investigations. All patients had decreased visual acuity, pale optic discs and constriction of visual fields. Improvement was documented in all three patients for visual acuity and in one patient for visual fields following treatment with highly active antiretroviral therapy (HAART). Optic neuropathy in HIV-positive patients does not necessarily carry a poor prognosis even when a treatable cause is not found. This article emphasizes the effectiveness of HAART in presumed HIV-induced optic neuropathy.

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Related in: MedlinePlus

Photograph of the visual fields of the right eye of case 2 showing gross constriction of visual fields, HVF 30-2
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Figure 0003: Photograph of the visual fields of the right eye of case 2 showing gross constriction of visual fields, HVF 30-2

Mentions: A 13-year-old retrovirus positive girl was referred to us for a routine ophthalmic evaluation. At the time of examination, she was unaware of the poor vision in the left eye. Her BCVA was 20/30 and counting fingers close to the face in the right eye and the left eye, respectively. Relative afferent pupillary defect was noted in the left eye. CD4 counts were 287 cells × 106/L. Mild optic disc pallor in the right eye and pale optic disc in the left eye was noted [Figs. 2a and b]. Visual fields (HVF 30-2) in the right eye showed gross constriction [Figures 3a and b]. After starting HAART, her BCVA at 20 months follow-up is 20/20 in the right eye and counting finger at 3 meters in the left eye. Serial visual fields also showed improvement in the right eye [Figures 4a and b]. The CD4 count at this follow-up was 662 cells × 106/L.


Vision recovery in human immunodeficiency virus-infected patients with optic neuropathy treated with highly active antiretroviral therapy: a case series.

Babu K, Murthy KR, Rajagopalan N, Satish B - Indian J Ophthalmol (2009 Jul-Aug)

Photograph of the visual fields of the right eye of case 2 showing gross constriction of visual fields, HVF 30-2
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2712706&req=5

Figure 0003: Photograph of the visual fields of the right eye of case 2 showing gross constriction of visual fields, HVF 30-2
Mentions: A 13-year-old retrovirus positive girl was referred to us for a routine ophthalmic evaluation. At the time of examination, she was unaware of the poor vision in the left eye. Her BCVA was 20/30 and counting fingers close to the face in the right eye and the left eye, respectively. Relative afferent pupillary defect was noted in the left eye. CD4 counts were 287 cells × 106/L. Mild optic disc pallor in the right eye and pale optic disc in the left eye was noted [Figs. 2a and b]. Visual fields (HVF 30-2) in the right eye showed gross constriction [Figures 3a and b]. After starting HAART, her BCVA at 20 months follow-up is 20/20 in the right eye and counting finger at 3 meters in the left eye. Serial visual fields also showed improvement in the right eye [Figures 4a and b]. The CD4 count at this follow-up was 662 cells × 106/L.

Bottom Line: The above diagnosis was made by exclusion of infectious agents and neoplasms by detailed clinical and laboratory investigations.All patients had decreased visual acuity, pale optic discs and constriction of visual fields.Optic neuropathy in HIV-positive patients does not necessarily carry a poor prognosis even when a treatable cause is not found.

View Article: PubMed Central - PubMed

Affiliation: Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Center, 504 40th Cross, Jayanagar, Bangalore, India. kb_7375@yahoo.co.in

ABSTRACT
We describe three patients with bilateral, presumed human immunodeficiency virus (HIV)-induced optic neuropathy. The above diagnosis was made by exclusion of infectious agents and neoplasms by detailed clinical and laboratory investigations. All patients had decreased visual acuity, pale optic discs and constriction of visual fields. Improvement was documented in all three patients for visual acuity and in one patient for visual fields following treatment with highly active antiretroviral therapy (HAART). Optic neuropathy in HIV-positive patients does not necessarily carry a poor prognosis even when a treatable cause is not found. This article emphasizes the effectiveness of HAART in presumed HIV-induced optic neuropathy.

Show MeSH
Related in: MedlinePlus