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The effects of overfeeding on the neuronal response to visual food cues in thin and reduced-obese individuals.

Cornier MA, Salzberg AK, Endly DC, Bessesen DH, Rojas DC, Tregellas JR - PLoS ONE (2009)

Bottom Line: The objective of this study was to examine the effects of short-term overfeeding on the neuronal response to food-related visual stimuli in individuals prone and resistant to weight gain. 22 thin and 19 reduced-obese (RO) individuals were studied.In the eucaloric state, food as compared to non-food images elicited significantly greater activation of insula and inferior visual cortex in thin as compared to RO individuals.Two days of overfeeding led to significant attenuation of not only insula and visual cortex responses but also of hypothalamus response in thin as compared to RO individuals.

View Article: PubMed Central - PubMed

Affiliation: Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America. marc.cornier@ucdenver.edu

ABSTRACT

Background: The regulation of energy intake is a complex process involving the integration of homeostatic signals and both internal and external sensory inputs. The objective of this study was to examine the effects of short-term overfeeding on the neuronal response to food-related visual stimuli in individuals prone and resistant to weight gain.

Methodology/principal findings: 22 thin and 19 reduced-obese (RO) individuals were studied. Functional magnetic resonance imaging (fMRI) was performed in the fasted state after two days of eucaloric energy intake and after two days of 30% overfeeding in a counterbalanced design. fMRI was performed while subjects viewed images of foods of high hedonic value and neutral non-food objects. In the eucaloric state, food as compared to non-food images elicited significantly greater activation of insula and inferior visual cortex in thin as compared to RO individuals. Two days of overfeeding led to significant attenuation of not only insula and visual cortex responses but also of hypothalamus response in thin as compared to RO individuals.

Conclusions/significance: These findings emphasize the important role of food-related visual cues in ingestive behavior and suggest that there are important phenotypic differences in the interactions between external visual sensory inputs, energy balance status, and brain regions involved in the regulation of energy intake. Furthermore, alterations in the neuronal response to food cues may relate to the propensity to gain weight.

Show MeSH
Neuronal response in thin as compared to reduced-obese individuals.The difference in neuronal response in thin as compared to reduced-obese individuals to foods of high hedonic value in the eucaloric state is shown (EU:Thin>RO:H>O). Greater activation of the insula and visual cortex is noted in thin as compared to reduced-obese individuals. Statistical maps thresholded at p<0.01 for visualization and overlaid onto the group average anatomical image. Data are shown in the radiological convention (right hemisphere on the left).
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pone-0006310-g002: Neuronal response in thin as compared to reduced-obese individuals.The difference in neuronal response in thin as compared to reduced-obese individuals to foods of high hedonic value in the eucaloric state is shown (EU:Thin>RO:H>O). Greater activation of the insula and visual cortex is noted in thin as compared to reduced-obese individuals. Statistical maps thresholded at p<0.01 for visualization and overlaid onto the group average anatomical image. Data are shown in the radiological convention (right hemisphere on the left).

Mentions: Next, we turn our attention to the RO cohort and how their responses differ from the thin individuals. In the eucaloric state, as shown in Figure 2, thin individuals had greater activation of inferior visual cortex (t(1,75) = 3.36, p = 0.044, right;) and a trend for greater activation of the insula (t(1,75) = 2.78, p = 0.097, left) compared to RO individuals (EU:Thin>RO:H>O). No brain regions were more activated in RO as compared to thin individuals in the eucaloric state (EU:RO>Thin:H>O).


The effects of overfeeding on the neuronal response to visual food cues in thin and reduced-obese individuals.

Cornier MA, Salzberg AK, Endly DC, Bessesen DH, Rojas DC, Tregellas JR - PLoS ONE (2009)

Neuronal response in thin as compared to reduced-obese individuals.The difference in neuronal response in thin as compared to reduced-obese individuals to foods of high hedonic value in the eucaloric state is shown (EU:Thin>RO:H>O). Greater activation of the insula and visual cortex is noted in thin as compared to reduced-obese individuals. Statistical maps thresholded at p<0.01 for visualization and overlaid onto the group average anatomical image. Data are shown in the radiological convention (right hemisphere on the left).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2712682&req=5

pone-0006310-g002: Neuronal response in thin as compared to reduced-obese individuals.The difference in neuronal response in thin as compared to reduced-obese individuals to foods of high hedonic value in the eucaloric state is shown (EU:Thin>RO:H>O). Greater activation of the insula and visual cortex is noted in thin as compared to reduced-obese individuals. Statistical maps thresholded at p<0.01 for visualization and overlaid onto the group average anatomical image. Data are shown in the radiological convention (right hemisphere on the left).
Mentions: Next, we turn our attention to the RO cohort and how their responses differ from the thin individuals. In the eucaloric state, as shown in Figure 2, thin individuals had greater activation of inferior visual cortex (t(1,75) = 3.36, p = 0.044, right;) and a trend for greater activation of the insula (t(1,75) = 2.78, p = 0.097, left) compared to RO individuals (EU:Thin>RO:H>O). No brain regions were more activated in RO as compared to thin individuals in the eucaloric state (EU:RO>Thin:H>O).

Bottom Line: The objective of this study was to examine the effects of short-term overfeeding on the neuronal response to food-related visual stimuli in individuals prone and resistant to weight gain. 22 thin and 19 reduced-obese (RO) individuals were studied.In the eucaloric state, food as compared to non-food images elicited significantly greater activation of insula and inferior visual cortex in thin as compared to RO individuals.Two days of overfeeding led to significant attenuation of not only insula and visual cortex responses but also of hypothalamus response in thin as compared to RO individuals.

View Article: PubMed Central - PubMed

Affiliation: Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America. marc.cornier@ucdenver.edu

ABSTRACT

Background: The regulation of energy intake is a complex process involving the integration of homeostatic signals and both internal and external sensory inputs. The objective of this study was to examine the effects of short-term overfeeding on the neuronal response to food-related visual stimuli in individuals prone and resistant to weight gain.

Methodology/principal findings: 22 thin and 19 reduced-obese (RO) individuals were studied. Functional magnetic resonance imaging (fMRI) was performed in the fasted state after two days of eucaloric energy intake and after two days of 30% overfeeding in a counterbalanced design. fMRI was performed while subjects viewed images of foods of high hedonic value and neutral non-food objects. In the eucaloric state, food as compared to non-food images elicited significantly greater activation of insula and inferior visual cortex in thin as compared to RO individuals. Two days of overfeeding led to significant attenuation of not only insula and visual cortex responses but also of hypothalamus response in thin as compared to RO individuals.

Conclusions/significance: These findings emphasize the important role of food-related visual cues in ingestive behavior and suggest that there are important phenotypic differences in the interactions between external visual sensory inputs, energy balance status, and brain regions involved in the regulation of energy intake. Furthermore, alterations in the neuronal response to food cues may relate to the propensity to gain weight.

Show MeSH