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Acromegaly and gigantism in the medical literature. Case descriptions in the era before and the early years after the initial publication of Pierre Marie (1886).

de Herder WW - Pituitary (2009)

Bottom Line: Pituitary adenomas could be found in the great majority of cases.It also became clear that acromegaly and gigantism were the same disease but occurring at different stages of life and not different diseases as initially thought.The stage was set for further research into the pathogenesis, diagnosis and therapy of acromegaly and gigantism.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, 3015 CE Rotterdam, The Netherlands. w.w.deherder@erasmusmc.nl

ABSTRACT
In 1886 Pierre Marie used the term "acromegaly" for the first time and gave a full description of the characteristic clinical picture. However several others had already given clear clinical descriptions before him and sometimes had given the disease other names. After 1886, it gradually became clear that pituitary enlargement (caused by a pituitary adenoma) was the cause and not the consequence of acromegaly, as initially thought. Pituitary adenomas could be found in the great majority of cases. It also became clear that acromegaly and gigantism were the same disease but occurring at different stages of life and not different diseases as initially thought. At the end of the 19th and beginning of the 20th century most information was derived from case descriptions and post-mortem examinations of patients with acromegaly or (famous) patients with gigantism. The stage was set for further research into the pathogenesis, diagnosis and therapy of acromegaly and gigantism.

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Jacob Ehrlich (Jack Earle) (1906, Denver (Colorado, USA)—1952 El Paso (Texas, USA)). Collection W.W. de Herder
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Fig7: Jacob Ehrlich (Jack Earle) (1906, Denver (Colorado, USA)—1952 El Paso (Texas, USA)). Collection W.W. de Herder

Mentions: Jacob Ehrlich (Jack Earle) (1906, Denver (Colorado, USA)—1952 El Paso (Texas, USA)) developed normally until the age of 8. From then on he grew rapidly until the age of 16 (Fig. 7). His final height was 2.32 m. (7 ft 7.5 in), although he claimed to be 2.59–2.62 m. (8 ft 6–7 in). He grew up in El Paso, Texas where he also finished high school, and obtained his nicknames: “Pecos Bill”, “The Texas Giant”, “The El Paso Giant”, and “Texas Jack”. He worked in the movie business, painted, and sculpted. He was a prize-winning photographer and a poet (he published a book of poetry called: “The Long Shadows”).Fig. 7


Acromegaly and gigantism in the medical literature. Case descriptions in the era before and the early years after the initial publication of Pierre Marie (1886).

de Herder WW - Pituitary (2009)

Jacob Ehrlich (Jack Earle) (1906, Denver (Colorado, USA)—1952 El Paso (Texas, USA)). Collection W.W. de Herder
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2712620&req=5

Fig7: Jacob Ehrlich (Jack Earle) (1906, Denver (Colorado, USA)—1952 El Paso (Texas, USA)). Collection W.W. de Herder
Mentions: Jacob Ehrlich (Jack Earle) (1906, Denver (Colorado, USA)—1952 El Paso (Texas, USA)) developed normally until the age of 8. From then on he grew rapidly until the age of 16 (Fig. 7). His final height was 2.32 m. (7 ft 7.5 in), although he claimed to be 2.59–2.62 m. (8 ft 6–7 in). He grew up in El Paso, Texas where he also finished high school, and obtained his nicknames: “Pecos Bill”, “The Texas Giant”, “The El Paso Giant”, and “Texas Jack”. He worked in the movie business, painted, and sculpted. He was a prize-winning photographer and a poet (he published a book of poetry called: “The Long Shadows”).Fig. 7

Bottom Line: Pituitary adenomas could be found in the great majority of cases.It also became clear that acromegaly and gigantism were the same disease but occurring at different stages of life and not different diseases as initially thought.The stage was set for further research into the pathogenesis, diagnosis and therapy of acromegaly and gigantism.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, 3015 CE Rotterdam, The Netherlands. w.w.deherder@erasmusmc.nl

ABSTRACT
In 1886 Pierre Marie used the term "acromegaly" for the first time and gave a full description of the characteristic clinical picture. However several others had already given clear clinical descriptions before him and sometimes had given the disease other names. After 1886, it gradually became clear that pituitary enlargement (caused by a pituitary adenoma) was the cause and not the consequence of acromegaly, as initially thought. Pituitary adenomas could be found in the great majority of cases. It also became clear that acromegaly and gigantism were the same disease but occurring at different stages of life and not different diseases as initially thought. At the end of the 19th and beginning of the 20th century most information was derived from case descriptions and post-mortem examinations of patients with acromegaly or (famous) patients with gigantism. The stage was set for further research into the pathogenesis, diagnosis and therapy of acromegaly and gigantism.

Show MeSH
Related in: MedlinePlus