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A systematic review of health-related quality of life in cutaneous melanoma.

Cornish D, Holterhues C, van de Poll-Franse LV, Coebergh JW, Nijsten T - Ann. Oncol. (2009)

Bottom Line: Of the 158 abstracts, 44 articles were appraised, resulting in 13 selected studies written in English (published between 2001 and 2008).Health status and patients' psychological characteristics are associated with higher levels of HRQOL impairment.The authors found that the impact of melanoma on patients' HRQOL is comparable to that of other cancers.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

ABSTRACT
Melanoma can be considered an emerging chronic disease that may considerably affect patients' lives. The authors systematically reviewed the available literature on health-related quality of life (HRQOL) and melanoma. Of reviews and the selected studies, reference lists were hand-searched. The quality of the eligible studies was appraised based on 14 previously published criteria. Of the 158 abstracts, 44 articles were appraised, resulting in 13 selected studies written in English (published between 2001 and 2008). Most studies assessed patients from specialised centres with varying, but relatively advanced, disease stages. The most commonly used instruments were the SF-36 and EORTC QLQ-C30. Recently, a melanoma-specific HRQOL questionnaire [FACT-Melanoma (FACT-M)] was introduced for clinical trial purposes. It showed that approximately one-third of melanoma patients experienced considerable levels of distress, mostly at the time of diagnosis and following treatment. Systemic therapies affected HRQOL negatively in the short term, but to a lesser extent in the long term. Health status and patients' psychological characteristics are associated with higher levels of HRQOL impairment. The authors found that the impact of melanoma on patients' HRQOL is comparable to that of other cancers. Accurately assessing HRQOL impairment in melanoma patients is pivotal, as it may affect disease management, including therapy and additional counselling, future preventive behaviour and perhaps even prognosis.

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Related in: MedlinePlus

Flow-chart of the systematic search.
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Related In: Results  -  Collection


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fig1: Flow-chart of the systematic search.

Mentions: Systematic searches were conducted in PubMed, MEDLINE and the Cochrane Library with the assistance of a medical librarian. The search algorithm of MeSH-used terms was the following: (cutaneous OR skin) AND melanoma AND (quality of life OR life) AND (health status OR health status indicators OR survival analysis OR health-related OR health) NOT ‘non-melanoma’. Restrictions were not placed on publication dates or language. Several inclusion and exclusion criteria were used (Figure 1). The quality of the eligible studies was assessed using criteria for assessing the methodological quality of studies in HRQOL published previously (Table 2) [7]. In brief, these criteria focus on the methodological aspects of HRQOL studies, e.g. whether inclusion and exclusion criteria are well formulated, whether responders and non-responders are reported and whether the socio-demographics of the responders are known and the score range is between 0 and 14. The criteria are quite strict; if a certain criterion is not explicitly mentioned, the default is 0.


A systematic review of health-related quality of life in cutaneous melanoma.

Cornish D, Holterhues C, van de Poll-Franse LV, Coebergh JW, Nijsten T - Ann. Oncol. (2009)

Flow-chart of the systematic search.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2712593&req=5

fig1: Flow-chart of the systematic search.
Mentions: Systematic searches were conducted in PubMed, MEDLINE and the Cochrane Library with the assistance of a medical librarian. The search algorithm of MeSH-used terms was the following: (cutaneous OR skin) AND melanoma AND (quality of life OR life) AND (health status OR health status indicators OR survival analysis OR health-related OR health) NOT ‘non-melanoma’. Restrictions were not placed on publication dates or language. Several inclusion and exclusion criteria were used (Figure 1). The quality of the eligible studies was assessed using criteria for assessing the methodological quality of studies in HRQOL published previously (Table 2) [7]. In brief, these criteria focus on the methodological aspects of HRQOL studies, e.g. whether inclusion and exclusion criteria are well formulated, whether responders and non-responders are reported and whether the socio-demographics of the responders are known and the score range is between 0 and 14. The criteria are quite strict; if a certain criterion is not explicitly mentioned, the default is 0.

Bottom Line: Of the 158 abstracts, 44 articles were appraised, resulting in 13 selected studies written in English (published between 2001 and 2008).Health status and patients' psychological characteristics are associated with higher levels of HRQOL impairment.The authors found that the impact of melanoma on patients' HRQOL is comparable to that of other cancers.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

ABSTRACT
Melanoma can be considered an emerging chronic disease that may considerably affect patients' lives. The authors systematically reviewed the available literature on health-related quality of life (HRQOL) and melanoma. Of reviews and the selected studies, reference lists were hand-searched. The quality of the eligible studies was appraised based on 14 previously published criteria. Of the 158 abstracts, 44 articles were appraised, resulting in 13 selected studies written in English (published between 2001 and 2008). Most studies assessed patients from specialised centres with varying, but relatively advanced, disease stages. The most commonly used instruments were the SF-36 and EORTC QLQ-C30. Recently, a melanoma-specific HRQOL questionnaire [FACT-Melanoma (FACT-M)] was introduced for clinical trial purposes. It showed that approximately one-third of melanoma patients experienced considerable levels of distress, mostly at the time of diagnosis and following treatment. Systemic therapies affected HRQOL negatively in the short term, but to a lesser extent in the long term. Health status and patients' psychological characteristics are associated with higher levels of HRQOL impairment. The authors found that the impact of melanoma on patients' HRQOL is comparable to that of other cancers. Accurately assessing HRQOL impairment in melanoma patients is pivotal, as it may affect disease management, including therapy and additional counselling, future preventive behaviour and perhaps even prognosis.

Show MeSH
Related in: MedlinePlus