Limits...
Primary hepatic osteosarcoma.

Nawabi A, Rath S, Nissen N, Forscher C, Colquhoun S, Lee J, Geller S, Wong A, Klein AS - J. Gastrointest. Surg. (2009)

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Cedars-Sinai Medical Center, 8635 W. 3rd Street, 590 West, Los Angeles, CA 90048, USA.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Extraskeletal osteosarcoma (EOS) is a rare entity... Most human cases have been described in the soft tissues of the limb... Primary hepatic osteosarcoma is extremely uncommon with only seven cases reported in the world’s literature... The lesion extended across the falciform ligament into segment 4 of the liver... It was also adherent to, but did not invade, the stomach... She received a total of four courses of ifosfamide and two courses of cisplatin and doxorubicin with a cumulative dose of doxorubicin of 150 mg/m... The patient has been followed clinically as well as by serial CT imaging of her abdomen, pelvis, and chest... The spindle cells reacted with antibody directed against vimentin and there was no immunostaining for smooth muscle actin (SMA), S-100, desmin, epithelial membrane antigen (EMA), CD 57, or AE1/3... A high mitotic rate with greater than 80% staining for proliferative marker Ki-67 was seen... Extraskeletal osteosarcoma is a rare entity and case descriptions can be found throughout the literature mostly in the limbs and limb girdles... This may be related to the rarity of the lesion or, alternatively, that if a biopsy were to return osteoid in a large liver tumor, various more common tumors would be suspected including hepatoblastoma, hepatic teratoma, malignant mesenchymoma, carcinosarcoma, hepatic angiosarcoma, or other hepatic sarcoma... Moreover, when mixed epithelial components are present, the pattern of differentiation is essential to characterize the tumor... This would be impossible with only a needle biopsy... This case is notable for the young age at presentation (19 years old) and the prolonged disease-free survival she has experienced following surgery and adjuvant chemotherapy with multiagent chemotherapy.

Show MeSH

Related in: MedlinePlus

Cut surface of the resection specimen shows a tan-gray, rubbery, firm well-demarcated tumor with multifocal areas of hemorrhage and a thrombus at the right upper portion of the specimen. The scale shows centimeters.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2710492&req=5

Fig3: Cut surface of the resection specimen shows a tan-gray, rubbery, firm well-demarcated tumor with multifocal areas of hemorrhage and a thrombus at the right upper portion of the specimen. The scale shows centimeters.

Mentions: Pathologic examination of the left lobe resection revealed a 15.0 × 13.8 × 12.0 cm, 1,390 g well-demarcated non-encapsulated tan-gray rubbery intraparenchymal mass with diffuse punctate hemorrhagic areas involving 95% of the specimen (Fig. 3). A focal 5.5 × 4.5 × 4.5 cm gray-white calcified area was present and a thrombus was in a large portal vein. The surrounding liver parenchyma was tan-brown and non-cirrhotic appearing. The specimen was processed with formalin fixation and paraffin embedding.Figure 3


Primary hepatic osteosarcoma.

Nawabi A, Rath S, Nissen N, Forscher C, Colquhoun S, Lee J, Geller S, Wong A, Klein AS - J. Gastrointest. Surg. (2009)

Cut surface of the resection specimen shows a tan-gray, rubbery, firm well-demarcated tumor with multifocal areas of hemorrhage and a thrombus at the right upper portion of the specimen. The scale shows centimeters.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2710492&req=5

Fig3: Cut surface of the resection specimen shows a tan-gray, rubbery, firm well-demarcated tumor with multifocal areas of hemorrhage and a thrombus at the right upper portion of the specimen. The scale shows centimeters.
Mentions: Pathologic examination of the left lobe resection revealed a 15.0 × 13.8 × 12.0 cm, 1,390 g well-demarcated non-encapsulated tan-gray rubbery intraparenchymal mass with diffuse punctate hemorrhagic areas involving 95% of the specimen (Fig. 3). A focal 5.5 × 4.5 × 4.5 cm gray-white calcified area was present and a thrombus was in a large portal vein. The surrounding liver parenchyma was tan-brown and non-cirrhotic appearing. The specimen was processed with formalin fixation and paraffin embedding.Figure 3

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Cedars-Sinai Medical Center, 8635 W. 3rd Street, 590 West, Los Angeles, CA 90048, USA.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Extraskeletal osteosarcoma (EOS) is a rare entity... Most human cases have been described in the soft tissues of the limb... Primary hepatic osteosarcoma is extremely uncommon with only seven cases reported in the world’s literature... The lesion extended across the falciform ligament into segment 4 of the liver... It was also adherent to, but did not invade, the stomach... She received a total of four courses of ifosfamide and two courses of cisplatin and doxorubicin with a cumulative dose of doxorubicin of 150 mg/m... The patient has been followed clinically as well as by serial CT imaging of her abdomen, pelvis, and chest... The spindle cells reacted with antibody directed against vimentin and there was no immunostaining for smooth muscle actin (SMA), S-100, desmin, epithelial membrane antigen (EMA), CD 57, or AE1/3... A high mitotic rate with greater than 80% staining for proliferative marker Ki-67 was seen... Extraskeletal osteosarcoma is a rare entity and case descriptions can be found throughout the literature mostly in the limbs and limb girdles... This may be related to the rarity of the lesion or, alternatively, that if a biopsy were to return osteoid in a large liver tumor, various more common tumors would be suspected including hepatoblastoma, hepatic teratoma, malignant mesenchymoma, carcinosarcoma, hepatic angiosarcoma, or other hepatic sarcoma... Moreover, when mixed epithelial components are present, the pattern of differentiation is essential to characterize the tumor... This would be impossible with only a needle biopsy... This case is notable for the young age at presentation (19 years old) and the prolonged disease-free survival she has experienced following surgery and adjuvant chemotherapy with multiagent chemotherapy.

Show MeSH
Related in: MedlinePlus