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Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis.

Matos RT, Honório RS, Caldini EG, Hashimoto CL, Ferreira MA, Navarro-Rodriguez T - Clinics (Sao Paulo) (2009)

Bottom Line: Eighteen patients presented with normal esophagi (Control Group "C"), nine of whom were infused with HCl and nine with saline.Eleven patients presented with erosive esophagitis (Lesion Group "L"), five of whom were infused with HCl and six with saline.No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Faculdade de Medicina, Universidade de São Paulo, São Paulo/SP, Brazil. ritedeschi@yahoo.com.br

ABSTRACT

Unlabelled: The purpose of this study was to compare esophageal infusion with 0.1 N hydrochloric acid (HCl) to esophageal infusion with saline in patients presenting with typical gastroesophageal reflux symptoms and erosive esophagitis.

Methods: Upper gastrointestinal endoscopy was performed on 44 prospective subjects, 29 of whom were included in the study. Eighteen patients presented with normal esophagi (Control Group "C"), nine of whom were infused with HCl and nine with saline. Eleven patients presented with erosive esophagitis (Lesion Group "L"), five of whom were infused with HCl and six with saline. Biopsies of the esophageal mucosa were collected before and after infusions.

Results: No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient.

Conclusions: Response to HCl infusion cannot be used as a marker for gastroesophageal reflux disease.

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Related in: MedlinePlus

Electron micrograph of the prickle cell layer of the esophageal epithelium from a patient with a normal esophagus following HCl infusion (magnification, ×8400)
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f2-cln64_7p669: Electron micrograph of the prickle cell layer of the esophageal epithelium from a patient with a normal esophagus following HCl infusion (magnification, ×8400)

Mentions: No significant differences were found at the electron microscope level or in the morphometric analysis among the various combinations of symptom groups (i.e., with and without UGIE evidence of erosive esophagitis) or infusion groups (i.e., C and L) (p > 0.05 for all comparisons) (Tables 2 and 3; Figures 1 and 2).


Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis.

Matos RT, Honório RS, Caldini EG, Hashimoto CL, Ferreira MA, Navarro-Rodriguez T - Clinics (Sao Paulo) (2009)

Electron micrograph of the prickle cell layer of the esophageal epithelium from a patient with a normal esophagus following HCl infusion (magnification, ×8400)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2710441&req=5

f2-cln64_7p669: Electron micrograph of the prickle cell layer of the esophageal epithelium from a patient with a normal esophagus following HCl infusion (magnification, ×8400)
Mentions: No significant differences were found at the electron microscope level or in the morphometric analysis among the various combinations of symptom groups (i.e., with and without UGIE evidence of erosive esophagitis) or infusion groups (i.e., C and L) (p > 0.05 for all comparisons) (Tables 2 and 3; Figures 1 and 2).

Bottom Line: Eighteen patients presented with normal esophagi (Control Group "C"), nine of whom were infused with HCl and nine with saline.Eleven patients presented with erosive esophagitis (Lesion Group "L"), five of whom were infused with HCl and six with saline.No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Faculdade de Medicina, Universidade de São Paulo, São Paulo/SP, Brazil. ritedeschi@yahoo.com.br

ABSTRACT

Unlabelled: The purpose of this study was to compare esophageal infusion with 0.1 N hydrochloric acid (HCl) to esophageal infusion with saline in patients presenting with typical gastroesophageal reflux symptoms and erosive esophagitis.

Methods: Upper gastrointestinal endoscopy was performed on 44 prospective subjects, 29 of whom were included in the study. Eighteen patients presented with normal esophagi (Control Group "C"), nine of whom were infused with HCl and nine with saline. Eleven patients presented with erosive esophagitis (Lesion Group "L"), five of whom were infused with HCl and six with saline. Biopsies of the esophageal mucosa were collected before and after infusions.

Results: No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient.

Conclusions: Response to HCl infusion cannot be used as a marker for gastroesophageal reflux disease.

Show MeSH
Related in: MedlinePlus