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A case of lipomatous pleomorphic adenoma in the parotid gland: a case report.

Kondo T - Diagn Pathol (2009)

Bottom Line: Pleomorphic adenoma is the most common benign neoplasm of the salivary glands.Extensive lipomatous involvement of the tumor is, however, a very rare finding.Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan. kondo@med.kobe-u.ac.jp

ABSTRACT

Introduction: Pleomorphic adenoma is the most common benign neoplasm of the salivary glands. Extensive lipomatous involvement of the tumor is, however, a very rare finding.

Case report: Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.

Conclusion: This is the sixth case of lipomatous pleomorphic adenoma in the English literature. Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management. On CT scan, it may not be detected possibly due to the extensive fatty component.

No MeSH data available.


Related in: MedlinePlus

Microscopic finding of the tumor (higher magnification). AB: More than 95% of the tumor was adipose component, containing only scant epithelial components. (HE staining, AB: ×400).
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Figure 3: Microscopic finding of the tumor (higher magnification). AB: More than 95% of the tumor was adipose component, containing only scant epithelial components. (HE staining, AB: ×400).

Mentions: A 14-year-old Japanese woman presented with an asymptomatic slowly growing mass in the right preauricular region. CT scan was not performed. The patient then underwent excision of the deep lobe of the parotid gland. Grossly, the smooth surfaced lipomatous mass measured approximately 2 cm and had a uniform yellow cut surface (Fig. 1). Microscopic examination revealed a thick fibrous capsule completely surrounding the lesion (Fig. 2A). The well-encapsulated tumor consisted predominantly of mature adipose tissue (more than 95% of the entire lesion) with slight myxoid change containing only a scant epithelial element arranged in islands (Fig. 2B). Histologic images of higher magnification are shown in Fig. 3. Nuclear atypia or mitotic activity of epithelial cells was not identified. Adipocytes were univacuolar in shape, and no lipoblasts or malignant findings were identified. The tumor cells were negative for several special stains including PAS reaction (not shown). Although additional immunostaining was not performed for this case, these findings were diagnostic of a lipomatous pleomorphic adenoma. No recurrence has been experienced after surgery.


A case of lipomatous pleomorphic adenoma in the parotid gland: a case report.

Kondo T - Diagn Pathol (2009)

Microscopic finding of the tumor (higher magnification). AB: More than 95% of the tumor was adipose component, containing only scant epithelial components. (HE staining, AB: ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2710317&req=5

Figure 3: Microscopic finding of the tumor (higher magnification). AB: More than 95% of the tumor was adipose component, containing only scant epithelial components. (HE staining, AB: ×400).
Mentions: A 14-year-old Japanese woman presented with an asymptomatic slowly growing mass in the right preauricular region. CT scan was not performed. The patient then underwent excision of the deep lobe of the parotid gland. Grossly, the smooth surfaced lipomatous mass measured approximately 2 cm and had a uniform yellow cut surface (Fig. 1). Microscopic examination revealed a thick fibrous capsule completely surrounding the lesion (Fig. 2A). The well-encapsulated tumor consisted predominantly of mature adipose tissue (more than 95% of the entire lesion) with slight myxoid change containing only a scant epithelial element arranged in islands (Fig. 2B). Histologic images of higher magnification are shown in Fig. 3. Nuclear atypia or mitotic activity of epithelial cells was not identified. Adipocytes were univacuolar in shape, and no lipoblasts or malignant findings were identified. The tumor cells were negative for several special stains including PAS reaction (not shown). Although additional immunostaining was not performed for this case, these findings were diagnostic of a lipomatous pleomorphic adenoma. No recurrence has been experienced after surgery.

Bottom Line: Pleomorphic adenoma is the most common benign neoplasm of the salivary glands.Extensive lipomatous involvement of the tumor is, however, a very rare finding.Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan. kondo@med.kobe-u.ac.jp

ABSTRACT

Introduction: Pleomorphic adenoma is the most common benign neoplasm of the salivary glands. Extensive lipomatous involvement of the tumor is, however, a very rare finding.

Case report: Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.

Conclusion: This is the sixth case of lipomatous pleomorphic adenoma in the English literature. Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management. On CT scan, it may not be detected possibly due to the extensive fatty component.

No MeSH data available.


Related in: MedlinePlus