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Primary synovial sarcoma of kidney: A rare tumor with an atypical presentation.

Dassi V, Das K, Singh BP, Swain SK - Indian J Urol (2009)

Bottom Line: Here we present a case of a 20-year-old female presenting PSS of the left kidney with caval thrombus.The diagnosis was corroborated by reverse transcription polymerase chain reaction (RT-PCR).Similar cases of PSS of kidney with tumor extension in the inferior vena cava are extremely rare and to date, approximately three cases have been reported in the literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, T.N. Medical College and BYL Nair Hospital, Mumbai-400 008, India.

ABSTRACT
Synovial sarcoma (SS) is a tumor of the soft tissues with a unique chromosomal translocation t(X;18)(p11.2;q11.2) that can be detected by polymerase chain reaction in tissue homogenates. Here we present a case of a 20-year-old female presenting PSS of the left kidney with caval thrombus. The diagnosis was corroborated by reverse transcription polymerase chain reaction (RT-PCR). Similar cases of PSS of kidney with tumor extension in the inferior vena cava are extremely rare and to date, approximately three cases have been reported in the literature.

No MeSH data available.


Related in: MedlinePlus

Microscopic image showing spindle cells
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Figure 0005: Microscopic image showing spindle cells

Mentions: Microscopically, the tumor was composed of spindle cells arranged in the intersecting fascicles, alternating with hypocellular areas, suggestive of monophasic SS [Figures 4 and 5]. On immunohistochemistry, tumor cells expressed bcl-2, calponin, and EMA. Both Mic-2 and CK were focally positive. Molecular analysis revealed a translocation between the SYT gene on chromosome 18 and SSX on chromosome X, which is consistent with the diagnosis of SS.


Primary synovial sarcoma of kidney: A rare tumor with an atypical presentation.

Dassi V, Das K, Singh BP, Swain SK - Indian J Urol (2009)

Microscopic image showing spindle cells
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2710084&req=5

Figure 0005: Microscopic image showing spindle cells
Mentions: Microscopically, the tumor was composed of spindle cells arranged in the intersecting fascicles, alternating with hypocellular areas, suggestive of monophasic SS [Figures 4 and 5]. On immunohistochemistry, tumor cells expressed bcl-2, calponin, and EMA. Both Mic-2 and CK were focally positive. Molecular analysis revealed a translocation between the SYT gene on chromosome 18 and SSX on chromosome X, which is consistent with the diagnosis of SS.

Bottom Line: Here we present a case of a 20-year-old female presenting PSS of the left kidney with caval thrombus.The diagnosis was corroborated by reverse transcription polymerase chain reaction (RT-PCR).Similar cases of PSS of kidney with tumor extension in the inferior vena cava are extremely rare and to date, approximately three cases have been reported in the literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, T.N. Medical College and BYL Nair Hospital, Mumbai-400 008, India.

ABSTRACT
Synovial sarcoma (SS) is a tumor of the soft tissues with a unique chromosomal translocation t(X;18)(p11.2;q11.2) that can be detected by polymerase chain reaction in tissue homogenates. Here we present a case of a 20-year-old female presenting PSS of the left kidney with caval thrombus. The diagnosis was corroborated by reverse transcription polymerase chain reaction (RT-PCR). Similar cases of PSS of kidney with tumor extension in the inferior vena cava are extremely rare and to date, approximately three cases have been reported in the literature.

No MeSH data available.


Related in: MedlinePlus