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Post-transplant small cell carcinoma arising in the native kidney of renal transplant recipient.

Tang W, Ma L, Hou X, Yan L, Upadhyay AM - Indian J Urol (2009)

Bottom Line: Here, we report the first case of primary SCC of RTRs' own kidney.The immuno-histochemical result confirmed mixed SCC of the right kidney (SCC combined with little transitional cell carcinoma).Postoperatively, platinum-based adjuvant chemotherapy (Cisplatin combined with Gemcitabine) was given, and the patient is still alive with well-functioning transplanted kidney.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Peking University, Third Hospital, Beijing, 100083, P.R. China.

ABSTRACT
Small cell carcinoma (SCC) originating from kidney is extremely rare. To date, there has been no reported case of primary SCC of renal transplant recipients' (RTRs)' own kidney. Here, we report the first case of primary SCC of RTRs' own kidney. Resection of bilateral native kidneys, possessing whole length of ureters and small cuffs of bladder along with a neoplasm located in her right kidney, was performed on a 68-year-old female patient, five years after renal transplantation. The immuno-histochemical result confirmed mixed SCC of the right kidney (SCC combined with little transitional cell carcinoma). Postoperatively, platinum-based adjuvant chemotherapy (Cisplatin combined with Gemcitabine) was given, and the patient is still alive with well-functioning transplanted kidney.

No MeSH data available.


Related in: MedlinePlus

Contrast-enhanced CT scans: Right renal mass (CT value 42 HU) with slight enhancement (CT value 55 HU) on contrast enhancement, right hydronephrosis; multiple enlarged abdominal lymph nodes (with arrow head); and left shrunken kidney
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Figure 0001: Contrast-enhanced CT scans: Right renal mass (CT value 42 HU) with slight enhancement (CT value 55 HU) on contrast enhancement, right hydronephrosis; multiple enlarged abdominal lymph nodes (with arrow head); and left shrunken kidney

Mentions: A 68-year-old Chinese lady was presented with right renal mass after routine ultrasound examination of the abdomen. She had no obvious complaint and no history of (h/o) hematuria, loin pain, and fever. The patient had h/o cadaver renal transplant five years ago. The postoperative period was uneventful. She received Tacrolimus (FK506), Mycophenolate mofetil (MMF), and Prednisone as immunosuppressive agent. On physical examination, patient's general condition was fair, she was nonanemic, nonicteric, and no sign of peripheral lymphadenopathy was noted. Abdomen was soft with no palpable mass and hepato-splenomegaly. Ultrasonography (USG) of the abdomen revealed a mass of size 4 × 3 cm in the right kidney and several other smaller masses behind the inferior venacava (IVC), the biggest one measuring 3.3 × 2.0 cm in size. Computer tomography (CT) of the abdomen showed right renal mass (CT value 42 HU) on slight enhancement and (CT value 55 HU) on contrast enhancement, and right hydronephrosis, multiple enlarged abdominal lymph nodes, left shrunken kidney, and normal allograft in the pelvis [Figure 1]. MRI of the abdomen further showed a right renal mass of size 4.3 × 4.6 × 6 cm with high T1- and moderate T2-weighted image.


Post-transplant small cell carcinoma arising in the native kidney of renal transplant recipient.

Tang W, Ma L, Hou X, Yan L, Upadhyay AM - Indian J Urol (2009)

Contrast-enhanced CT scans: Right renal mass (CT value 42 HU) with slight enhancement (CT value 55 HU) on contrast enhancement, right hydronephrosis; multiple enlarged abdominal lymph nodes (with arrow head); and left shrunken kidney
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2710082&req=5

Figure 0001: Contrast-enhanced CT scans: Right renal mass (CT value 42 HU) with slight enhancement (CT value 55 HU) on contrast enhancement, right hydronephrosis; multiple enlarged abdominal lymph nodes (with arrow head); and left shrunken kidney
Mentions: A 68-year-old Chinese lady was presented with right renal mass after routine ultrasound examination of the abdomen. She had no obvious complaint and no history of (h/o) hematuria, loin pain, and fever. The patient had h/o cadaver renal transplant five years ago. The postoperative period was uneventful. She received Tacrolimus (FK506), Mycophenolate mofetil (MMF), and Prednisone as immunosuppressive agent. On physical examination, patient's general condition was fair, she was nonanemic, nonicteric, and no sign of peripheral lymphadenopathy was noted. Abdomen was soft with no palpable mass and hepato-splenomegaly. Ultrasonography (USG) of the abdomen revealed a mass of size 4 × 3 cm in the right kidney and several other smaller masses behind the inferior venacava (IVC), the biggest one measuring 3.3 × 2.0 cm in size. Computer tomography (CT) of the abdomen showed right renal mass (CT value 42 HU) on slight enhancement and (CT value 55 HU) on contrast enhancement, and right hydronephrosis, multiple enlarged abdominal lymph nodes, left shrunken kidney, and normal allograft in the pelvis [Figure 1]. MRI of the abdomen further showed a right renal mass of size 4.3 × 4.6 × 6 cm with high T1- and moderate T2-weighted image.

Bottom Line: Here, we report the first case of primary SCC of RTRs' own kidney.The immuno-histochemical result confirmed mixed SCC of the right kidney (SCC combined with little transitional cell carcinoma).Postoperatively, platinum-based adjuvant chemotherapy (Cisplatin combined with Gemcitabine) was given, and the patient is still alive with well-functioning transplanted kidney.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Peking University, Third Hospital, Beijing, 100083, P.R. China.

ABSTRACT
Small cell carcinoma (SCC) originating from kidney is extremely rare. To date, there has been no reported case of primary SCC of renal transplant recipients' (RTRs)' own kidney. Here, we report the first case of primary SCC of RTRs' own kidney. Resection of bilateral native kidneys, possessing whole length of ureters and small cuffs of bladder along with a neoplasm located in her right kidney, was performed on a 68-year-old female patient, five years after renal transplantation. The immuno-histochemical result confirmed mixed SCC of the right kidney (SCC combined with little transitional cell carcinoma). Postoperatively, platinum-based adjuvant chemotherapy (Cisplatin combined with Gemcitabine) was given, and the patient is still alive with well-functioning transplanted kidney.

No MeSH data available.


Related in: MedlinePlus