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Small-cell prostate carcinoma: A retrospective analysis of five newly reported cases.

Brownback KR, Renzulli J, Delellis R, Myers JR - Indian J Urol (2009)

Bottom Line: The PSA levels varied greatly, with two patients possessing markedly elevated levels and the remaining patients with normal levels.Approximately 3/5 patients developed liver metastases, 2/5 patients had bone metastases, and 1/5 patients developed carcinomatous meningitis.Of the four patients who expired, the median survival time after diagnosis of SCC was 3.6 months (0.5-12 months).

View Article: PubMed Central - PubMed

Affiliation: Departments of Urology, Pathology, and Medicine, Brown University, Warren Alpert School of Medicine, USA.

ABSTRACT
Five cases of small-cell carcinoma (SCC) of prostate were identified, at the Rhode Island Hospital and the Miriam Hospital from 1984 to 2006, with an average age of 71 years at the time of diagnosis. Three of these patients had a prior diagnosis of prostatic adenocarcinoma, with all of the five patients receiving anti-androgen treatment. The average time between the diagnosis of adenocarcinoma and of SCC in these patients was 6.7 years. The PSA levels varied greatly, with two patients possessing markedly elevated levels and the remaining patients with normal levels. Approximately 3/5 patients developed liver metastases, 2/5 patients had bone metastases, and 1/5 patients developed carcinomatous meningitis. Of the four patients who expired, the median survival time after diagnosis of SCC was 3.6 months (0.5-12 months).

No MeSH data available.


Related in: MedlinePlus

A 10× magnification H&E stain of the initial prostate biopsy of case 4 when he was diagnosed with prostatic adenocarcinoma ten years prior to this presentation.
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Figure 0001: A 10× magnification H&E stain of the initial prostate biopsy of case 4 when he was diagnosed with prostatic adenocarcinoma ten years prior to this presentation.

Mentions: The patient was an 80-year-old male and his past medical history was significant for prostatic adenocarcinoma, diagnosed 12 years earlier [Figure 1]. He had been treated with external beam radiation, followed by a transurethral resection nine years later, and subsequently a bicalutamide treatment. The current admission was precipitated by multiple episodes of urinary obstruction and hematuria that started 10 days prior to admission.


Small-cell prostate carcinoma: A retrospective analysis of five newly reported cases.

Brownback KR, Renzulli J, Delellis R, Myers JR - Indian J Urol (2009)

A 10× magnification H&E stain of the initial prostate biopsy of case 4 when he was diagnosed with prostatic adenocarcinoma ten years prior to this presentation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2710081&req=5

Figure 0001: A 10× magnification H&E stain of the initial prostate biopsy of case 4 when he was diagnosed with prostatic adenocarcinoma ten years prior to this presentation.
Mentions: The patient was an 80-year-old male and his past medical history was significant for prostatic adenocarcinoma, diagnosed 12 years earlier [Figure 1]. He had been treated with external beam radiation, followed by a transurethral resection nine years later, and subsequently a bicalutamide treatment. The current admission was precipitated by multiple episodes of urinary obstruction and hematuria that started 10 days prior to admission.

Bottom Line: The PSA levels varied greatly, with two patients possessing markedly elevated levels and the remaining patients with normal levels.Approximately 3/5 patients developed liver metastases, 2/5 patients had bone metastases, and 1/5 patients developed carcinomatous meningitis.Of the four patients who expired, the median survival time after diagnosis of SCC was 3.6 months (0.5-12 months).

View Article: PubMed Central - PubMed

Affiliation: Departments of Urology, Pathology, and Medicine, Brown University, Warren Alpert School of Medicine, USA.

ABSTRACT
Five cases of small-cell carcinoma (SCC) of prostate were identified, at the Rhode Island Hospital and the Miriam Hospital from 1984 to 2006, with an average age of 71 years at the time of diagnosis. Three of these patients had a prior diagnosis of prostatic adenocarcinoma, with all of the five patients receiving anti-androgen treatment. The average time between the diagnosis of adenocarcinoma and of SCC in these patients was 6.7 years. The PSA levels varied greatly, with two patients possessing markedly elevated levels and the remaining patients with normal levels. Approximately 3/5 patients developed liver metastases, 2/5 patients had bone metastases, and 1/5 patients developed carcinomatous meningitis. Of the four patients who expired, the median survival time after diagnosis of SCC was 3.6 months (0.5-12 months).

No MeSH data available.


Related in: MedlinePlus