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Effect of buspirone on thermal sensory and pain thresholds in human volunteers.

Pavlaković G, Tigges J, Crozier TA - BMC Clin Pharmacol (2009)

Bottom Line: Buspirone caused mild sedation in six participants at 60 minutes, but was without effect on any of the measured parameters.Buspirone in the maximal recommended dose was without significant effect on thermal pain.However, as it is only a partial agonist at the 5-HT1A receptor and also acts on other receptor types, the negative results of the present study do not rule out a possible analgesic effect of more specific 5-HT1A receptor agonists.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen Medical School, Göttingen, Germany. pavlakovic@gmx.net

ABSTRACT

Background: Buspirone is a partial 5-HT1A receptor agonist. Animal studies have shown that modulation of serotoninergic transmission at the 5-HT1A receptor can induce analgesia in acute pain models. However, no studies have been published so far on the effects of serotonin receptor agonists on pain perception in humans.

Methods: The effects of buspirone (30 mg p.o.) on thermal sensory and pain thresholds were investigated in twelve female volunteers (26 +/- 2 yrs) in a prospective, randomized, double-blind, double-dummy, placebo-controlled study with morphine (10 mg i.v.) as positive control.

Results: Morphine significantly increased the heat pain detection threshold (DeltaT: placebo 1.0 degrees C and 1.3 degrees C, p < 0.05) at 60 minutes. Buspirone caused mild sedation in six participants at 60 minutes, but was without effect on any of the measured parameters.

Conclusion: Buspirone in the maximal recommended dose was without significant effect on thermal pain. However, as it is only a partial agonist at the 5-HT1A receptor and also acts on other receptor types, the negative results of the present study do not rule out a possible analgesic effect of more specific 5-HT1A receptor agonists.

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Hemodynamic parameters. Hemodynamic parameters 60 and 120 minutes following buspirone and morphine administration: The values are expressed as change in the blood pressure or heart rate from the pre-treatment value. a) Systolic blood pressure change, b) Heart rate change. Blood pressure and heart rate changes following the two drugs were not significantly different than with placebo (p < 0.05). BP0', BP60', BP120' = systolic blood pressure at the time of drug administration (0) and 60 and 120 minutes after drug administration. HR0', HR60', HR120' = heart rate at the time of drug administration (0) and 60 and 120 minutes after drug administration.
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Figure 1: Hemodynamic parameters. Hemodynamic parameters 60 and 120 minutes following buspirone and morphine administration: The values are expressed as change in the blood pressure or heart rate from the pre-treatment value. a) Systolic blood pressure change, b) Heart rate change. Blood pressure and heart rate changes following the two drugs were not significantly different than with placebo (p < 0.05). BP0', BP60', BP120' = systolic blood pressure at the time of drug administration (0) and 60 and 120 minutes after drug administration. HR0', HR60', HR120' = heart rate at the time of drug administration (0) and 60 and 120 minutes after drug administration.

Mentions: All participants were cooperative and tranquil (Ramsay score 2) at the start of each session. Blood pressure and heart rate were not affected by either of the tested substances at any tested time point (Figure 1).


Effect of buspirone on thermal sensory and pain thresholds in human volunteers.

Pavlaković G, Tigges J, Crozier TA - BMC Clin Pharmacol (2009)

Hemodynamic parameters. Hemodynamic parameters 60 and 120 minutes following buspirone and morphine administration: The values are expressed as change in the blood pressure or heart rate from the pre-treatment value. a) Systolic blood pressure change, b) Heart rate change. Blood pressure and heart rate changes following the two drugs were not significantly different than with placebo (p < 0.05). BP0', BP60', BP120' = systolic blood pressure at the time of drug administration (0) and 60 and 120 minutes after drug administration. HR0', HR60', HR120' = heart rate at the time of drug administration (0) and 60 and 120 minutes after drug administration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2698897&req=5

Figure 1: Hemodynamic parameters. Hemodynamic parameters 60 and 120 minutes following buspirone and morphine administration: The values are expressed as change in the blood pressure or heart rate from the pre-treatment value. a) Systolic blood pressure change, b) Heart rate change. Blood pressure and heart rate changes following the two drugs were not significantly different than with placebo (p < 0.05). BP0', BP60', BP120' = systolic blood pressure at the time of drug administration (0) and 60 and 120 minutes after drug administration. HR0', HR60', HR120' = heart rate at the time of drug administration (0) and 60 and 120 minutes after drug administration.
Mentions: All participants were cooperative and tranquil (Ramsay score 2) at the start of each session. Blood pressure and heart rate were not affected by either of the tested substances at any tested time point (Figure 1).

Bottom Line: Buspirone caused mild sedation in six participants at 60 minutes, but was without effect on any of the measured parameters.Buspirone in the maximal recommended dose was without significant effect on thermal pain.However, as it is only a partial agonist at the 5-HT1A receptor and also acts on other receptor types, the negative results of the present study do not rule out a possible analgesic effect of more specific 5-HT1A receptor agonists.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen Medical School, Göttingen, Germany. pavlakovic@gmx.net

ABSTRACT

Background: Buspirone is a partial 5-HT1A receptor agonist. Animal studies have shown that modulation of serotoninergic transmission at the 5-HT1A receptor can induce analgesia in acute pain models. However, no studies have been published so far on the effects of serotonin receptor agonists on pain perception in humans.

Methods: The effects of buspirone (30 mg p.o.) on thermal sensory and pain thresholds were investigated in twelve female volunteers (26 +/- 2 yrs) in a prospective, randomized, double-blind, double-dummy, placebo-controlled study with morphine (10 mg i.v.) as positive control.

Results: Morphine significantly increased the heat pain detection threshold (DeltaT: placebo 1.0 degrees C and 1.3 degrees C, p < 0.05) at 60 minutes. Buspirone caused mild sedation in six participants at 60 minutes, but was without effect on any of the measured parameters.

Conclusion: Buspirone in the maximal recommended dose was without significant effect on thermal pain. However, as it is only a partial agonist at the 5-HT1A receptor and also acts on other receptor types, the negative results of the present study do not rule out a possible analgesic effect of more specific 5-HT1A receptor agonists.

Show MeSH
Related in: MedlinePlus