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Periodontal conditions, oral Candida albicans and salivary proteins in type 2 diabetic subjects with emphasis on gender.

Javed F, Klingspor L, Sundin U, Altamash M, Klinge B, Engström PE - BMC Oral Health (2009)

Bottom Line: Periodontal conditions (PI [p < 0.00001], BOP [p < 0.01] and PD of 4 to 6 mm [p < 0.001], salivary IgG (microg)/mg protein (p < 0.001) and salivary total protein concentrations (p < 0.05) were higher in type 2 diabetic females with Candida albicans (C. albicans) colonisation compared to males in the same group.Type 2 diabetic females with C. albicans colonisation had more teeth compared to males in the same group (p < 0.0001).Clinical and salivary parameters of periodontal inflammation (BOP and IgG (mug)/mg protein) were higher in type 2 diabetic females with oral C. albicans colonisation compared to males in the same group.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden. fawad.javed@ki.se

ABSTRACT

Background: The association between periodontal conditions, oral yeast colonisation and salivary proteins in subjects with type 2 diabetes (T2D) is not yet documented. The present study aimed to assess the relationship between these variables in type 2 diabetic subjects with reference to gender.

Methods: Fifty-eight type 2 diabetic subjects (23 males and 35 females) with random blood glucose level >or= 11.1 mmol/L were investigated. Periodontal conditions (plaque index [PI], bleeding on probing [BOP], probing pocket depth [PD] (4 to 6 mm and >or= 6 mm), oral yeasts, salivary immunoglobulin (Ig) A, IgG and total protein concentrations, and number of present teeth were determined.

Results: Periodontal conditions (PI [p < 0.00001], BOP [p < 0.01] and PD of 4 to 6 mm [p < 0.001], salivary IgG (microg)/mg protein (p < 0.001) and salivary total protein concentrations (p < 0.05) were higher in type 2 diabetic females with Candida albicans (C. albicans) colonisation compared to males in the same group. Type 2 diabetic females with C. albicans colonisation had more teeth compared to males in the same group (p < 0.0001).

Conclusion: Clinical and salivary parameters of periodontal inflammation (BOP and IgG (mug)/mg protein) were higher in type 2 diabetic females with oral C. albicans colonisation compared to males in the same group. Further studies are warranted to evaluate the association of gender with these variables in subjects with T2D.

No MeSH data available.


Related in: MedlinePlus

Salivary IgG (μg)/mg protein and IgA (μg)/mg protein concentrations in type 2 diabetic subjects with and without oral C. albicans colonization in relation to gender. # p < 0.001 indicates a higher concentration of salivary IgG (μg)/mg protein concentration in type 2 diabetic females compared to males with T2D and oral C. albicans colonization. Differences in levels of salivary IgG (μg)/mg protein and IgA (μg)/mg protein in type 2 diabetic males and females with and without oral Candida albicans (C. albicans) colonisation were tested using multiple logistic regression. Data are mean ± 2 standard deviations.
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Figure 2: Salivary IgG (μg)/mg protein and IgA (μg)/mg protein concentrations in type 2 diabetic subjects with and without oral C. albicans colonization in relation to gender. # p < 0.001 indicates a higher concentration of salivary IgG (μg)/mg protein concentration in type 2 diabetic females compared to males with T2D and oral C. albicans colonization. Differences in levels of salivary IgG (μg)/mg protein and IgA (μg)/mg protein in type 2 diabetic males and females with and without oral Candida albicans (C. albicans) colonisation were tested using multiple logistic regression. Data are mean ± 2 standard deviations.

Mentions: Females with C. albicans colonisation had higher levels of IgG (μg)/mg protein (p < 0.001) and total protein concentration (p < 0.05) compared to males with C. albicans. These results are shown in Figure 2 and Figure 3. The females also had more teeth (mean number of teeth19.5; range 13–21 teeth) compared with the males (mean number of teeth 12; range 10–16 teeth) (p < 0.0001).


Periodontal conditions, oral Candida albicans and salivary proteins in type 2 diabetic subjects with emphasis on gender.

Javed F, Klingspor L, Sundin U, Altamash M, Klinge B, Engström PE - BMC Oral Health (2009)

Salivary IgG (μg)/mg protein and IgA (μg)/mg protein concentrations in type 2 diabetic subjects with and without oral C. albicans colonization in relation to gender. # p < 0.001 indicates a higher concentration of salivary IgG (μg)/mg protein concentration in type 2 diabetic females compared to males with T2D and oral C. albicans colonization. Differences in levels of salivary IgG (μg)/mg protein and IgA (μg)/mg protein in type 2 diabetic males and females with and without oral Candida albicans (C. albicans) colonisation were tested using multiple logistic regression. Data are mean ± 2 standard deviations.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2698828&req=5

Figure 2: Salivary IgG (μg)/mg protein and IgA (μg)/mg protein concentrations in type 2 diabetic subjects with and without oral C. albicans colonization in relation to gender. # p < 0.001 indicates a higher concentration of salivary IgG (μg)/mg protein concentration in type 2 diabetic females compared to males with T2D and oral C. albicans colonization. Differences in levels of salivary IgG (μg)/mg protein and IgA (μg)/mg protein in type 2 diabetic males and females with and without oral Candida albicans (C. albicans) colonisation were tested using multiple logistic regression. Data are mean ± 2 standard deviations.
Mentions: Females with C. albicans colonisation had higher levels of IgG (μg)/mg protein (p < 0.001) and total protein concentration (p < 0.05) compared to males with C. albicans. These results are shown in Figure 2 and Figure 3. The females also had more teeth (mean number of teeth19.5; range 13–21 teeth) compared with the males (mean number of teeth 12; range 10–16 teeth) (p < 0.0001).

Bottom Line: Periodontal conditions (PI [p < 0.00001], BOP [p < 0.01] and PD of 4 to 6 mm [p < 0.001], salivary IgG (microg)/mg protein (p < 0.001) and salivary total protein concentrations (p < 0.05) were higher in type 2 diabetic females with Candida albicans (C. albicans) colonisation compared to males in the same group.Type 2 diabetic females with C. albicans colonisation had more teeth compared to males in the same group (p < 0.0001).Clinical and salivary parameters of periodontal inflammation (BOP and IgG (mug)/mg protein) were higher in type 2 diabetic females with oral C. albicans colonisation compared to males in the same group.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden. fawad.javed@ki.se

ABSTRACT

Background: The association between periodontal conditions, oral yeast colonisation and salivary proteins in subjects with type 2 diabetes (T2D) is not yet documented. The present study aimed to assess the relationship between these variables in type 2 diabetic subjects with reference to gender.

Methods: Fifty-eight type 2 diabetic subjects (23 males and 35 females) with random blood glucose level >or= 11.1 mmol/L were investigated. Periodontal conditions (plaque index [PI], bleeding on probing [BOP], probing pocket depth [PD] (4 to 6 mm and >or= 6 mm), oral yeasts, salivary immunoglobulin (Ig) A, IgG and total protein concentrations, and number of present teeth were determined.

Results: Periodontal conditions (PI [p < 0.00001], BOP [p < 0.01] and PD of 4 to 6 mm [p < 0.001], salivary IgG (microg)/mg protein (p < 0.001) and salivary total protein concentrations (p < 0.05) were higher in type 2 diabetic females with Candida albicans (C. albicans) colonisation compared to males in the same group. Type 2 diabetic females with C. albicans colonisation had more teeth compared to males in the same group (p < 0.0001).

Conclusion: Clinical and salivary parameters of periodontal inflammation (BOP and IgG (mug)/mg protein) were higher in type 2 diabetic females with oral C. albicans colonisation compared to males in the same group. Further studies are warranted to evaluate the association of gender with these variables in subjects with T2D.

No MeSH data available.


Related in: MedlinePlus