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Ocular sarcoidosis in a Korean population.

Lee SY, Lee HG, Kim DS, Kim JG, Chung H, Yoon YH - J. Korean Med. Sci. (2009)

Bottom Line: Mean duration of ophthalmologic follow-up was 62 months.All ocular inflammation was well managed with topical steroid and/or systemic steroid with relatively good final visual outcomes.Ocular complications such as cataract (12 eyes, 30%), glaucoma (6 eyes, 15%), vitreous opacity (1 eye, 3%), cystoid macular edema (3 eyes, 7%), neovascularization (2 eye, 5%), and epiretinal membrane (4 eye, 10%) were related to ocular sarcoidosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

ABSTRACT
The aim of current study was to evaluate the incidence and characteristics of ocular sarcoidosis in a Korean population. We conducted a retrospective study of 104 consecutive patients with biopsy-proven sarcoidosis seen at Asan Medical Center in Seoul, Korea, from 1993 to 2007. Medical records, photographs, and fluorescein angiograms were reviewed. Of 104 patients, 22 (21%) had intraocular involvement with female predominance (86%, M:F=3:19). Of the 39 eyes with ocular involvement, 16 (41%) eyes had isolated anterior uveitis, 12 (31%) eyes had intermediate uveitis, 6 eyes (15%) had panuveitis with retinal vasculitis, and 5 (13%) eyes had panuveitis with punched multifocal choroiditis. Mean duration of ophthalmologic follow-up was 62 months. All ocular inflammation was well managed with topical steroid and/or systemic steroid with relatively good final visual outcomes. Ocular complications such as cataract (12 eyes, 30%), glaucoma (6 eyes, 15%), vitreous opacity (1 eye, 3%), cystoid macular edema (3 eyes, 7%), neovascularization (2 eye, 5%), and epiretinal membrane (4 eye, 10%) were related to ocular sarcoidosis. In Korea, where sarcoidosis is very rare, our study indicates relatively low ocular and predominantly non posterior segment involvement with relatively good visual prognosis.

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Patient No. 21. Fundus photographs show subacute multifocal choroiditis with accompanying vitreous opacity at initial presentation (A, B) and residual choroiditis accompanying atrophic change at one month later (C, D). Fluorescence angiography of right inferonasal aspect and left posterior pole of retina at one month later from initial presentation (E, F) show atrophic choroidal changes.
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Figure 3: Patient No. 21. Fundus photographs show subacute multifocal choroiditis with accompanying vitreous opacity at initial presentation (A, B) and residual choroiditis accompanying atrophic change at one month later (C, D). Fluorescence angiography of right inferonasal aspect and left posterior pole of retina at one month later from initial presentation (E, F) show atrophic choroidal changes.

Mentions: Ophthalmologic manifestations of 22 patients with ocular involvement were summarized in Table 2. Bilateral ocular involvement was seen in 17 patients (77%) and it was not always symmetrical. Of 39 eyes, 16 (41%) had anterior uveitis, 12 (31%) had intermediate uveitis and 11 (28%) had posterior involvement, which was classified as, panuveitis with retina vasculitis in 6 (15%) (Fig. 2) and panuveitis with punched multifocal choroiditis in 5 (13%) (Fig. 3). Age comparisons among the four types of uveitis are presented in Fig. 1. Interestingly, all 3 patients (5 eyes) showing panuveitis with punched multifocal choroiditis were women over 55 yr old.


Ocular sarcoidosis in a Korean population.

Lee SY, Lee HG, Kim DS, Kim JG, Chung H, Yoon YH - J. Korean Med. Sci. (2009)

Patient No. 21. Fundus photographs show subacute multifocal choroiditis with accompanying vitreous opacity at initial presentation (A, B) and residual choroiditis accompanying atrophic change at one month later (C, D). Fluorescence angiography of right inferonasal aspect and left posterior pole of retina at one month later from initial presentation (E, F) show atrophic choroidal changes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2698185&req=5

Figure 3: Patient No. 21. Fundus photographs show subacute multifocal choroiditis with accompanying vitreous opacity at initial presentation (A, B) and residual choroiditis accompanying atrophic change at one month later (C, D). Fluorescence angiography of right inferonasal aspect and left posterior pole of retina at one month later from initial presentation (E, F) show atrophic choroidal changes.
Mentions: Ophthalmologic manifestations of 22 patients with ocular involvement were summarized in Table 2. Bilateral ocular involvement was seen in 17 patients (77%) and it was not always symmetrical. Of 39 eyes, 16 (41%) had anterior uveitis, 12 (31%) had intermediate uveitis and 11 (28%) had posterior involvement, which was classified as, panuveitis with retina vasculitis in 6 (15%) (Fig. 2) and panuveitis with punched multifocal choroiditis in 5 (13%) (Fig. 3). Age comparisons among the four types of uveitis are presented in Fig. 1. Interestingly, all 3 patients (5 eyes) showing panuveitis with punched multifocal choroiditis were women over 55 yr old.

Bottom Line: Mean duration of ophthalmologic follow-up was 62 months.All ocular inflammation was well managed with topical steroid and/or systemic steroid with relatively good final visual outcomes.Ocular complications such as cataract (12 eyes, 30%), glaucoma (6 eyes, 15%), vitreous opacity (1 eye, 3%), cystoid macular edema (3 eyes, 7%), neovascularization (2 eye, 5%), and epiretinal membrane (4 eye, 10%) were related to ocular sarcoidosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

ABSTRACT
The aim of current study was to evaluate the incidence and characteristics of ocular sarcoidosis in a Korean population. We conducted a retrospective study of 104 consecutive patients with biopsy-proven sarcoidosis seen at Asan Medical Center in Seoul, Korea, from 1993 to 2007. Medical records, photographs, and fluorescein angiograms were reviewed. Of 104 patients, 22 (21%) had intraocular involvement with female predominance (86%, M:F=3:19). Of the 39 eyes with ocular involvement, 16 (41%) eyes had isolated anterior uveitis, 12 (31%) eyes had intermediate uveitis, 6 eyes (15%) had panuveitis with retinal vasculitis, and 5 (13%) eyes had panuveitis with punched multifocal choroiditis. Mean duration of ophthalmologic follow-up was 62 months. All ocular inflammation was well managed with topical steroid and/or systemic steroid with relatively good final visual outcomes. Ocular complications such as cataract (12 eyes, 30%), glaucoma (6 eyes, 15%), vitreous opacity (1 eye, 3%), cystoid macular edema (3 eyes, 7%), neovascularization (2 eye, 5%), and epiretinal membrane (4 eye, 10%) were related to ocular sarcoidosis. In Korea, where sarcoidosis is very rare, our study indicates relatively low ocular and predominantly non posterior segment involvement with relatively good visual prognosis.

Show MeSH
Related in: MedlinePlus