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Automated lung nodule detection at low-dose CT: preliminary experience.

Goo JM, Lee JW, Lee HJ, Kim S, Kim JH, Im JG - Korean J Radiol (2003 Oct-Dec)

Bottom Line: Three of these, identified only at CAD, formed part of the data used to derive the gold standard.There were 8.0+/-5.2 false-positive CAD results per CT study.These preliminary results indicate that a CAD system may improve the detection of pulmonary nodules at low-dose CT.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul National University College of Medicine, and the Institute of Radiation Medicine, SNUMRC, Seoul, Korea. jmgoo@plaza.snu.ac.kr

ABSTRACT

Objective: To determine the usefulness of a computer-aided diagnosis (CAD) system for the automated detection of lung nodules at low-dose CT.

Materials and methods: A CAD system developed for detecting lung nodules was used to process the data provided by 50 consecutive low-dose CT scans. The results of an initial report, a second look review by two chest radiologists, and those obtained by the CAD system were compared, and by reviewing all of these, a gold standard was established.

Results: By applying the gold standard, a total of 52 nodules were identified (26 with a diameter < or = 5 mm; 26 with a diameter >5 mm). Compared to an initial report, four additional nodules were detected by the CAD system. Three of these, identified only at CAD, formed part of the data used to derive the gold standard. For the detection of nodules >5 mm in diameter, sensitivity was 77% for the initial report, 88% for the second look review, and 65% for the CAD system. There were 8.0+/-5.2 false-positive CAD results per CT study.

Conclusion: These preliminary results indicate that a CAD system may improve the detection of pulmonary nodules at low-dose CT.

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Related in: MedlinePlus

A 6-mm nodule in the left lower lobe (arrow) adjacent to the diaphragm was detected only by the CAD system and missed by radiologists, though it was visible in retrospect.
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Figure 1: A 6-mm nodule in the left lower lobe (arrow) adjacent to the diaphragm was detected only by the CAD system and missed by radiologists, though it was visible in retrospect.

Mentions: The results are summarized in Tables 1 and 2. Forty nodules were initially detected, and their mean diameter was 7.2±5.0 (range 3-24) mm. Individual diameters were ≤ 5 mm (n=20), 6-10 mm (n=12), or > 10 mm (n=8). At second look review, nine additional nodules were detected; the diameter of six of these was ≤ 5 mm, and that of the remaining three was 6-10 mm. After reviewing the CT data using the CAD system, three nodules were added to the gold standard (Fig. 1). Of the three nodules additionally identified during the second look review, one was detected by the CAD system (Fig. 2); compared to the initial report, a total of four additional nodules were detected by the CAD system. Thus, by applying the gold standard, a total of 52 nodules were identified (diameter ≤ 5 mm: 26; diameter > 5 mm: 26).


Automated lung nodule detection at low-dose CT: preliminary experience.

Goo JM, Lee JW, Lee HJ, Kim S, Kim JH, Im JG - Korean J Radiol (2003 Oct-Dec)

A 6-mm nodule in the left lower lobe (arrow) adjacent to the diaphragm was detected only by the CAD system and missed by radiologists, though it was visible in retrospect.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2698098&req=5

Figure 1: A 6-mm nodule in the left lower lobe (arrow) adjacent to the diaphragm was detected only by the CAD system and missed by radiologists, though it was visible in retrospect.
Mentions: The results are summarized in Tables 1 and 2. Forty nodules were initially detected, and their mean diameter was 7.2±5.0 (range 3-24) mm. Individual diameters were ≤ 5 mm (n=20), 6-10 mm (n=12), or > 10 mm (n=8). At second look review, nine additional nodules were detected; the diameter of six of these was ≤ 5 mm, and that of the remaining three was 6-10 mm. After reviewing the CT data using the CAD system, three nodules were added to the gold standard (Fig. 1). Of the three nodules additionally identified during the second look review, one was detected by the CAD system (Fig. 2); compared to the initial report, a total of four additional nodules were detected by the CAD system. Thus, by applying the gold standard, a total of 52 nodules were identified (diameter ≤ 5 mm: 26; diameter > 5 mm: 26).

Bottom Line: Three of these, identified only at CAD, formed part of the data used to derive the gold standard.There were 8.0+/-5.2 false-positive CAD results per CT study.These preliminary results indicate that a CAD system may improve the detection of pulmonary nodules at low-dose CT.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul National University College of Medicine, and the Institute of Radiation Medicine, SNUMRC, Seoul, Korea. jmgoo@plaza.snu.ac.kr

ABSTRACT

Objective: To determine the usefulness of a computer-aided diagnosis (CAD) system for the automated detection of lung nodules at low-dose CT.

Materials and methods: A CAD system developed for detecting lung nodules was used to process the data provided by 50 consecutive low-dose CT scans. The results of an initial report, a second look review by two chest radiologists, and those obtained by the CAD system were compared, and by reviewing all of these, a gold standard was established.

Results: By applying the gold standard, a total of 52 nodules were identified (26 with a diameter < or = 5 mm; 26 with a diameter >5 mm). Compared to an initial report, four additional nodules were detected by the CAD system. Three of these, identified only at CAD, formed part of the data used to derive the gold standard. For the detection of nodules >5 mm in diameter, sensitivity was 77% for the initial report, 88% for the second look review, and 65% for the CAD system. There were 8.0+/-5.2 false-positive CAD results per CT study.

Conclusion: These preliminary results indicate that a CAD system may improve the detection of pulmonary nodules at low-dose CT.

Show MeSH
Related in: MedlinePlus