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Hematocrit and mean arterial blood pressure in pre- and postmenopause women.

Vázquez BY, Vázquez MA, Intaglietta M, de Faire U, Fagrell B, Cabrales P - Vasc Health Risk Manag (2009)

Bottom Line: Premenopause women show a negative trend between parameters that is not statistically significant.It is proposed that that this MAP/Hct relationship is in part due to differences in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in blood viscosity due to changes in Hct.Comparison with a large group of postmenopause women in the city of Stockholm showed identical trends.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92037-0412, USA. borrego209@hotmail.com

ABSTRACT
The relationship between mean arterial blood pressure (MAP) and hematocrit (Hct) was studied in pre- and postmenopause women in the city of Durango, Mexico. Premenopause women show a negative trend between parameters that is not statistically significant. MAP and Hct are directly related in postmenopause women (p < 0.01). It is proposed that that this MAP/Hct relationship is in part due to differences in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in blood viscosity due to changes in Hct. Comparison with a large group of postmenopause women in the city of Stockholm showed identical trends.

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Comparison of the trends for MAP vs Hct for women aged > 60 years in a study in the city of Stockholm (n = 2,189) and postmenopause women in the city of Durango (n = 92).Abbreviations: Hct, hematocrit; MAP, mean arterial blood pressure.
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f3-vhrm-5-483: Comparison of the trends for MAP vs Hct for women aged > 60 years in a study in the city of Stockholm (n = 2,189) and postmenopause women in the city of Durango (n = 92).Abbreviations: Hct, hematocrit; MAP, mean arterial blood pressure.

Mentions: Information on the relationship between MAP and Hct is available from a study carried out in the city of Stockholm, Sweden in a population of n = 2,189 women aged >60 years. The results of this comparison shown in Figure 3 is solely presented to show that populations present identical trends in the relationship between MAP and Hct, a result suggested by clinical10 and experimental studies.6 Notably the slopes of the two regression lines are virtually identical since the relationship for the Stockholm population has slope m = 1.12 ± 0.09 vs m = 1.09 ± 0.35 mmHg/% for the population in Durango. Therefore a reduced capacity to regulate for the increase in Hct associated with menopause could be a characteristic for menopause. As expected, given the large number of subjects in the Stockholm group, the linear regression was significant (p < 0.0001). These findings may also indicate that age per se may be a factor in lowering the capacity for autoregulation of MAP vs Hct, due to factors other than endothelial dysfunction.


Hematocrit and mean arterial blood pressure in pre- and postmenopause women.

Vázquez BY, Vázquez MA, Intaglietta M, de Faire U, Fagrell B, Cabrales P - Vasc Health Risk Manag (2009)

Comparison of the trends for MAP vs Hct for women aged > 60 years in a study in the city of Stockholm (n = 2,189) and postmenopause women in the city of Durango (n = 92).Abbreviations: Hct, hematocrit; MAP, mean arterial blood pressure.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2697582&req=5

f3-vhrm-5-483: Comparison of the trends for MAP vs Hct for women aged > 60 years in a study in the city of Stockholm (n = 2,189) and postmenopause women in the city of Durango (n = 92).Abbreviations: Hct, hematocrit; MAP, mean arterial blood pressure.
Mentions: Information on the relationship between MAP and Hct is available from a study carried out in the city of Stockholm, Sweden in a population of n = 2,189 women aged >60 years. The results of this comparison shown in Figure 3 is solely presented to show that populations present identical trends in the relationship between MAP and Hct, a result suggested by clinical10 and experimental studies.6 Notably the slopes of the two regression lines are virtually identical since the relationship for the Stockholm population has slope m = 1.12 ± 0.09 vs m = 1.09 ± 0.35 mmHg/% for the population in Durango. Therefore a reduced capacity to regulate for the increase in Hct associated with menopause could be a characteristic for menopause. As expected, given the large number of subjects in the Stockholm group, the linear regression was significant (p < 0.0001). These findings may also indicate that age per se may be a factor in lowering the capacity for autoregulation of MAP vs Hct, due to factors other than endothelial dysfunction.

Bottom Line: Premenopause women show a negative trend between parameters that is not statistically significant.It is proposed that that this MAP/Hct relationship is in part due to differences in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in blood viscosity due to changes in Hct.Comparison with a large group of postmenopause women in the city of Stockholm showed identical trends.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92037-0412, USA. borrego209@hotmail.com

ABSTRACT
The relationship between mean arterial blood pressure (MAP) and hematocrit (Hct) was studied in pre- and postmenopause women in the city of Durango, Mexico. Premenopause women show a negative trend between parameters that is not statistically significant. MAP and Hct are directly related in postmenopause women (p < 0.01). It is proposed that that this MAP/Hct relationship is in part due to differences in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in blood viscosity due to changes in Hct. Comparison with a large group of postmenopause women in the city of Stockholm showed identical trends.

Show MeSH