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Hematocrit and mean arterial blood pressure in pre- and postmenopause women.

Vázquez BY, Vázquez MA, Intaglietta M, de Faire U, Fagrell B, Cabrales P - Vasc Health Risk Manag (2009)

Bottom Line: Premenopause women show a negative trend between parameters that is not statistically significant.It is proposed that that this MAP/Hct relationship is in part due to differences in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in blood viscosity due to changes in Hct.Comparison with a large group of postmenopause women in the city of Stockholm showed identical trends.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92037-0412, USA. borrego209@hotmail.com

ABSTRACT
The relationship between mean arterial blood pressure (MAP) and hematocrit (Hct) was studied in pre- and postmenopause women in the city of Durango, Mexico. Premenopause women show a negative trend between parameters that is not statistically significant. MAP and Hct are directly related in postmenopause women (p < 0.01). It is proposed that that this MAP/Hct relationship is in part due to differences in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in blood viscosity due to changes in Hct. Comparison with a large group of postmenopause women in the city of Stockholm showed identical trends.

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Linear regression between MAP and Hct in pre- and postmenopause women in the city of Durango, Mexico. comparison with the relation between MAP and Hct if blood viscosity is the only determinant of peripheral vascular resistance.Abbreviations: Hct, hematocrit; MAP, mean arterial blood pressure.
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f2-vhrm-5-483: Linear regression between MAP and Hct in pre- and postmenopause women in the city of Durango, Mexico. comparison with the relation between MAP and Hct if blood viscosity is the only determinant of peripheral vascular resistance.Abbreviations: Hct, hematocrit; MAP, mean arterial blood pressure.

Mentions: The relation between MAP and Hct was investigated by computing the linear dependence between these variables. MAP was linearly and significantly related to Hct with a positive slope m = 1.09 ± 0.35 mmHg/%, p < 0.01 in postmenopause women. The same analysis for premenopause women showed a negative correlation with a slope m = −0.27 ± 0.36 mmHg/%, p = 0.5 which was not statistically significant. However the difference between slopes was statistically significant, p < 0.01. This analysis is shown in Figure 2.


Hematocrit and mean arterial blood pressure in pre- and postmenopause women.

Vázquez BY, Vázquez MA, Intaglietta M, de Faire U, Fagrell B, Cabrales P - Vasc Health Risk Manag (2009)

Linear regression between MAP and Hct in pre- and postmenopause women in the city of Durango, Mexico. comparison with the relation between MAP and Hct if blood viscosity is the only determinant of peripheral vascular resistance.Abbreviations: Hct, hematocrit; MAP, mean arterial blood pressure.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2697582&req=5

f2-vhrm-5-483: Linear regression between MAP and Hct in pre- and postmenopause women in the city of Durango, Mexico. comparison with the relation between MAP and Hct if blood viscosity is the only determinant of peripheral vascular resistance.Abbreviations: Hct, hematocrit; MAP, mean arterial blood pressure.
Mentions: The relation between MAP and Hct was investigated by computing the linear dependence between these variables. MAP was linearly and significantly related to Hct with a positive slope m = 1.09 ± 0.35 mmHg/%, p < 0.01 in postmenopause women. The same analysis for premenopause women showed a negative correlation with a slope m = −0.27 ± 0.36 mmHg/%, p = 0.5 which was not statistically significant. However the difference between slopes was statistically significant, p < 0.01. This analysis is shown in Figure 2.

Bottom Line: Premenopause women show a negative trend between parameters that is not statistically significant.It is proposed that that this MAP/Hct relationship is in part due to differences in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in blood viscosity due to changes in Hct.Comparison with a large group of postmenopause women in the city of Stockholm showed identical trends.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92037-0412, USA. borrego209@hotmail.com

ABSTRACT
The relationship between mean arterial blood pressure (MAP) and hematocrit (Hct) was studied in pre- and postmenopause women in the city of Durango, Mexico. Premenopause women show a negative trend between parameters that is not statistically significant. MAP and Hct are directly related in postmenopause women (p < 0.01). It is proposed that that this MAP/Hct relationship is in part due to differences in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in blood viscosity due to changes in Hct. Comparison with a large group of postmenopause women in the city of Stockholm showed identical trends.

Show MeSH
Related in: MedlinePlus