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Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations.

Borgioli A, Viviani C, Duvina M, Brancato L, Spinelli G, Brandi ML, Tonelli P - Ther Clin Risk Manag (2009)

Bottom Line: Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia.According to our experience, the treatment of BRON-J's lesions is difficult and prolonged.For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration.

View Article: PubMed Central - PubMed

Affiliation: Department of Odontostomatology, Dental School;

ABSTRACT
Since osteonecrosis of the jaw was related to biphosphonate administration by Marx, studies showing clinical symptoms, drug and surgical therapies overwhelmed the literature. Furthermore, the literature demonstrated the correlation between chronic biphosphonate adsumption and osteonecrosis of the jaw onset. Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia. According to our experience, the treatment of BRON-J's lesions is difficult and prolonged. For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration. When pharmacologic treatments with antibiotics and local antiseptics are not able to control the development of BRON-J's complications, the clinicians should perform radical surgical treatments such as the resection of the bone involved.

No MeSH data available.


Related in: MedlinePlus

Abscessual complication of necrotic bone lesion in patient treated with Zometa® for 11 months (61 years old, male, prostatic cancer).
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f8-tcrm-5-0217: Abscessual complication of necrotic bone lesion in patient treated with Zometa® for 11 months (61 years old, male, prostatic cancer).

Mentions: The present data showed a higher incidence of BRON-J in patients treated with intravenous zolendronate and pamidronate. Clinical pictures varied from a more limited osteonecrosis areas with or without suppurative phlogosis to larger osteonecrotic areas with suppurative phlogosis, jaw fractures and extra-oral fistulae (Figure 8).


Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations.

Borgioli A, Viviani C, Duvina M, Brancato L, Spinelli G, Brandi ML, Tonelli P - Ther Clin Risk Manag (2009)

Abscessual complication of necrotic bone lesion in patient treated with Zometa® for 11 months (61 years old, male, prostatic cancer).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2697532&req=5

f8-tcrm-5-0217: Abscessual complication of necrotic bone lesion in patient treated with Zometa® for 11 months (61 years old, male, prostatic cancer).
Mentions: The present data showed a higher incidence of BRON-J in patients treated with intravenous zolendronate and pamidronate. Clinical pictures varied from a more limited osteonecrosis areas with or without suppurative phlogosis to larger osteonecrotic areas with suppurative phlogosis, jaw fractures and extra-oral fistulae (Figure 8).

Bottom Line: Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia.According to our experience, the treatment of BRON-J's lesions is difficult and prolonged.For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration.

View Article: PubMed Central - PubMed

Affiliation: Department of Odontostomatology, Dental School;

ABSTRACT
Since osteonecrosis of the jaw was related to biphosphonate administration by Marx, studies showing clinical symptoms, drug and surgical therapies overwhelmed the literature. Furthermore, the literature demonstrated the correlation between chronic biphosphonate adsumption and osteonecrosis of the jaw onset. Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia. According to our experience, the treatment of BRON-J's lesions is difficult and prolonged. For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration. When pharmacologic treatments with antibiotics and local antiseptics are not able to control the development of BRON-J's complications, the clinicians should perform radical surgical treatments such as the resection of the bone involved.

No MeSH data available.


Related in: MedlinePlus