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Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations.

Borgioli A, Viviani C, Duvina M, Brancato L, Spinelli G, Brandi ML, Tonelli P - Ther Clin Risk Manag (2009)

Bottom Line: Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia.According to our experience, the treatment of BRON-J's lesions is difficult and prolonged.For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration.

View Article: PubMed Central - PubMed

Affiliation: Department of Odontostomatology, Dental School;

ABSTRACT
Since osteonecrosis of the jaw was related to biphosphonate administration by Marx, studies showing clinical symptoms, drug and surgical therapies overwhelmed the literature. Furthermore, the literature demonstrated the correlation between chronic biphosphonate adsumption and osteonecrosis of the jaw onset. Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia. According to our experience, the treatment of BRON-J's lesions is difficult and prolonged. For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration. When pharmacologic treatments with antibiotics and local antiseptics are not able to control the development of BRON-J's complications, the clinicians should perform radical surgical treatments such as the resection of the bone involved.

No MeSH data available.


Related in: MedlinePlus

Advanced lesion of the upper jaw in patient treated with Zometa® for 12 months (69 years old, male, multiple myeloma).
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Related In: Results  -  Collection


getmorefigures.php?uid=PMC2697532&req=5

f7-tcrm-5-0217: Advanced lesion of the upper jaw in patient treated with Zometa® for 12 months (69 years old, male, multiple myeloma).

Mentions: Following the American Association of Oral and Maxillofacial Surgery's staging and treatment criteria,12 two different clinical courses have been identified: early clinical course, where a small bone sequestrum was identified (Figure 6); and late clinical course, where large neocrotic areas worsened by suppurative phlogosis were detected (Figure 7).


Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations.

Borgioli A, Viviani C, Duvina M, Brancato L, Spinelli G, Brandi ML, Tonelli P - Ther Clin Risk Manag (2009)

Advanced lesion of the upper jaw in patient treated with Zometa® for 12 months (69 years old, male, multiple myeloma).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2697532&req=5

f7-tcrm-5-0217: Advanced lesion of the upper jaw in patient treated with Zometa® for 12 months (69 years old, male, multiple myeloma).
Mentions: Following the American Association of Oral and Maxillofacial Surgery's staging and treatment criteria,12 two different clinical courses have been identified: early clinical course, where a small bone sequestrum was identified (Figure 6); and late clinical course, where large neocrotic areas worsened by suppurative phlogosis were detected (Figure 7).

Bottom Line: Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia.According to our experience, the treatment of BRON-J's lesions is difficult and prolonged.For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration.

View Article: PubMed Central - PubMed

Affiliation: Department of Odontostomatology, Dental School;

ABSTRACT
Since osteonecrosis of the jaw was related to biphosphonate administration by Marx, studies showing clinical symptoms, drug and surgical therapies overwhelmed the literature. Furthermore, the literature demonstrated the correlation between chronic biphosphonate adsumption and osteonecrosis of the jaw onset. Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia. According to our experience, the treatment of BRON-J's lesions is difficult and prolonged. For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration. When pharmacologic treatments with antibiotics and local antiseptics are not able to control the development of BRON-J's complications, the clinicians should perform radical surgical treatments such as the resection of the bone involved.

No MeSH data available.


Related in: MedlinePlus