Limits...
Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations.

Borgioli A, Viviani C, Duvina M, Brancato L, Spinelli G, Brandi ML, Tonelli P - Ther Clin Risk Manag (2009)

Bottom Line: Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia.According to our experience, the treatment of BRON-J's lesions is difficult and prolonged.For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration.

View Article: PubMed Central - PubMed

Affiliation: Department of Odontostomatology, Dental School;

ABSTRACT
Since osteonecrosis of the jaw was related to biphosphonate administration by Marx, studies showing clinical symptoms, drug and surgical therapies overwhelmed the literature. Furthermore, the literature demonstrated the correlation between chronic biphosphonate adsumption and osteonecrosis of the jaw onset. Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia. According to our experience, the treatment of BRON-J's lesions is difficult and prolonged. For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration. When pharmacologic treatments with antibiotics and local antiseptics are not able to control the development of BRON-J's complications, the clinicians should perform radical surgical treatments such as the resection of the bone involved.

No MeSH data available.


Related in: MedlinePlus

Cutaneous fistula in patient treated with Aredia® and Zometa® for 24 months (48 years old, female, breast cancer).
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2697532&req=5

f3-tcrm-5-0217: Cutaneous fistula in patient treated with Aredia® and Zometa® for 24 months (48 years old, female, breast cancer).

Mentions: This phase is characterized by purulent phlogosis, by the presence of fistulae (Figure 3), by spontaneous fractures, by compromized general physical condition with fever, and by reactive adenopathy. In this stage conservative treatments associated to prolonged antibiotic therapy can be useless because of the gravity and the extension of the process, with a radical surgery being more indicated.


Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations.

Borgioli A, Viviani C, Duvina M, Brancato L, Spinelli G, Brandi ML, Tonelli P - Ther Clin Risk Manag (2009)

Cutaneous fistula in patient treated with Aredia® and Zometa® for 24 months (48 years old, female, breast cancer).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2697532&req=5

f3-tcrm-5-0217: Cutaneous fistula in patient treated with Aredia® and Zometa® for 24 months (48 years old, female, breast cancer).
Mentions: This phase is characterized by purulent phlogosis, by the presence of fistulae (Figure 3), by spontaneous fractures, by compromized general physical condition with fever, and by reactive adenopathy. In this stage conservative treatments associated to prolonged antibiotic therapy can be useless because of the gravity and the extension of the process, with a radical surgery being more indicated.

Bottom Line: Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia.According to our experience, the treatment of BRON-J's lesions is difficult and prolonged.For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration.

View Article: PubMed Central - PubMed

Affiliation: Department of Odontostomatology, Dental School;

ABSTRACT
Since osteonecrosis of the jaw was related to biphosphonate administration by Marx, studies showing clinical symptoms, drug and surgical therapies overwhelmed the literature. Furthermore, the literature demonstrated the correlation between chronic biphosphonate adsumption and osteonecrosis of the jaw onset. Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia. According to our experience, the treatment of BRON-J's lesions is difficult and prolonged. For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration. When pharmacologic treatments with antibiotics and local antiseptics are not able to control the development of BRON-J's complications, the clinicians should perform radical surgical treatments such as the resection of the bone involved.

No MeSH data available.


Related in: MedlinePlus