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Fludarabine in the treatment of chronic lymphocytic leukemia: a review.

Ricci F, Tedeschi A, Morra E, Montillo M - Ther Clin Risk Manag (2009)

Bottom Line: FAMP as a single agent has produced superior response rates and progression-free survival than standard therapy with chlorambucil and alkylator-based regimen.Quality of response and eradication of minimal residual disease (MRD) have been reported to be associated with prolonged survival.FAMP has been widely used in non-myeloablative conditioning regimens, often combined with a variety of other cytotoxic agents, with the aim of inducing enough immunosuppression to allow successful engraftment and to exert some pretransplant anti-tumor activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology/Haematology, Niguarda Ca'Granda Hospital, Milan, Italy.

ABSTRACT
Fludarabine (FAMP) is the most effective and most extensively studied purine analog in indolent B-cell malignancies. Its use is indicated for first-and second-line treatment of B-cell chronic lymphocytic leukemia (B-CLL). FAMP as a single agent has produced superior response rates and progression-free survival than standard therapy with chlorambucil and alkylator-based regimen. Efficacy of FAMP may be increased by combining this purine analog with other chemotherapeutic and non-chemotherapeutic agents. FAMP and cyclophosphamide combination (FC) has shown promising results with higher overall response and complete response rates than FAMP in monotherapy, although no difference has been detected in survival. Quality of response and eradication of minimal residual disease (MRD) have been reported to be associated with prolonged survival. Eradication of MRD has been achieved by combining FC with mitoxantrone or monoclonal antibody including alemtuzumab or rituximab or both. FAMP has been widely used in non-myeloablative conditioning regimens, often combined with a variety of other cytotoxic agents, with the aim of inducing enough immunosuppression to allow successful engraftment and to exert some pretransplant anti-tumor activity. The current paper provides an overview of use of FAMP as a single agent or as a cornerstone of different therapeutic strategies for treatment of B-CLL patients.

No MeSH data available.


Related in: MedlinePlus

Metabolism and mechanisms of actions of fludarabine.Abbreviations: A, adenosine; dA, deoxyadenosine; F-ara-A, 9-β-D-arabinosyl-2-fluoroadenine; MP, DP, TP refer to nucleoside 5’-monophosphates, diphosphates and triphosphates, respectively.
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Related In: Results  -  Collection


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f1-tcrm-5-0187: Metabolism and mechanisms of actions of fludarabine.Abbreviations: A, adenosine; dA, deoxyadenosine; F-ara-A, 9-β-D-arabinosyl-2-fluoroadenine; MP, DP, TP refer to nucleoside 5’-monophosphates, diphosphates and triphosphates, respectively.

Mentions: The mechanism of action of FAMP is reported in Figure 1.


Fludarabine in the treatment of chronic lymphocytic leukemia: a review.

Ricci F, Tedeschi A, Morra E, Montillo M - Ther Clin Risk Manag (2009)

Metabolism and mechanisms of actions of fludarabine.Abbreviations: A, adenosine; dA, deoxyadenosine; F-ara-A, 9-β-D-arabinosyl-2-fluoroadenine; MP, DP, TP refer to nucleoside 5’-monophosphates, diphosphates and triphosphates, respectively.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2697528&req=5

f1-tcrm-5-0187: Metabolism and mechanisms of actions of fludarabine.Abbreviations: A, adenosine; dA, deoxyadenosine; F-ara-A, 9-β-D-arabinosyl-2-fluoroadenine; MP, DP, TP refer to nucleoside 5’-monophosphates, diphosphates and triphosphates, respectively.
Mentions: The mechanism of action of FAMP is reported in Figure 1.

Bottom Line: FAMP as a single agent has produced superior response rates and progression-free survival than standard therapy with chlorambucil and alkylator-based regimen.Quality of response and eradication of minimal residual disease (MRD) have been reported to be associated with prolonged survival.FAMP has been widely used in non-myeloablative conditioning regimens, often combined with a variety of other cytotoxic agents, with the aim of inducing enough immunosuppression to allow successful engraftment and to exert some pretransplant anti-tumor activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology/Haematology, Niguarda Ca'Granda Hospital, Milan, Italy.

ABSTRACT
Fludarabine (FAMP) is the most effective and most extensively studied purine analog in indolent B-cell malignancies. Its use is indicated for first-and second-line treatment of B-cell chronic lymphocytic leukemia (B-CLL). FAMP as a single agent has produced superior response rates and progression-free survival than standard therapy with chlorambucil and alkylator-based regimen. Efficacy of FAMP may be increased by combining this purine analog with other chemotherapeutic and non-chemotherapeutic agents. FAMP and cyclophosphamide combination (FC) has shown promising results with higher overall response and complete response rates than FAMP in monotherapy, although no difference has been detected in survival. Quality of response and eradication of minimal residual disease (MRD) have been reported to be associated with prolonged survival. Eradication of MRD has been achieved by combining FC with mitoxantrone or monoclonal antibody including alemtuzumab or rituximab or both. FAMP has been widely used in non-myeloablative conditioning regimens, often combined with a variety of other cytotoxic agents, with the aim of inducing enough immunosuppression to allow successful engraftment and to exert some pretransplant anti-tumor activity. The current paper provides an overview of use of FAMP as a single agent or as a cornerstone of different therapeutic strategies for treatment of B-CLL patients.

No MeSH data available.


Related in: MedlinePlus