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Failure to respond to the surface of Plasmodium falciparum infected erythrocytes predicts susceptibility to clinical malaria amongst African children.

Mackintosh CL, Mwangi T, Kinyanjui SM, Mosobo M, Pinches R, Williams TN, Newbold CI, Marsh K - Int. J. Parasitol. (2008)

Bottom Line: Following infection with Plasmodium falciparum malaria, children in endemic areas develop antibodies specific to antigens on the parasite-infected red cell surface of the infecting isolate, antibodies associated with protection against subsequent infection with that isolate.By categorising individuals according to their pre-season parasite status and antibody response to the surface of erythrocytes infected with four parasite isolates we were able to identify a group of children, those who failed to make a concomitant antibody response in the presence of an asymptomatic parasitaemia, at increased susceptibility to clinical malaria in the subsequent 6 months.Identification of this target will significantly aid understanding of naturally acquired immunity to clinical malaria amongst children in endemic areas.

View Article: PubMed Central - PubMed

Affiliation: Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi District Hospital, Kilifi, Kenya. c.mackintosh@talk21.com

ABSTRACT
Following infection with Plasmodium falciparum malaria, children in endemic areas develop antibodies specific to antigens on the parasite-infected red cell surface of the infecting isolate, antibodies associated with protection against subsequent infection with that isolate. In some circumstances induction of antibodies to heterologous parasite isolates also occurs and this has been suggested as evidence for cross-reactivity of responses against the erythrocyte surface. The role of these relatively cross-reactive antibodies in protection from clinical malaria is currently unknown. We studied the incidence of clinical malaria amongst children living on the coast of Kenya through one high transmission season. By categorising individuals according to their pre-season parasite status and antibody response to the surface of erythrocytes infected with four parasite isolates we were able to identify a group of children, those who failed to make a concomitant antibody response in the presence of an asymptomatic parasitaemia, at increased susceptibility to clinical malaria in the subsequent 6 months. The fact that this susceptible group was identified regardless of the parasite isolate tested infers a cross-reactive or conserved target is present on the surface of infected erythrocytes. Identification of this target will significantly aid understanding of naturally acquired immunity to clinical malaria amongst children in endemic areas.

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Responses to Plasmodium falciparum isolate A4U. The proportion of individuals in each age category is shown, with upper 95% confidence interval, scoring positive for antibody recognition of parasite line A4U. Positivity was scored as defined in the text. The dark grey bars represent individuals with no microscopically detectable parasitaemia at the time of the cross-sectional survey and the light grey bars represent individuals with parasites detected at that time.
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fig1: Responses to Plasmodium falciparum isolate A4U. The proportion of individuals in each age category is shown, with upper 95% confidence interval, scoring positive for antibody recognition of parasite line A4U. Positivity was scored as defined in the text. The dark grey bars represent individuals with no microscopically detectable parasitaemia at the time of the cross-sectional survey and the light grey bars represent individuals with parasites detected at that time.

Mentions: Antibody responses to A4U increased significantly with age in individuals who were parasite-positive or parasite-negative at cross-sectional survey (Fig. 1). Responses increased similarly with age for the other parasite isolates used in this study (data not shown, see Supplementary Fig. S1 for details).


Failure to respond to the surface of Plasmodium falciparum infected erythrocytes predicts susceptibility to clinical malaria amongst African children.

Mackintosh CL, Mwangi T, Kinyanjui SM, Mosobo M, Pinches R, Williams TN, Newbold CI, Marsh K - Int. J. Parasitol. (2008)

Responses to Plasmodium falciparum isolate A4U. The proportion of individuals in each age category is shown, with upper 95% confidence interval, scoring positive for antibody recognition of parasite line A4U. Positivity was scored as defined in the text. The dark grey bars represent individuals with no microscopically detectable parasitaemia at the time of the cross-sectional survey and the light grey bars represent individuals with parasites detected at that time.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2697313&req=5

fig1: Responses to Plasmodium falciparum isolate A4U. The proportion of individuals in each age category is shown, with upper 95% confidence interval, scoring positive for antibody recognition of parasite line A4U. Positivity was scored as defined in the text. The dark grey bars represent individuals with no microscopically detectable parasitaemia at the time of the cross-sectional survey and the light grey bars represent individuals with parasites detected at that time.
Mentions: Antibody responses to A4U increased significantly with age in individuals who were parasite-positive or parasite-negative at cross-sectional survey (Fig. 1). Responses increased similarly with age for the other parasite isolates used in this study (data not shown, see Supplementary Fig. S1 for details).

Bottom Line: Following infection with Plasmodium falciparum malaria, children in endemic areas develop antibodies specific to antigens on the parasite-infected red cell surface of the infecting isolate, antibodies associated with protection against subsequent infection with that isolate.By categorising individuals according to their pre-season parasite status and antibody response to the surface of erythrocytes infected with four parasite isolates we were able to identify a group of children, those who failed to make a concomitant antibody response in the presence of an asymptomatic parasitaemia, at increased susceptibility to clinical malaria in the subsequent 6 months.Identification of this target will significantly aid understanding of naturally acquired immunity to clinical malaria amongst children in endemic areas.

View Article: PubMed Central - PubMed

Affiliation: Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi District Hospital, Kilifi, Kenya. c.mackintosh@talk21.com

ABSTRACT
Following infection with Plasmodium falciparum malaria, children in endemic areas develop antibodies specific to antigens on the parasite-infected red cell surface of the infecting isolate, antibodies associated with protection against subsequent infection with that isolate. In some circumstances induction of antibodies to heterologous parasite isolates also occurs and this has been suggested as evidence for cross-reactivity of responses against the erythrocyte surface. The role of these relatively cross-reactive antibodies in protection from clinical malaria is currently unknown. We studied the incidence of clinical malaria amongst children living on the coast of Kenya through one high transmission season. By categorising individuals according to their pre-season parasite status and antibody response to the surface of erythrocytes infected with four parasite isolates we were able to identify a group of children, those who failed to make a concomitant antibody response in the presence of an asymptomatic parasitaemia, at increased susceptibility to clinical malaria in the subsequent 6 months. The fact that this susceptible group was identified regardless of the parasite isolate tested infers a cross-reactive or conserved target is present on the surface of infected erythrocytes. Identification of this target will significantly aid understanding of naturally acquired immunity to clinical malaria amongst children in endemic areas.

Show MeSH
Related in: MedlinePlus