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The Pavlovian power of palatable food: lessons for weight-loss adherence from a new rodent model of cue-induced overeating.

Boggiano MM, Dorsey JR, Thomas JM, Murdaugh DL - Int J Obes (Lond) (2009)

Bottom Line: This effect occurred using various cues (for example, different types of bedding or wallpaper).The effect was strengthened by priming with a morsel of PF (P<0.001) and was unaffected by baseline differences in propensity to binge on PF.This model should help identify the reflex-like biology that sabotages attempts to adhere to healthy reduced calorie regimens and call greater attention to the cue-factor in the treatment of binge eating and obesity.

View Article: PubMed Central - PubMed

Affiliation: Behavioral Neuroscience Division, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35394-1170, USA. boggiano@uab.edu

ABSTRACT

Objective: Relapsing to overeating is a stubborn problem in obesity treatment. We tested the hypothesis that context cues surrounding palatable food (PF) intake have the power to disrupt caloric regulation even of less PF. Context cues are non-food cues that are in the environment where PF is habitually eaten.

Design: Rats were conditioned to associate intake of Oreo cookies as the PF to cages with distinct context cues that differed from cues in cages where they were only given chow. PF naturally stimulated greater caloric intake. The rats were then tested in the PF cage with only chow available to determine whether the PF-paired cues, alone, could elicit overeating of plain chow.

Subjects: Non-food-deprived female Sprague-Dawley rats.

Measurements: Intake of plain chow under PF-paired cues vs chow-paired cues was compared. This was also measured in tests that included a morsel of PF as a priming stimulus. We also controlled for any effect of binge-prone vs binge-resistant status to predict cued-overeating.

Results: Rats consumed significantly more chow when exposed to context cues paired earlier with PF than with chow (P<0.01). This effect occurred using various cues (for example, different types of bedding or wallpaper). The effect was strengthened by priming with a morsel of PF (P<0.001) and was unaffected by baseline differences in propensity to binge on PF.

Conclusion: Context-cues associated with PF intake can drive overeating even of a less PF and abolish the ability of rats to compensate for the calories of a PF primer. Just as drug-associated context cues can reinstate drug-addiction relapse, PF-paired cues may trigger overeating relapses linked to weight regain and obesity. This model should help identify the reflex-like biology that sabotages attempts to adhere to healthy reduced calorie regimens and call greater attention to the cue-factor in the treatment of binge eating and obesity.

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Related in: MedlinePlus

The mean amount of chow and Oreo cookie kcals ingested in the first 4 hrs of dark across four feeding tests used to determine binge-eating prone (BEP) from binge-eating resistant (BER) rats. BEPs ate more of the highly palatable food (cookies) than did BERs; **p<0.01 (and at each feeding test, **p<0.01 per test).
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Figure 1: The mean amount of chow and Oreo cookie kcals ingested in the first 4 hrs of dark across four feeding tests used to determine binge-eating prone (BEP) from binge-eating resistant (BER) rats. BEPs ate more of the highly palatable food (cookies) than did BERs; **p<0.01 (and at each feeding test, **p<0.01 per test).

Mentions: The average median split value of PF intake in N = 50 rats was 35 kcals/4hrs. Rats assigned BEP status consistently ate a minimum mean of 30% more PF than BERs during the “cookie + chow feeding tests” used to assign BEP/BER status (Figure 1; p<0.01). BEPs were confirmed to not simply be “big” eaters because tests where only chow was provided in the cage confirmed that they ate no more chow than did BERs (data taken a week after the 4 “cookie + chow feeding tests”: BEP: 50.7 ± 2.5 vs. BER: 50.1 ± 2.6 chow kcals/4hrs, ns; not shown). Body weights recorded after the feeding tests confirmed no difference between groups (BER: 220.7 ± 3.2 vs. BEPs: 226.7 ± 3.8 g, ns; not shown). During the tests, the middle-most PF-eating group always consumed an amount of PF between that of BEPs and BERs (not shown).


The Pavlovian power of palatable food: lessons for weight-loss adherence from a new rodent model of cue-induced overeating.

Boggiano MM, Dorsey JR, Thomas JM, Murdaugh DL - Int J Obes (Lond) (2009)

The mean amount of chow and Oreo cookie kcals ingested in the first 4 hrs of dark across four feeding tests used to determine binge-eating prone (BEP) from binge-eating resistant (BER) rats. BEPs ate more of the highly palatable food (cookies) than did BERs; **p<0.01 (and at each feeding test, **p<0.01 per test).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2697275&req=5

Figure 1: The mean amount of chow and Oreo cookie kcals ingested in the first 4 hrs of dark across four feeding tests used to determine binge-eating prone (BEP) from binge-eating resistant (BER) rats. BEPs ate more of the highly palatable food (cookies) than did BERs; **p<0.01 (and at each feeding test, **p<0.01 per test).
Mentions: The average median split value of PF intake in N = 50 rats was 35 kcals/4hrs. Rats assigned BEP status consistently ate a minimum mean of 30% more PF than BERs during the “cookie + chow feeding tests” used to assign BEP/BER status (Figure 1; p<0.01). BEPs were confirmed to not simply be “big” eaters because tests where only chow was provided in the cage confirmed that they ate no more chow than did BERs (data taken a week after the 4 “cookie + chow feeding tests”: BEP: 50.7 ± 2.5 vs. BER: 50.1 ± 2.6 chow kcals/4hrs, ns; not shown). Body weights recorded after the feeding tests confirmed no difference between groups (BER: 220.7 ± 3.2 vs. BEPs: 226.7 ± 3.8 g, ns; not shown). During the tests, the middle-most PF-eating group always consumed an amount of PF between that of BEPs and BERs (not shown).

Bottom Line: This effect occurred using various cues (for example, different types of bedding or wallpaper).The effect was strengthened by priming with a morsel of PF (P<0.001) and was unaffected by baseline differences in propensity to binge on PF.This model should help identify the reflex-like biology that sabotages attempts to adhere to healthy reduced calorie regimens and call greater attention to the cue-factor in the treatment of binge eating and obesity.

View Article: PubMed Central - PubMed

Affiliation: Behavioral Neuroscience Division, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35394-1170, USA. boggiano@uab.edu

ABSTRACT

Objective: Relapsing to overeating is a stubborn problem in obesity treatment. We tested the hypothesis that context cues surrounding palatable food (PF) intake have the power to disrupt caloric regulation even of less PF. Context cues are non-food cues that are in the environment where PF is habitually eaten.

Design: Rats were conditioned to associate intake of Oreo cookies as the PF to cages with distinct context cues that differed from cues in cages where they were only given chow. PF naturally stimulated greater caloric intake. The rats were then tested in the PF cage with only chow available to determine whether the PF-paired cues, alone, could elicit overeating of plain chow.

Subjects: Non-food-deprived female Sprague-Dawley rats.

Measurements: Intake of plain chow under PF-paired cues vs chow-paired cues was compared. This was also measured in tests that included a morsel of PF as a priming stimulus. We also controlled for any effect of binge-prone vs binge-resistant status to predict cued-overeating.

Results: Rats consumed significantly more chow when exposed to context cues paired earlier with PF than with chow (P<0.01). This effect occurred using various cues (for example, different types of bedding or wallpaper). The effect was strengthened by priming with a morsel of PF (P<0.001) and was unaffected by baseline differences in propensity to binge on PF.

Conclusion: Context-cues associated with PF intake can drive overeating even of a less PF and abolish the ability of rats to compensate for the calories of a PF primer. Just as drug-associated context cues can reinstate drug-addiction relapse, PF-paired cues may trigger overeating relapses linked to weight regain and obesity. This model should help identify the reflex-like biology that sabotages attempts to adhere to healthy reduced calorie regimens and call greater attention to the cue-factor in the treatment of binge eating and obesity.

Show MeSH
Related in: MedlinePlus