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Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue.

Dursun H, Bilici M, Albayrak F, Ozturk C, Saglam MB, Alp HH, Suleyman H - BMC Gastroenterol (2009)

Bottom Line: The 25, 50, 100 and 200 mg/kg doses of fluvoxamine exerted antiulcer effects of 48.5, 67.5, 82.1 and 96.1%, respectively, compared to the control rat group.Ranitidine showed an 86.5% antiulcer effect.We conclude that fluvoxamine has antiulcer effects, and that these occur by a mechanism that involves activation of antioxidant parameters and inhibition of some toxic oxidant parameters.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pharmacology, Ataturk University, Faculty of Medicine, Erzurum, Turkey. hadursun@hotmail.com

ABSTRACT

Background: Although many drugs are available for the treatment of gastric ulcers, often these drugs are ineffective. Many antidepressant drugs have been shown to have antiulcer activity in various models of experimental ulcer. One such drug, the antidepressant mirtazapine, has been reported to have an antiulcer effect that involves an increase in antioxidant, and a decrease in oxidant, parameters. To date, however, there is no information available regarding the antiulcer activity for a similar antidepressant, fluvoxamine. This study aimed to investigate the antiulcer effects of fluvoxamine and to determine its relationship with antioxidants.

Methods: Groups of rats fasted for 24 h received fluvoxamine (25, 50, 100 and 200 mg/kg), ranitidine (50 mg/kg) or distilled water by oral gavage. Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent. Six hours after ulcer induction, the stomachs of the rats were excised and an ulcer index determined. Separate groups of rats were treated with the same doses of fluvoxamine and ranitidine, but not with indomethacin, to test effects of these drugs alone on biochemical parameters. The stomachs were evaluated biochemically to determine oxidant and antioxidant parameters. We used one-way ANOVA and least significant difference (LSD) options for data analysis.

Results: The 25, 50, 100 and 200 mg/kg doses of fluvoxamine exerted antiulcer effects of 48.5, 67.5, 82.1 and 96.1%, respectively, compared to the control rat group. Ranitidine showed an 86.5% antiulcer effect. No differences were observed in the absence of indomethacin treatment for any dose of fluvoxamine or for ranitidine. The levels of antioxidant parameters, total glutathione and nitric oxide, were increased in all fluvoxamine groups and in the ranitidine group when compared with the indomethacin-only group. In addition, fluvoxamine and ranitidine decreased the levels of the oxidant parameters, myeloperoxidase and malondialdeyhyde, in the stomach tissues of the rats when compared to indomethacin group.

Conclusion: We conclude that fluvoxamine has antiulcer effects, and that these occur by a mechanism that involves activation of antioxidant parameters and inhibition of some toxic oxidant parameters.

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Related in: MedlinePlus

Effects of fluvoxamine (FLU)+indomethacin (IND), ranitidine (RAN)+indomethacin (IND) and alone indomethacin (IND) on MPO levels in the stomach tissues of rats. *Significant at p < 0.05 when compared to control.
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Figure 3: Effects of fluvoxamine (FLU)+indomethacin (IND), ranitidine (RAN)+indomethacin (IND) and alone indomethacin (IND) on MPO levels in the stomach tissues of rats. *Significant at p < 0.05 when compared to control.

Mentions: All doses of fluvoxamine and ranitidine significantly decreased the amount of GSH in stomach tissues when compared to healthy intact rats, when administered alone However, a 25 mg/kg dose of fluvoxamine did not affect the levels of other parameters that we measured (MDA, NO and MPO) when compared to healthy intact rats (Table 2). At doses of 50, 100 and 200 mg/kg fluvoxamine significantly decreased the levels of MDA and MPO and increased the level of NO in stomach tissue when compared to intact healthy rat group. Similar changes were observed in tissues from ranitidine-treated rats. Indomethacin application significantly decreased the levels of antioxidant parameters, GSH and NO, and significantly increased the levels of oxidant parameters, MPO and MDA. All doses of fluvoxamine and ranitidine which were co-administrated with indomethacin reversed the negative effects of indomethacin on stomach tissue (Figures 1, 2, 3, 4).


Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue.

Dursun H, Bilici M, Albayrak F, Ozturk C, Saglam MB, Alp HH, Suleyman H - BMC Gastroenterol (2009)

Effects of fluvoxamine (FLU)+indomethacin (IND), ranitidine (RAN)+indomethacin (IND) and alone indomethacin (IND) on MPO levels in the stomach tissues of rats. *Significant at p < 0.05 when compared to control.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2693117&req=5

Figure 3: Effects of fluvoxamine (FLU)+indomethacin (IND), ranitidine (RAN)+indomethacin (IND) and alone indomethacin (IND) on MPO levels in the stomach tissues of rats. *Significant at p < 0.05 when compared to control.
Mentions: All doses of fluvoxamine and ranitidine significantly decreased the amount of GSH in stomach tissues when compared to healthy intact rats, when administered alone However, a 25 mg/kg dose of fluvoxamine did not affect the levels of other parameters that we measured (MDA, NO and MPO) when compared to healthy intact rats (Table 2). At doses of 50, 100 and 200 mg/kg fluvoxamine significantly decreased the levels of MDA and MPO and increased the level of NO in stomach tissue when compared to intact healthy rat group. Similar changes were observed in tissues from ranitidine-treated rats. Indomethacin application significantly decreased the levels of antioxidant parameters, GSH and NO, and significantly increased the levels of oxidant parameters, MPO and MDA. All doses of fluvoxamine and ranitidine which were co-administrated with indomethacin reversed the negative effects of indomethacin on stomach tissue (Figures 1, 2, 3, 4).

Bottom Line: The 25, 50, 100 and 200 mg/kg doses of fluvoxamine exerted antiulcer effects of 48.5, 67.5, 82.1 and 96.1%, respectively, compared to the control rat group.Ranitidine showed an 86.5% antiulcer effect.We conclude that fluvoxamine has antiulcer effects, and that these occur by a mechanism that involves activation of antioxidant parameters and inhibition of some toxic oxidant parameters.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pharmacology, Ataturk University, Faculty of Medicine, Erzurum, Turkey. hadursun@hotmail.com

ABSTRACT

Background: Although many drugs are available for the treatment of gastric ulcers, often these drugs are ineffective. Many antidepressant drugs have been shown to have antiulcer activity in various models of experimental ulcer. One such drug, the antidepressant mirtazapine, has been reported to have an antiulcer effect that involves an increase in antioxidant, and a decrease in oxidant, parameters. To date, however, there is no information available regarding the antiulcer activity for a similar antidepressant, fluvoxamine. This study aimed to investigate the antiulcer effects of fluvoxamine and to determine its relationship with antioxidants.

Methods: Groups of rats fasted for 24 h received fluvoxamine (25, 50, 100 and 200 mg/kg), ranitidine (50 mg/kg) or distilled water by oral gavage. Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent. Six hours after ulcer induction, the stomachs of the rats were excised and an ulcer index determined. Separate groups of rats were treated with the same doses of fluvoxamine and ranitidine, but not with indomethacin, to test effects of these drugs alone on biochemical parameters. The stomachs were evaluated biochemically to determine oxidant and antioxidant parameters. We used one-way ANOVA and least significant difference (LSD) options for data analysis.

Results: The 25, 50, 100 and 200 mg/kg doses of fluvoxamine exerted antiulcer effects of 48.5, 67.5, 82.1 and 96.1%, respectively, compared to the control rat group. Ranitidine showed an 86.5% antiulcer effect. No differences were observed in the absence of indomethacin treatment for any dose of fluvoxamine or for ranitidine. The levels of antioxidant parameters, total glutathione and nitric oxide, were increased in all fluvoxamine groups and in the ranitidine group when compared with the indomethacin-only group. In addition, fluvoxamine and ranitidine decreased the levels of the oxidant parameters, myeloperoxidase and malondialdeyhyde, in the stomach tissues of the rats when compared to indomethacin group.

Conclusion: We conclude that fluvoxamine has antiulcer effects, and that these occur by a mechanism that involves activation of antioxidant parameters and inhibition of some toxic oxidant parameters.

Show MeSH
Related in: MedlinePlus