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Correlation of histopathological diagnosis with habits and clinical findings in oral submucous fibrosis.

Pandya S, Chaudhary AK, Singh M, Singh M, Mehrotra R - Head Neck Oncol (2009)

Bottom Line: The buccal mucosa was found to be the most commonly involved site.In this study, an increase in histopathological grading was found with severity and duration of addiction habit.However no significant correlation was found between clinical staging and histopathological grading.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India. shrutigentech@gmail.com

ABSTRACT

Background: Oral submucous fibrosis is a common oral health problem in India. This study was conducted to correlate the histopathological diagnosis with habits and clinical findings in patients suffering from oral submucous fibrosis (OSF).

Methods: Patients suffering from oral submucous fibrosis from the Departments of Otorhinolaryngology and Pathology, Moti Lal Nehru Medical College, Allahabad, India were studied from 2004-2008. Detailed information was gathered in a pretested proforma. Emphasis was given to the various addictions, clinical findings and histological examination was done.

Results: Two hundred and thirty nine patients were studied, yielding a male to female ratio of 6.8:1. Maximum patients were in the 21-30 years age group with a marked male predominance. Of these, 197 (82.4%) patients chewed areca nut/dohra, 14 (5.8%) were smokers and 2 (0.8%) patients were habituated to alcohol. 89 (37.2%) patients reported difficulty in opening of the mouth (trismus). 51 (57.4%) patients were found to have stage II (2-3 cm) trismus while rest had stage I and III. The buccal mucosa was found to be the most commonly involved site. On the basis of histopathological examination, 52 (21.7%) were classified as OSF grade I, 75 (31.3%) patients as grade II and 112 (46.8%) had grade III disease.

Conclusion: The widespread habit of chewing dohra/paan masala is a major risk factor of OSF, especially in the younger age group. In this study, an increase in histopathological grading was found with severity and duration of addiction habit. However no significant correlation was found between clinical staging and histopathological grading.

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Oral Mucosa showing OSF grade III showing thinning of the epidermis, hyalinized collagen and lymphocytic infiltration. (H and E × 400).
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Figure 5: Oral Mucosa showing OSF grade III showing thinning of the epidermis, hyalinized collagen and lymphocytic infiltration. (H and E × 400).

Mentions: One hundred and twelve (46.8%) patients had histopathological grade III disease and of these 60 (53.5%) chewed paan masala/dohra, 23 (20.4%) were habituated to gutka, 20 (18%) consumed betel quid with areca nut and tobacco, 3(2.7%) were smokers, 2 (1.8%) both chewed and smoked, 2 (1.8%) were addicted to alcohol and smoking, 1(0.9%) consumed alcohol and chewed tobacco and 1(0.9%) was addicted to alcohol. Majority of patients of this group consumed tobacco products for 8–10 years or more with a frequency of 6–10 times per day [Table 3, Figure 5].


Correlation of histopathological diagnosis with habits and clinical findings in oral submucous fibrosis.

Pandya S, Chaudhary AK, Singh M, Singh M, Mehrotra R - Head Neck Oncol (2009)

Oral Mucosa showing OSF grade III showing thinning of the epidermis, hyalinized collagen and lymphocytic infiltration. (H and E × 400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2691735&req=5

Figure 5: Oral Mucosa showing OSF grade III showing thinning of the epidermis, hyalinized collagen and lymphocytic infiltration. (H and E × 400).
Mentions: One hundred and twelve (46.8%) patients had histopathological grade III disease and of these 60 (53.5%) chewed paan masala/dohra, 23 (20.4%) were habituated to gutka, 20 (18%) consumed betel quid with areca nut and tobacco, 3(2.7%) were smokers, 2 (1.8%) both chewed and smoked, 2 (1.8%) were addicted to alcohol and smoking, 1(0.9%) consumed alcohol and chewed tobacco and 1(0.9%) was addicted to alcohol. Majority of patients of this group consumed tobacco products for 8–10 years or more with a frequency of 6–10 times per day [Table 3, Figure 5].

Bottom Line: The buccal mucosa was found to be the most commonly involved site.In this study, an increase in histopathological grading was found with severity and duration of addiction habit.However no significant correlation was found between clinical staging and histopathological grading.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India. shrutigentech@gmail.com

ABSTRACT

Background: Oral submucous fibrosis is a common oral health problem in India. This study was conducted to correlate the histopathological diagnosis with habits and clinical findings in patients suffering from oral submucous fibrosis (OSF).

Methods: Patients suffering from oral submucous fibrosis from the Departments of Otorhinolaryngology and Pathology, Moti Lal Nehru Medical College, Allahabad, India were studied from 2004-2008. Detailed information was gathered in a pretested proforma. Emphasis was given to the various addictions, clinical findings and histological examination was done.

Results: Two hundred and thirty nine patients were studied, yielding a male to female ratio of 6.8:1. Maximum patients were in the 21-30 years age group with a marked male predominance. Of these, 197 (82.4%) patients chewed areca nut/dohra, 14 (5.8%) were smokers and 2 (0.8%) patients were habituated to alcohol. 89 (37.2%) patients reported difficulty in opening of the mouth (trismus). 51 (57.4%) patients were found to have stage II (2-3 cm) trismus while rest had stage I and III. The buccal mucosa was found to be the most commonly involved site. On the basis of histopathological examination, 52 (21.7%) were classified as OSF grade I, 75 (31.3%) patients as grade II and 112 (46.8%) had grade III disease.

Conclusion: The widespread habit of chewing dohra/paan masala is a major risk factor of OSF, especially in the younger age group. In this study, an increase in histopathological grading was found with severity and duration of addiction habit. However no significant correlation was found between clinical staging and histopathological grading.

Show MeSH
Related in: MedlinePlus