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Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy.

Crohns M, Saarelainen S, Kankaanranta H, Moilanen E, Alho H, Kellokumpu-Lehtinen P - Free Radic. Res. (2009)

Bottom Line: LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p=0.016, p<0.001 and p=0.027, respectively), but BAL fluid oxidative stress markers were similar.RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p=0.044, p=0.034 and p=0.004, respectively) 3 months after RT.RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, University of Tampere, Tampere, Finland. macro1@sci.fi

ABSTRACT
To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and after RT for LC. LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p=0.016, p<0.001 and p=0.027, respectively), but BAL fluid oxidative stress markers were similar. RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p=0.044, p=0.034 and p=0.004, respectively) 3 months after RT. High urate at baseline may compensate against the oxidative stress caused by LC. RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.

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Related in: MedlinePlus

Scatterplots and regression lines for associations between patients plasma ascorbate (μmol/L) vs BAL thiols (μmol/L), Spearman R = −0.377, p = 0.052 and plasma thiols (μmol/L), R = −0.446, p = 0.008. One outlier with plasma ascorbate 60.5 vs BAL thiols 11.9 is outside the figure.
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fig4: Scatterplots and regression lines for associations between patients plasma ascorbate (μmol/L) vs BAL thiols (μmol/L), Spearman R = −0.377, p = 0.052 and plasma thiols (μmol/L), R = −0.446, p = 0.008. One outlier with plasma ascorbate 60.5 vs BAL thiols 11.9 is outside the figure.

Mentions: There were significant positive correlations between BAL ascorbic acid and plasma ascorbic acid (R = 0.342, p = 0.005), BAL thiols and both serum urate (R = 0.481, p = 0.001) and serum alpha-tocopherol (R = 0.714, p = 0.031) and a negative correlation between plasma ascorbic acid and both plasma and BAL thiols at baseline (R = −0.446, p = 0.008 and R = −0.377, p = 0.052, respectively) (Figure 4).


Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy.

Crohns M, Saarelainen S, Kankaanranta H, Moilanen E, Alho H, Kellokumpu-Lehtinen P - Free Radic. Res. (2009)

Scatterplots and regression lines for associations between patients plasma ascorbate (μmol/L) vs BAL thiols (μmol/L), Spearman R = −0.377, p = 0.052 and plasma thiols (μmol/L), R = −0.446, p = 0.008. One outlier with plasma ascorbate 60.5 vs BAL thiols 11.9 is outside the figure.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2691182&req=5

fig4: Scatterplots and regression lines for associations between patients plasma ascorbate (μmol/L) vs BAL thiols (μmol/L), Spearman R = −0.377, p = 0.052 and plasma thiols (μmol/L), R = −0.446, p = 0.008. One outlier with plasma ascorbate 60.5 vs BAL thiols 11.9 is outside the figure.
Mentions: There were significant positive correlations between BAL ascorbic acid and plasma ascorbic acid (R = 0.342, p = 0.005), BAL thiols and both serum urate (R = 0.481, p = 0.001) and serum alpha-tocopherol (R = 0.714, p = 0.031) and a negative correlation between plasma ascorbic acid and both plasma and BAL thiols at baseline (R = −0.446, p = 0.008 and R = −0.377, p = 0.052, respectively) (Figure 4).

Bottom Line: LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p=0.016, p<0.001 and p=0.027, respectively), but BAL fluid oxidative stress markers were similar.RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p=0.044, p=0.034 and p=0.004, respectively) 3 months after RT.RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, University of Tampere, Tampere, Finland. macro1@sci.fi

ABSTRACT
To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and after RT for LC. LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p=0.016, p<0.001 and p=0.027, respectively), but BAL fluid oxidative stress markers were similar. RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p=0.044, p=0.034 and p=0.004, respectively) 3 months after RT. High urate at baseline may compensate against the oxidative stress caused by LC. RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.

Show MeSH
Related in: MedlinePlus