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Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy.

Crohns M, Saarelainen S, Kankaanranta H, Moilanen E, Alho H, Kellokumpu-Lehtinen P - Free Radic. Res. (2009)

Bottom Line: LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p=0.016, p<0.001 and p=0.027, respectively), but BAL fluid oxidative stress markers were similar.RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p=0.044, p=0.034 and p=0.004, respectively) 3 months after RT.RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, University of Tampere, Tampere, Finland. macro1@sci.fi

ABSTRACT
To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and after RT for LC. LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p=0.016, p<0.001 and p=0.027, respectively), but BAL fluid oxidative stress markers were similar. RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p=0.044, p=0.034 and p=0.004, respectively) 3 months after RT. High urate at baseline may compensate against the oxidative stress caused by LC. RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.

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Related in: MedlinePlus

Kaplan-Meier survival curves for patients with baseline BAL thiols >4.34 μmol/L (n = 14) vs patients with BAL thiols <4.34 μmol/L n = 14). Log-rank test p = 0.051.
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fig3: Kaplan-Meier survival curves for patients with baseline BAL thiols >4.34 μmol/L (n = 14) vs patients with BAL thiols <4.34 μmol/L n = 14). Log-rank test p = 0.051.

Mentions: The planned follow-up time of the patient group was 72 months. None of the patients was lost to follow-up. At the end of the study, one patient (3%) was alive and 35 (97%) had died. The median survival time of the patients was 9.9 months (95% CI 5.4–14.4 months). The survival time tended to be longer when the patient's baseline BAL thiol levels were above the median concentration of 4.34 μmol/L (9.9 months vs 6.1. months, p = 0.051) (Figure 3).


Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy.

Crohns M, Saarelainen S, Kankaanranta H, Moilanen E, Alho H, Kellokumpu-Lehtinen P - Free Radic. Res. (2009)

Kaplan-Meier survival curves for patients with baseline BAL thiols >4.34 μmol/L (n = 14) vs patients with BAL thiols <4.34 μmol/L n = 14). Log-rank test p = 0.051.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2691182&req=5

fig3: Kaplan-Meier survival curves for patients with baseline BAL thiols >4.34 μmol/L (n = 14) vs patients with BAL thiols <4.34 μmol/L n = 14). Log-rank test p = 0.051.
Mentions: The planned follow-up time of the patient group was 72 months. None of the patients was lost to follow-up. At the end of the study, one patient (3%) was alive and 35 (97%) had died. The median survival time of the patients was 9.9 months (95% CI 5.4–14.4 months). The survival time tended to be longer when the patient's baseline BAL thiol levels were above the median concentration of 4.34 μmol/L (9.9 months vs 6.1. months, p = 0.051) (Figure 3).

Bottom Line: LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p=0.016, p<0.001 and p=0.027, respectively), but BAL fluid oxidative stress markers were similar.RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p=0.044, p=0.034 and p=0.004, respectively) 3 months after RT.RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, University of Tampere, Tampere, Finland. macro1@sci.fi

ABSTRACT
To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and after RT for LC. LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p=0.016, p<0.001 and p=0.027, respectively), but BAL fluid oxidative stress markers were similar. RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p=0.044, p=0.034 and p=0.004, respectively) 3 months after RT. High urate at baseline may compensate against the oxidative stress caused by LC. RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.

Show MeSH
Related in: MedlinePlus