Limits...
Cutaneous skull metastasis from uterine leiomyosarcoma: a case report.

Barbetakis N, Paliouras D, Asteriou C, Samanidis G, Kleontas A, Anestakis D, Kaplanis K, Tsilikas C - World J Surg Oncol (2009)

Bottom Line: Cutaneous metastases in the facial region occur in less than 0.5% of patients with metastatic cancer.A 52-year-old woman who admitted with a lung and a skull skin nodule is presented.Biopsy and immunohistochemistry are essential for correct diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Thoracic Surgery Department, Theagenio Cancer Hospital, A. Simeonidi 2, Thessaloniki, 54007, Greece. nibarbet@yahoo.gr

ABSTRACT

Background: Cutaneous metastases in the facial region occur in less than 0.5% of patients with metastatic cancer.

Case presentation: A 52-year-old woman who admitted with a lung and a skull skin nodule is presented. She had a known diagnosis of uterine leiomyosarcoma following an extended total hysterectomy two years ago. Excision biopsy of both nodules revealed metastatic disease.

Conclusion: The appearance of a cutaneous nodule in a patient with a history of uterine leiomyosarcoma might indicate a metastatic tumor lesion. Biopsy and immunohistochemistry are essential for correct diagnosis.

Show MeSH

Related in: MedlinePlus

Pathology of the excised cutaneous nodule consistent with metastatic uterine leiomyosarcoma (cellular eosinophilic spindle cell tumor with nuclear atypia and mitosis) (HE ×40 and ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2683835&req=5

Figure 4: Pathology of the excised cutaneous nodule consistent with metastatic uterine leiomyosarcoma (cellular eosinophilic spindle cell tumor with nuclear atypia and mitosis) (HE ×40 and ×200).

Mentions: The patient remained asymptomatic for 2 years postoperatively. During regular follow up, computed tomography demonstrated a suspicious lung lesion. Clinical examination also revealed a nodule measuring 4 × 4 cm on the skull skin of the left temporal lobe (Figures 1, 2). Therefore under general anesthesia, she underwent video-assisted thoracic surgery for the pulmonary nodule (wedge resection) and excision biopsy of the cutaneous lesion at the same time. Both of them were diagnosed as metastases from uterine leiomyosarcoma. The excised skin nodule revealed a proliferation of atypical spindle cells with a woven, palisading and rosette-forming pattern surrounded by fibrocollagenous tissue, with a high mitotic ratio (Figures 3, 4). Further immunohistochemical staining was positive for desmin and vimentin and this confirmed the diagnosis. The patient was referred for chemotherapy and 8 months later is still alive but with multiple lung metastases.


Cutaneous skull metastasis from uterine leiomyosarcoma: a case report.

Barbetakis N, Paliouras D, Asteriou C, Samanidis G, Kleontas A, Anestakis D, Kaplanis K, Tsilikas C - World J Surg Oncol (2009)

Pathology of the excised cutaneous nodule consistent with metastatic uterine leiomyosarcoma (cellular eosinophilic spindle cell tumor with nuclear atypia and mitosis) (HE ×40 and ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2683835&req=5

Figure 4: Pathology of the excised cutaneous nodule consistent with metastatic uterine leiomyosarcoma (cellular eosinophilic spindle cell tumor with nuclear atypia and mitosis) (HE ×40 and ×200).
Mentions: The patient remained asymptomatic for 2 years postoperatively. During regular follow up, computed tomography demonstrated a suspicious lung lesion. Clinical examination also revealed a nodule measuring 4 × 4 cm on the skull skin of the left temporal lobe (Figures 1, 2). Therefore under general anesthesia, she underwent video-assisted thoracic surgery for the pulmonary nodule (wedge resection) and excision biopsy of the cutaneous lesion at the same time. Both of them were diagnosed as metastases from uterine leiomyosarcoma. The excised skin nodule revealed a proliferation of atypical spindle cells with a woven, palisading and rosette-forming pattern surrounded by fibrocollagenous tissue, with a high mitotic ratio (Figures 3, 4). Further immunohistochemical staining was positive for desmin and vimentin and this confirmed the diagnosis. The patient was referred for chemotherapy and 8 months later is still alive but with multiple lung metastases.

Bottom Line: Cutaneous metastases in the facial region occur in less than 0.5% of patients with metastatic cancer.A 52-year-old woman who admitted with a lung and a skull skin nodule is presented.Biopsy and immunohistochemistry are essential for correct diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Thoracic Surgery Department, Theagenio Cancer Hospital, A. Simeonidi 2, Thessaloniki, 54007, Greece. nibarbet@yahoo.gr

ABSTRACT

Background: Cutaneous metastases in the facial region occur in less than 0.5% of patients with metastatic cancer.

Case presentation: A 52-year-old woman who admitted with a lung and a skull skin nodule is presented. She had a known diagnosis of uterine leiomyosarcoma following an extended total hysterectomy two years ago. Excision biopsy of both nodules revealed metastatic disease.

Conclusion: The appearance of a cutaneous nodule in a patient with a history of uterine leiomyosarcoma might indicate a metastatic tumor lesion. Biopsy and immunohistochemistry are essential for correct diagnosis.

Show MeSH
Related in: MedlinePlus