Limits...
Ocular toxicity by latex of Calotropis procera (Sodom apple).

Basak SK, Bhaumik A, Mohanta A, Singhal P - Indian J Ophthalmol (2009 May-Jun)

Bottom Line: Three (10%) eyes had an epithelial defect, nine (31%) had iridocyclitis, and seven (24%) had associated secondary glaucoma.After three months, 17 (74%) out of 23 eyes showed a significant low endothelial cell count compared to the normal fellow eye ( P 0.001).The long-term effect on corneal endothelium has to be studied further.

View Article: PubMed Central - PubMed

Affiliation: Disha Eye Hospitals and Research Centre, Barrackpore, West Bengal, Kolkata - 700 120, India. basak_sk@hotmail.com

ABSTRACT
We report the spectrum of ocular toxicity following accidental inoculation of latex of Calotropis procera (Sodom apple) in 29 eyes between January 2003 and December 2006. All patients presented with sudden painless dimness of vision with photophobia. Twenty-five (86%) patients had initial visual acuity of less than 20/60. All eyes had conjunctival congestion and mild to severe corneal edema with Descemet's folds. Three (10%) eyes had an epithelial defect, nine (31%) had iridocyclitis, and seven (24%) had associated secondary glaucoma. After treatment with topical corticosteroids, antiglaucoma agents, cycloplegics, hypertonic saline and tears supplements, 27 (93%) eyes recovered completely within 3-14 days. After three months, 17 (74%) out of 23 eyes showed a significant low endothelial cell count compared to the normal fellow eye ( P 0.001). The latex of Calotropis procera causes significant ocular morbidity which may be preventable by simple health education. The long-term effect on corneal endothelium has to be studied further.

Show MeSH

Related in: MedlinePlus

Corneal edema and severe Descemet's folds in a patient after 48 hours
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2683444&req=5

Figure 0003: Corneal edema and severe Descemet's folds in a patient after 48 hours

Mentions: There was a strong male preponderance (83%), with only five female patients. Sixteen (55%) patients were flower vendors by profession and 21 (72%) patients had presented within 24 h of the injury. Right eye was affected in 25 (86%) cases [Table 1]. All eyes showed mild conjunctival congestion and mild to moderate ciliary congestion. All eyes had mild to severe corneal edema with Descemet's folds [Fig. 2a,2b], nine (31%) had mild to moderate degree of iridocyclitis, and seven (24%) had secondary glaucoma. The range in intraocular pressure rise in these eyes as recorded by NCT was between 8.0–11.5 mm of Hg as compared to the fellow normal eye. In 27 (93%) eyes, the mean period of complete resolution was 6.69 ± 2.70 days (range: 3–14 days) and the treatment was discontinued one week after the recovery. One case with large abrasion required bandage contact lens and complete resolution occurred after four weeks. The post-treatment BCVA returned to 20/20 in 26 (90%) cases with normal appearance of the cornea in all cases. In 17 (74%) out of 23 eyes, specular microscopy revealed a mean low cell count of 18.63 ± 9.91% after a period of three to six months in comparison to the normal fellow eye (P < 0.001) [Fig. 3a,3b].


Ocular toxicity by latex of Calotropis procera (Sodom apple).

Basak SK, Bhaumik A, Mohanta A, Singhal P - Indian J Ophthalmol (2009 May-Jun)

Corneal edema and severe Descemet's folds in a patient after 48 hours
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2683444&req=5

Figure 0003: Corneal edema and severe Descemet's folds in a patient after 48 hours
Mentions: There was a strong male preponderance (83%), with only five female patients. Sixteen (55%) patients were flower vendors by profession and 21 (72%) patients had presented within 24 h of the injury. Right eye was affected in 25 (86%) cases [Table 1]. All eyes showed mild conjunctival congestion and mild to moderate ciliary congestion. All eyes had mild to severe corneal edema with Descemet's folds [Fig. 2a,2b], nine (31%) had mild to moderate degree of iridocyclitis, and seven (24%) had secondary glaucoma. The range in intraocular pressure rise in these eyes as recorded by NCT was between 8.0–11.5 mm of Hg as compared to the fellow normal eye. In 27 (93%) eyes, the mean period of complete resolution was 6.69 ± 2.70 days (range: 3–14 days) and the treatment was discontinued one week after the recovery. One case with large abrasion required bandage contact lens and complete resolution occurred after four weeks. The post-treatment BCVA returned to 20/20 in 26 (90%) cases with normal appearance of the cornea in all cases. In 17 (74%) out of 23 eyes, specular microscopy revealed a mean low cell count of 18.63 ± 9.91% after a period of three to six months in comparison to the normal fellow eye (P < 0.001) [Fig. 3a,3b].

Bottom Line: Three (10%) eyes had an epithelial defect, nine (31%) had iridocyclitis, and seven (24%) had associated secondary glaucoma.After three months, 17 (74%) out of 23 eyes showed a significant low endothelial cell count compared to the normal fellow eye ( P 0.001).The long-term effect on corneal endothelium has to be studied further.

View Article: PubMed Central - PubMed

Affiliation: Disha Eye Hospitals and Research Centre, Barrackpore, West Bengal, Kolkata - 700 120, India. basak_sk@hotmail.com

ABSTRACT
We report the spectrum of ocular toxicity following accidental inoculation of latex of Calotropis procera (Sodom apple) in 29 eyes between January 2003 and December 2006. All patients presented with sudden painless dimness of vision with photophobia. Twenty-five (86%) patients had initial visual acuity of less than 20/60. All eyes had conjunctival congestion and mild to severe corneal edema with Descemet's folds. Three (10%) eyes had an epithelial defect, nine (31%) had iridocyclitis, and seven (24%) had associated secondary glaucoma. After treatment with topical corticosteroids, antiglaucoma agents, cycloplegics, hypertonic saline and tears supplements, 27 (93%) eyes recovered completely within 3-14 days. After three months, 17 (74%) out of 23 eyes showed a significant low endothelial cell count compared to the normal fellow eye ( P 0.001). The latex of Calotropis procera causes significant ocular morbidity which may be preventable by simple health education. The long-term effect on corneal endothelium has to be studied further.

Show MeSH
Related in: MedlinePlus