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Solitary fibrous tumor of the orbit presenting in pregnancy.

Das JK, Sharma AS, Deka ACh, Das D - Indian J Ophthalmol (2009 May-Jun)

Bottom Line: A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months.She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month.Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.

View Article: PubMed Central - PubMed

Affiliation: Sri Sankaradeva Nethralaya, Beltola, Guwahati, Assam - 781 028, India. jk2269929@yahoo.co.in

ABSTRACT
A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months. She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month. Computer tomography (CT) scan revealed a well-defined mass lesion in the intraconal space of the right orbit which was excised through a lateral orbitotomy approach. Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.

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(a) Lower magnification (×10) shows spindle-shaped cells with uniform nuclei (b) higher magnification (×40) shows spindle-shaped cells with uniform nuclei containing finely dispersed chromatin. Dense collagen bundles are woven between the cells (H and E stain)
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Figure 0003: (a) Lower magnification (×10) shows spindle-shaped cells with uniform nuclei (b) higher magnification (×40) shows spindle-shaped cells with uniform nuclei containing finely dispersed chromatin. Dense collagen bundles are woven between the cells (H and E stain)

Mentions: Hematoxylin and Eosin stain of multiple sections showed spindle cells arranged in hypercellular and hypocellular pattern with rich vascularity. Large numbers of capillaries containing erythrocytes were also noted in the periphery [Fig. 3a and 3b]. There was no evidence of mitotic figures or necrosis. With trichome staining, the tumor exhibited predominantly collagen production. Immunohistochemistry reactivity to CD34 confirmed the diagnosis of an orbital SFT. Subsequently, there was improvement in visual acuity from 20/120 to 20/20 in the right eye and normalization of IOP (14 mm Hg). No recurrence was noted over the two years of follow-up.


Solitary fibrous tumor of the orbit presenting in pregnancy.

Das JK, Sharma AS, Deka ACh, Das D - Indian J Ophthalmol (2009 May-Jun)

(a) Lower magnification (×10) shows spindle-shaped cells with uniform nuclei (b) higher magnification (×40) shows spindle-shaped cells with uniform nuclei containing finely dispersed chromatin. Dense collagen bundles are woven between the cells (H and E stain)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2683441&req=5

Figure 0003: (a) Lower magnification (×10) shows spindle-shaped cells with uniform nuclei (b) higher magnification (×40) shows spindle-shaped cells with uniform nuclei containing finely dispersed chromatin. Dense collagen bundles are woven between the cells (H and E stain)
Mentions: Hematoxylin and Eosin stain of multiple sections showed spindle cells arranged in hypercellular and hypocellular pattern with rich vascularity. Large numbers of capillaries containing erythrocytes were also noted in the periphery [Fig. 3a and 3b]. There was no evidence of mitotic figures or necrosis. With trichome staining, the tumor exhibited predominantly collagen production. Immunohistochemistry reactivity to CD34 confirmed the diagnosis of an orbital SFT. Subsequently, there was improvement in visual acuity from 20/120 to 20/20 in the right eye and normalization of IOP (14 mm Hg). No recurrence was noted over the two years of follow-up.

Bottom Line: A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months.She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month.Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.

View Article: PubMed Central - PubMed

Affiliation: Sri Sankaradeva Nethralaya, Beltola, Guwahati, Assam - 781 028, India. jk2269929@yahoo.co.in

ABSTRACT
A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months. She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month. Computer tomography (CT) scan revealed a well-defined mass lesion in the intraconal space of the right orbit which was excised through a lateral orbitotomy approach. Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.

Show MeSH
Related in: MedlinePlus